{"id":"https://openalex.org/W2031184536","doi":"https://doi.org/10.1002/jez.1402620405","title":"Modulation of meiotic arrest in mouse oocytes by guanyl nucleotides and modifiers of G\u2010proteins","display_name":"Modulation of meiotic arrest in mouse oocytes by guanyl nucleotides and modifiers of G\u2010proteins","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W2031184536","doi":"https://doi.org/10.1002/jez.1402620405","mag":"2031184536","pmid":"https://pubmed.ncbi.nlm.nih.gov/1320658"},"language":"en","primary_location":{"id":"doi:10.1002/jez.1402620405","doi":"https://doi.org/10.1002/jez.1402620405","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jez.1402620405","pdf_url":null,"source":{"id":"https://openalex.org/S4210222064","display_name":"Journal of Experimental Zoology","issn_l":"0022-104X","issn":["0022-104X","1097-010X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen M. Downs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen M. Downs","raw_affiliation_strings":["Biology Department, Marquette University, Milwaukee, Wisconsin 53233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Marquette University, Milwaukee, Wisconsin 53233","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017160524","display_name":"Roberto Buccione","orcid":"https://orcid.org/0000-0001-9210-5261","observed_orcids":["https://orcid.org/0000-0001-9210-5261"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Buccione","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110191925","display_name":"John J. Eppig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Eppig","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5476,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.54925094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"262","issue":"4","first_page":"391","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meiotic-arrest","display_name":"meiotic arrest","score":0.953000009059906},{"id":"https://openalex.org/keywords/meiotic-maturation","display_name":"meiotic maturation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.8360000252723694},{"id":"https://openalex.org/keywords/guanyl-nucleotides","display_name":"guanyl nucleotides","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gtpgammas","display_name":"GTP gamma S","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":1.0},{"id":"https://openalex.org/keywords/aluminum-fluoride","display_name":"aluminum fluoride","score":0.9869999885559082},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8040000200271606},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.906000018119812},{"id":"https://openalex.org/keywords/germinal-vesicle-breakdown","display_name":"germinal vesicle breakdown","score":0.9190000295639038},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cumulus-cells","display_name":"cumulus cells","score":0.7070000171661377},{"id":"https://openalex.org/keywords/oocytes","display_name":"oocytes","score":0.675000011920929},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.7548587322235107},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.7234256863594055},{"id":"https://openalex.org/C2994119143","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Germinal vesicle","level":4,"score":0.7057612538337708},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.6344720721244812},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5859144330024719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44197264313697815},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.43114209175109863},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.4277550280094147},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3740886151790619},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2962902784347534},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26863086223602295},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20513319969177246},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.12680068612098694},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005459","descriptor_name":"Fluorides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006150","descriptor_name":"Guanine Nucleotides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007042","descriptor_name":"Hypoxanthines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009866","descriptor_name":"Oogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010566","descriptor_name":"Virulence Factors, Bordetella","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015044","descriptor_name":"Zona Pellucida","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017607","descriptor_name":"Aluminum Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037361","descriptor_name":"Adenylate Cyclase Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jez.1402620405","doi":"https://doi.org/10.1002/jez.1402620405","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jez.1402620405","pdf_url":null,"source":{"id":"https://openalex.org/S4210222064","display_name":"Journal of Experimental Zoology","issn_l":"0022-104X","issn":["0022-104X","1097-010X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology","raw_type":"journal-article"},{"id":"pmid:1320658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1320658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental zoology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb1990_1999-1261","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb1990_1999/262","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 1990 - 1999","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6920419832","display_name":"PURINES AND THE MAINTENANCE OF MEIOTIC ARREST","funder_award_id":"R01HD025291","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7184565415","display_name":"REGULATION OF MAMMALIAN OOCYTE DEVELOPMENT","funder_award_id":"R01HD020575","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W142558481","https://openalex.org/W225588386","https://openalex.org/W586595461","https://openalex.org/W1498034410","https://openalex.org/W1498793897","https://openalex.org/W1499411585","https://openalex.org/W1516614444","https://openalex.org/W1529794526","https://openalex.org/W1532747508","https://openalex.org/W1537687810","https://openalex.org/W1556366583","https://openalex.org/W1567061008","https://openalex.org/W1569033208","https://openalex.org/W1570939625","https://openalex.org/W1596142603","https://openalex.org/W1598028013","https://openalex.org/W1900946340","https://openalex.org/W1966734405","https://openalex.org/W1968658549","https://openalex.org/W1971087119","https://openalex.org/W1973011556","https://openalex.org/W1974265269","https://openalex.org/W1975417310","https://openalex.org/W1975998142","https://openalex.org/W1977764079","https://openalex.org/W1980920465","https://openalex.org/W1988260141","https://openalex.org/W1990340850","https://openalex.org/W1992529920","https://openalex.org/W1993007390","https://openalex.org/W2003914219","https://openalex.org/W2007904803","https://openalex.org/W2010348828","https://openalex.org/W2014385979","https://openalex.org/W2014825777","https://openalex.org/W2014987538","https://openalex.org/W2015332201","https://openalex.org/W2021148581","https://openalex.org/W2022750564","https://openalex.org/W2024012460","https://openalex.org/W2029266821","https://openalex.org/W2029328131","https://openalex.org/W2030323914","https://openalex.org/W2031142805","https://openalex.org/W2031750572","https://openalex.org/W2034050442","https://openalex.org/W2046298808","https://openalex.org/W2046781755","https://openalex.org/W2048784760","https://openalex.org/W2053299519","https://openalex.org/W2058268581","https://openalex.org/W2058491704","https://openalex.org/W2061839799","https://openalex.org/W2062361602","https://openalex.org/W2062707142","https://openalex.org/W2063738348","https://openalex.org/W2072074796","https://openalex.org/W2080413833","https://openalex.org/W2080875376","https://openalex.org/W2093188668","https://openalex.org/W2095522722","https://openalex.org/W2110993745","https://openalex.org/W2119361029","https://openalex.org/W2120165254","https://openalex.org/W2133125965","https://openalex.org/W2150083639","https://openalex.org/W2170530908","https://openalex.org/W2176789797","https://openalex.org/W2190059169","https://openalex.org/W2196004373","https://openalex.org/W2410961661","https://openalex.org/W2438123340","https://openalex.org/W2474028405"],"related_works":["https://openalex.org/W1587094186","https://openalex.org/W2128288344","https://openalex.org/W7099837028","https://openalex.org/W7095976832","https://openalex.org/W2039974488","https://openalex.org/W2088078532","https://openalex.org/W2051053581","https://openalex.org/W1982189746","https://openalex.org/W2013229182","https://openalex.org/W1983505823"],"abstract_inverted_index":{"Guanyl":[0],"nucleotide":[1],"binding-proteins,":[2],"or":[3,34,137,149,225,241],"G-proteins,":[4,107],"are":[5,9],"ubiquitous":[6],"molecules":[7],"that":[8,214],"involved":[10,282],"in":[11,24,29,50,64,67,132,158,170,176,196,209,219,234,270],"cellular":[12],"signal":[13],"transduction":[14],"mechanisms.":[15],"Because":[16],"a":[17,68,316],"role":[18],"has":[19],"been":[20],"established":[21],"for":[22,87,110],"cAMP":[23,147,233],"meiosis":[25],"and":[26,70,94,121,181,212,250,268,278,286,304],"G-proteins":[27,49,269,277],"participate":[28],"cAMP-generating":[30],"systems":[31],"by":[32,295,314],"stimulating":[33],"inhibiting":[35],"adenylate":[36],"cyclase,":[37],"the":[38,45,51,76,203,230,253,263,271,284,299],"present":[39],"study":[40],"was":[41,85,143,168,187,192],"conducted":[42],"to":[43,104,113,312],"examine":[44],"possible":[46],"involvement":[47,264],"of":[48,53,206,215,232,256,265,273,298,302,307],"resumption":[52],"meiotic":[54,65,115,141,185],"maturation.":[55],"Cumulus":[56],"cell-free":[57],"mouse":[58],"oocytes":[59,136,139,161,180,183,211],"(denuded":[60],"oocytes)":[61],"were":[62,98,108,244],"maintained":[63,144,188],"arrest":[66,142,186],"transient":[69],"dose-dependent":[71],"manner":[72],"when":[73,140,184],"microinjected":[74],"with":[75,106,145,189],"nonhydrolyzable":[77],"GTP":[78,80,88],"analog,":[79],"gamma":[81,89,96],"S.":[82],"This":[83],"effect":[84,129],"specific":[86],"S,":[90],"because":[91],"GppNHp,":[92],"GTP,":[93],"ATP":[95],"S":[97],"without":[99,245],"effect.":[100,246],"Three":[101],"compounds,":[102],"known":[103],"interact":[105],"tested":[109],"their":[111],"ability":[112],"modulate":[114],"maturation:":[116],"pertussis":[117,239],"toxin,":[118,120],"cholera":[119,207,248],"aluminum":[122],"fluoride":[123],"(AlF4-).":[124],"Pertussis":[125],"toxin":[126,152,208,224,240,249,291],"had":[127],"little":[128],"on":[130,258],"maturation":[131],"either":[133],"cumulus":[134,159,178,220,287],"cell-enclosed":[135,160,179,221],"denuded":[138,171,182,210],"dibutyryl":[146],"(dbcAMP)":[148],"hypoxanthine.":[150],"Cholera":[151,223,290],"stimulated":[153,174,229],"germinal":[154],"vesicle":[155],"breakdown":[156],"(GVB)":[157],"during":[162],"long-term":[163],"culture,":[164],"but":[165,191],"its":[166],"action":[167,205,255],"inhibitory":[169,204],"oocytes.":[172,198,222],"AlF4-":[173,201,242,251,310],"GVB":[175],"both":[177],"hypoxanthine":[190],"much":[193],"less":[194],"effective":[195],"dbcAMP-arrested":[197],"In":[199],"addition,":[200],"abrogated":[202],"also":[213],"follicle-stimulating":[216],"hormone":[217],"(FSH)":[218],"FSH":[226,257],"alone":[227,243],"each":[228],"synthesis":[231],"oocyte-cumulus":[235],"cell":[236,288],"complexes,":[237],"whereas":[238,309],"Both":[247],"augmented":[252],"stimulatory":[254],"cAMP.":[259],"These":[260],"data":[261],"suggest":[262],"guanyl":[266],"nucleotides":[267],"regulation":[272],"GVB,":[274],"although":[275],"different":[276],"mediators":[279],"may":[280],"be":[281],"at":[283],"oocyte":[285],"levels.":[289],"most":[292],"likely":[293],"acts":[294],"ADP":[296],"ribosylation":[297],"alpha":[300],"subunit":[301],"Gs":[303],"increased":[305],"generation":[306],"cAMP,":[308],"appears":[311],"act":[313],"antagonizing":[315],"cAMP-dependent":[317],"step.":[318]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}