{"id":"https://openalex.org/W2031179986","doi":"https://doi.org/10.1182/blood-2007-08-109306","title":"Effect of transfusional iron intake on response to chelation therapy in \u03b2-thalassemia major","display_name":"Effect of transfusional iron intake on response to chelation therapy in \u03b2-thalassemia major","publication_year":2007,"publication_date":"2007-10-19","ids":{"openalex":"https://openalex.org/W2031179986","doi":"https://doi.org/10.1182/blood-2007-08-109306","mag":"2031179986","pmid":"https://pubmed.ncbi.nlm.nih.gov/17951527"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2007-08-109306","doi":"https://doi.org/10.1182/blood-2007-08-109306","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-08-109306","pdf_url":"https://ashpublications.org/blood/article-pdf/111/2/583/1220496/zh800208000583.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/111/2/583/1220496/zh800208000583.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101889067","display_name":"Alan R. Cohen","orcid":"https://orcid.org/0000-0002-9506-6541","observed_orcids":["https://orcid.org/0000-0002-9506-6541"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R. Cohen","raw_affiliation_strings":["Children's Hospital of Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia, PA;","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014324908","display_name":"Ekkehard Glimm","orcid":"https://orcid.org/0000-0003-3624-961X","observed_orcids":["https://orcid.org/0000-0003-3624-961X"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ekkehard Glimm","raw_affiliation_strings":["Novartis Pharmaceuticals, Basel, Switzerland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, Basel, Switzerland; and","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049244658","display_name":"John B. Porter","orcid":"https://orcid.org/0000-0003-3000-9359","observed_orcids":["https://orcid.org/0000-0003-3000-9359"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John B. Porter","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":8.9922,"has_fulltext":true,"cited_by_count":180,"citation_normalized_percentile":{"value":0.98398675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"111","issue":"2","first_page":"583","last_page":"587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-thalassemia-major","display_name":"beta-thalassemia major","score":0.8830000162124634},{"id":"https://openalex.org/keywords/chelation-therapy","display_name":"chelation therapy","score":0.847000002861023},{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":0.9520000219345093},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9440000057220459},{"id":"https://openalex.org/keywords/liver-iron-concentration","display_name":"liver iron concentration","score":0.984000027179718},{"id":"https://openalex.org/keywords/iron-balance","display_name":"iron balance","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6499999761581421},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/red-blood-cell-transfusion","display_name":"red blood cell transfusion","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.9873801469802856},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.8642081022262573},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.7859504222869873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7085313200950623},{"id":"https://openalex.org/C2777218474","wikidata":"https://www.wikidata.org/wiki/Q1069061","display_name":"Chelation therapy","level":3,"score":0.6638013124465942},{"id":"https://openalex.org/C2777940137","wikidata":"https://www.wikidata.org/wiki/Q3616632","display_name":"Beta thalassemia","level":3,"score":0.4917319118976593},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48061150312423706},{"id":"https://openalex.org/C2776517179","wikidata":"https://www.wikidata.org/wiki/Q749664","display_name":"Deferiprone","level":3,"score":0.46120068430900574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43629810214042664}],"mesh":[{"descriptor_ui":"D000077588","descriptor_name":"Deferasirox","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003676","descriptor_name":"Deferoxamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013156","descriptor_name":"Splenectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017707","descriptor_name":"Erythrocyte Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2007-08-109306","doi":"https://doi.org/10.1182/blood-2007-08-109306","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-08-109306","pdf_url":"https://ashpublications.org/blood/article-pdf/111/2/583/1220496/zh800208000583.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:17951527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17951527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:8243","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/8243/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BLOOD , 111 (2) 583 - 587. (2008)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2007-08-109306","doi":"https://doi.org/10.1182/blood-2007-08-109306","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-08-109306","pdf_url":"https://ashpublications.org/blood/article-pdf/111/2/583/1220496/zh800208000583.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031179986.pdf","grobid_xml":"https://content.openalex.org/works/W2031179986.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1003294699","https://openalex.org/W1559980214","https://openalex.org/W1576345300","https://openalex.org/W1988974302","https://openalex.org/W1995812599","https://openalex.org/W2047446466","https://openalex.org/W2055355532","https://openalex.org/W2069553612","https://openalex.org/W2069830637","https://openalex.org/W2077187279","https://openalex.org/W2092519006","https://openalex.org/W2119692077","https://openalex.org/W2124219007","https://openalex.org/W2318456157","https://openalex.org/W2338855129","https://openalex.org/W2499717514","https://openalex.org/W2552369836","https://openalex.org/W4285719527","https://openalex.org/W6662387504"],"related_works":["https://openalex.org/W7074003356","https://openalex.org/W2586853524","https://openalex.org/W2559540108","https://openalex.org/W2438856471","https://openalex.org/W2741258812","https://openalex.org/W2336783598","https://openalex.org/W3185021967","https://openalex.org/W2496291995","https://openalex.org/W2560440533","https://openalex.org/W2510866156"],"abstract_inverted_index":{"The":[0],"success":[1],"of":[2,24,36,40,57,74,89,103,119,137,142,148,187,199],"chelation":[3],"therapy":[4,93],"in":[5,9,47,52,69,84,115,140,162,180],"controlling":[6],"iron":[7,26,49,58,65,97,111,127,138,150,157,163,171,189],"overload":[8],"patients":[10,70,120,143,153,166],"with":[11,95,121,144,167],"thalassemia":[12,181],"major":[13,182],"is":[14,205],"highly":[15],"variable":[16],"and":[17,45,76,117,124,159,184],"may":[18],"partly":[19],"depend":[20],"on":[21,60,176],"the":[22,31,55,77,122,185,196],"rate":[23,147,186],"transfusional":[25,96,126,149,156,188],"loading.":[27],"Using":[28],"data":[29],"from":[30],"1-year":[32],"phase":[33],"III":[34],"study":[35,204],"deferasirox,":[37],"including":[38],"volumes":[39],"transfused":[41],"red":[42],"blood":[43],"cells":[44],"changes":[46],"liver":[48],"concentration":[50],"(LIC)":[51],"541":[53],"patients,":[54,183],"effect":[56],"loading":[59,190],"achieving":[61],"neutral":[62,108],"or":[63,91,109],"negative":[64,110],"balance":[66,112],"was":[67,113],"assessed":[68],"receiving":[71],"different":[72],"doses":[73],"deferasirox":[75,90,101],"comparator":[78],"deferoxamine.":[79],"After":[80],"dose":[81,102,198],"adjustment,":[82],"reductions":[83,161],"LIC":[85],"after":[86],"1":[87],"year":[88],"deferoxamine":[92],"correlated":[94],"intake.":[98,151],"At":[99],"a":[100,145],"20":[104],"mg/kg":[105,131],"per":[106,132],"day,":[107],"achieved":[114],"46%":[116],"75%":[118],"highest":[123],"lowest":[125],"intake,":[128],"respectively;":[129],"30":[130],"day":[133],"produced":[134],"successful":[135],"control":[136],"stores":[139,164],"96%":[141],"low":[146],"Splenectomized":[152],"had":[154],"lower":[155],"intake":[158,172],"greater":[160],"than":[165],"intact":[168],"spleens.":[169],"Transfusional":[170],"should":[173,191],"be":[174,192],"monitored":[175],"an":[177,200],"ongoing":[178],"basis":[179],"considered":[193],"when":[194],"choosing":[195],"appropriate":[197],"iron-chelating":[201],"agent.":[202],"This":[203],"registered":[206],"at":[207],"http://clinicaltrials.gov":[208],"as":[209],"NCT00061750.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
