{"id":"https://openalex.org/W2031166189","doi":"https://doi.org/10.1097/00005768-200305001-01030","title":"ACE GENOTYPE ALTERS THE BLOOD PRESSURE RESPONSE TO ENDURANCE EXERCISE AMONG MEN WITH HYPERTENSION","display_name":"ACE GENOTYPE ALTERS THE BLOOD PRESSURE RESPONSE TO ENDURANCE EXERCISE AMONG MEN WITH HYPERTENSION","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W2031166189","doi":"https://doi.org/10.1097/00005768-200305001-01030","mag":"2031166189"},"language":"en","primary_location":{"id":"doi:10.1097/00005768-200305001-01030","doi":"https://doi.org/10.1097/00005768-200305001-01030","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-200305001-01030","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine & Science in Sports & Exercise","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111769257","display_name":"Bruce E. Blanchard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B E. Blanchard","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001250550","display_name":"Gregory J. Tsongalis","orcid":"https://orcid.org/0000-0002-0792-3196","observed_orcids":["https://orcid.org/0000-0002-0792-3196"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G J. Tsongalis","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055279706","display_name":"Margaux A. Guidry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A. Guidry","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A J. Kerr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A J. Kerr","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037048305","display_name":"Lisa A. LaBelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L A. LaBelle","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Poulin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Poulin","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010473740","display_name":"A L. Wark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Wark","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051431608","display_name":"Carl M. Maresh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M. Maresh","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P D. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P D. Thompson","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010056359","display_name":"Linda Shannon Pescatello","orcid":"https://orcid.org/0000-0002-5841-798X","observed_orcids":["https://orcid.org/0000-0002-5841-798X"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L S. Pescatello","raw_affiliation_strings":["University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT and Hartford Hospital, Hartford, CT","institution_ids":["https://openalex.org/I1302163369","https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"Supplement 1","first_page":"S185","last_page":"S185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ace-insertion-deletion-polymorphism","display_name":"ACE I/D polymorphism","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8840000033378601},{"id":"https://openalex.org/keywords/endurance-exercise","display_name":"endurance exercise","score":0.8519999980926514},{"id":"https://openalex.org/keywords/blood-pressure-response","display_name":"blood pressure response","score":0.8370000123977661},{"id":"https://openalex.org/keywords/post-exercise-hypotension","display_name":"post-exercise hypotension","score":0.703000009059906},{"id":"https://openalex.org/keywords/aerobic-exercise-intensity","display_name":"aerobic exercise intensity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.4740000069141388},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure-monitoring","display_name":"ambulatory blood pressure monitoring","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cycle-exercise","display_name":"cycling exercise","score":0.48100000619888306},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.7599999904632568},{"id":"https://openalex.org/keywords/diastolic-blood-pressure","display_name":"diastolic blood pressure","score":1.0},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.814932644367218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8112993240356445},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7290603518486023},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.7226543426513672},{"id":"https://openalex.org/C196310339","wikidata":"https://www.wikidata.org/wiki/Q60354","display_name":"VO2 max","level":4,"score":0.5887289047241211},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5745663642883301},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.49964404106140137},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.48170071840286255},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.47858381271362305},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.4575267732143402},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4255509078502655},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3226543664932251}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00005768-200305001-01030","doi":"https://doi.org/10.1097/00005768-200305001-01030","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-200305001-01030","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine & Science in Sports & Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3037449018","https://openalex.org/W1829279805","https://openalex.org/W1984783549","https://openalex.org/W173422366","https://openalex.org/W2275037344","https://openalex.org/W2095997376","https://openalex.org/W1555092079","https://openalex.org/W2613941821","https://openalex.org/W4385078060","https://openalex.org/W2516899024"],"abstract_inverted_index":{"PURPOSE":[0],"ACE":[1,30,116,120,149,190,203,210,228],"genotype":[2,31],"modifies":[3],"the":[4,25,55,93,101,214,235,265],"blood":[5,126,167],"pressure":[6,127,168],"(BP)":[7],"response":[8,28,216],"to":[9,217,234,257,264],"endurance":[10,245],"exercise":[11,79,201,220,253],"in":[12,32,189,202,221],"people":[13],"with":[14,34,42,223],"normal":[15],"BP.":[16],"It":[17],"is":[18,254],"not":[19],"clear":[20],"if":[21,106],"associations":[22],"exist":[23],"between":[24,112,159,198],"postexercise":[26],"BP":[27,48,98,107,215,225,237,267],"and":[29,111,115,139,152,161,180,193,200,206],"men":[33,40,66,222,258],"hypertension.":[35],"METHODS":[36],"Volunteers":[37],"were":[38,52],"24":[39,45],"(46.0\u00b11.9y)":[41],"a":[43,69],"mean":[44,123,155,164],"hr":[46,188],"ambulatory":[47,97],"of":[49,73,83,240],"138.7\u00b12.0/83.4\u00b11.5mmHg.":[50],"Subjects":[51,91],"genotyped":[53],"for":[54,145,186],"angiotensin":[56],"converting":[57],"enzyme":[58],"(ACE)":[59],"insertion(I)/deletion(D)":[60],"polymorphism.":[61],"On":[62],"three":[63],"different":[64],"days":[65],"randomly":[67],"completed":[68],"40":[70],"min":[71],"session":[72],"either":[74,81],"rest":[75],"(control)":[76],"or":[77,88],"cycle":[78],"at":[80],"40%":[82,132,173],"maximal":[84],"oxygen":[85],"consumption":[86],"(VO2max)":[87],"60%":[89,136,177],"VO2max.":[90],"left":[92],"laboratory":[94],"wearing":[95],"an":[96,271],"monitor":[99],"until":[100],"next":[102],"morning.":[103],"RMANOVA":[104],"determined":[105],"differed":[108],"over":[109],"time":[110],"experimental":[113],"conditions":[114],"polymorphisms.":[117],"RESULTS":[118],"In":[119,148],"DD":[121,191,229],"homozygotes,":[122,192],"adjusted":[124,165],"systolic":[125],"(SBP)":[128],"was":[129,157,170,196],"lower":[130,171],"after":[131,172],"VO2max":[133,137,174,178],"(128.3\u00b12.9mmHg)":[134],"than":[135,176],"(132.3\u00b12.7mmHg)":[138],"control":[140,160,181,199],"(133.2\u00b12.9mmHg)":[141],"(p":[142,183],"=":[143,184],"0.030)":[144],"12":[146],"hr.":[147],"II":[150,204],"homozygotes":[151,205,230],"ID":[153,207,211],"heterozygotes,":[154],"SBP":[156],"similar":[158,197],"exercise.":[162,246],"Similarly,":[163],"diastolic":[166],"(DBP)":[169],"(80.0\u00b12.6mmHg)":[175],"(82.9\u00b12.4mmHg)":[179],"(83.0\u00b12.3mmHg)":[182],"0.048)":[185],"15":[187],"average":[194],"DBP":[195],"heterozygotes.":[208],"CONCLUSION":[209],"variants":[212],"altered":[213],"acute":[218],"dynamic":[219],"high":[224],"such":[226],"that":[227],"responded":[231],"most":[232,255],"readily":[233],"immediate":[236],"lowering":[238],"capacities":[239],"moderate":[241,250],"intensity":[242,251],"(40%":[243],"VO2max)":[244],"Our":[247],"results":[248],"suggest":[249],"aerobic":[252],"beneficial":[256],"who":[259],"may":[260],"be":[261],"genetically":[262],"predisposed":[263],"highest":[266],"levels.":[268],"Supported":[269],"by":[270],"American":[272],"Heart":[273],"Association":[274],"Grant-in-Aid.":[275]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}