{"id":"https://openalex.org/W2031023045","doi":"https://doi.org/10.1002/prp2.45","title":"Dexmedetomidine preconditioning ameliorates kidney ischemia\u2010reperfusion injury","display_name":"Dexmedetomidine preconditioning ameliorates kidney ischemia\u2010reperfusion injury","publication_year":2014,"publication_date":"2014-04-22","ids":{"openalex":"https://openalex.org/W2031023045","doi":"https://doi.org/10.1002/prp2.45","mag":"2031023045","pmid":"https://pubmed.ncbi.nlm.nih.gov/25505591","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4186414"},"language":"en","primary_location":{"id":"doi:10.1002/prp2.45","doi":"https://doi.org/10.1002/prp2.45","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prp2.45","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prp2.45","source":{"id":"https://openalex.org/S2764487716","display_name":"Pharmacology Research & Perspectives","issn_l":"2052-1707","issn":["2052-1707"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology Research & Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prp2.45","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076300455","display_name":"Juha Lempi\u00e4inen","orcid":"https://orcid.org/0000-0002-5914-6202","observed_orcids":["https://orcid.org/0000-0002-5914-6202"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Juha Lempi\u00e4inen","raw_affiliation_strings":["Institute of Biomedicine, Pharmacology University of Helsinki Helsinki Finland","#N# Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Pharmacology University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"#N# Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062365399","display_name":"Piet Finckenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Piet Finckenberg","raw_affiliation_strings":["Institute of Biomedicine, Pharmacology University of Helsinki Helsinki Finland","#N# Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Pharmacology University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"#N# Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079059235","display_name":"Elina E. Mervaala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Elina E. Mervaala","raw_affiliation_strings":["Institute of Biomedicine, Pharmacology University of Helsinki Helsinki Finland","#N# Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Pharmacology University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"#N# Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091492708","display_name":"Markus Storvik","orcid":"https://orcid.org/0000-0003-4186-6313","observed_orcids":["https://orcid.org/0000-0003-4186-6313"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Markus Storvik","raw_affiliation_strings":["School of Pharmacy, University of Eastern Finland Kuopio Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Eastern Finland Kuopio Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032482206","display_name":"Juha Kaivola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Juha Kaivola","raw_affiliation_strings":["Orion Pharma Ltd. Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orion Pharma Ltd. Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108506711","display_name":"Ken A. Lindstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ken Lindstedt","raw_affiliation_strings":["Orion Pharma Ltd. Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orion Pharma Ltd. Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023582033","display_name":"Jouko M. Levijoki","orcid":"https://orcid.org/0000-0002-3504-122X","observed_orcids":["https://orcid.org/0000-0002-3504-122X"]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jouko Levijoki","raw_affiliation_strings":["Orion Pharma Ltd. Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orion Pharma Ltd. Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110887705","display_name":"Eero M. A. Mervaala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Eero M. Mervaala","raw_affiliation_strings":["Institute of Biomedicine, Pharmacology University of Helsinki Helsinki Finland","#N# Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Pharmacology University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"#N# Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110887705"],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":{"value":4160,"currency":"USD","value_usd":4160},"fwci":5.1775,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.95458904,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2","issue":"3","first_page":"e00045","last_page":"e00045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":1.0},{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.9900000095367432},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.8119999766349792},{"id":"https://openalex.org/keywords/preconditioning","display_name":"preconditioning","score":0.6850000023841858},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.7950000166893005},{"id":"https://openalex.org/keywords/acute-tubular-necrosis","display_name":"acute tubular necrosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9850000143051147},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.984000027179718},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.8309999704360962},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.5370000004768372},{"id":"https://openalex.org/keywords/renal-transcriptome","display_name":"renal transcriptome","score":0.6330000162124634},{"id":"https://openalex.org/keywords/ischemic-preconditioning","display_name":"ischemic preconditioning","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6125428080558777},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5565516352653503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5543915033340454},{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.5157442688941956},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5052264332771301},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.4855356216430664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4757532775402069},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46585971117019653},{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.4410150945186615},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4250749349594116},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/prp2.45","doi":"https://doi.org/10.1002/prp2.45","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prp2.45","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prp2.45","source":{"id":"https://openalex.org/S2764487716","display_name":"Pharmacology Research & Perspectives","issn_l":"2052-1707","issn":["2052-1707"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology Research & Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4186414","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4186414","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacol Res Perspect","raw_type":"Text"},{"id":"pmid:25505591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25505591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology research & perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:helda.helsinki.fi:10138/232487","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/232487","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/prp2.45","doi":"https://doi.org/10.1002/prp2.45","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prp2.45","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prp2.45","source":{"id":"https://openalex.org/S2764487716","display_name":"Pharmacology Research & Perspectives","issn_l":"2052-1707","issn":["2052-1707"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology Research & Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031023045.pdf","grobid_xml":"https://content.openalex.org/works/W2031023045.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1535531032","https://openalex.org/W1827587211","https://openalex.org/W1953709639","https://openalex.org/W1967791587","https://openalex.org/W1969323641","https://openalex.org/W1970455187","https://openalex.org/W1973111443","https://openalex.org/W1987535889","https://openalex.org/W1995323288","https://openalex.org/W1999322360","https://openalex.org/W1999485470","https://openalex.org/W2004094738","https://openalex.org/W2020895828","https://openalex.org/W2040580133","https://openalex.org/W2042617602","https://openalex.org/W2048287855","https://openalex.org/W2050916570","https://openalex.org/W2059480660","https://openalex.org/W2062077365","https://openalex.org/W2062483942","https://openalex.org/W2065436433","https://openalex.org/W2066994714","https://openalex.org/W2069728361","https://openalex.org/W2071612590","https://openalex.org/W2073625832","https://openalex.org/W2073711902","https://openalex.org/W2075092111","https://openalex.org/W2078111650","https://openalex.org/W2084891501","https://openalex.org/W2086708696","https://openalex.org/W2091241231","https://openalex.org/W2092936320","https://openalex.org/W2093366031","https://openalex.org/W2109718015","https://openalex.org/W2110678628","https://openalex.org/W2119085035","https://openalex.org/W2122683221","https://openalex.org/W2123024844","https://openalex.org/W2127492230","https://openalex.org/W2127916470","https://openalex.org/W2129962143","https://openalex.org/W2154996185","https://openalex.org/W2164965999","https://openalex.org/W2169341893","https://openalex.org/W2319529606","https://openalex.org/W4255290985","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7095956502","https://openalex.org/W3017149256","https://openalex.org/W2354581765","https://openalex.org/W2590944202","https://openalex.org/W3014812367","https://openalex.org/W2387135631","https://openalex.org/W2101674165","https://openalex.org/W2063735457","https://openalex.org/W4389245187","https://openalex.org/W2255714398"],"abstract_inverted_index":{"Kidney":[0,111],"ischemia-reperfusion":[1],"(I/R)":[2],"injury":[3,241],"is":[4],"a":[5],"common":[6],"cause":[7],"of":[8,70,86,182,203,219],"acute":[9,103,158],"kidney":[10,24,144,239],"injury.":[11,26],"We":[12],"tested":[13],"whether":[14],"dexmedetomidine":[15],"(Dex),":[16],"an":[17],"alpha2":[18],"adrenoceptor":[19],"(\u03b12-AR)":[20],"agonist,":[21],"protects":[22],"against":[23],"I/R":[25,38,49,62,154,240],"Sprague-Dawley":[27],"rats":[28],"were":[29,92,97,141],"divided":[30],"into":[31],"four":[32],"groups:":[33],"(1)":[34],"Sham-operated":[35],"group;":[36],"(2)":[37],"group":[39,50,63],"(40":[40],"min":[41,57],"ischemia":[42],"followed":[43],"by":[44],"24":[45],"h":[46],"reperfusion);":[47],"(3)":[48],"+":[51,64],"Dex":[52,65,71,148,172,191,236],"(1":[53],"\u03bcg/kg":[54,77],"i.v.":[55,78],"60":[56],"before":[58],"the":[59,84],"surgery),":[60],"(4)":[61],"(10":[66],"\u03bcg/kg).":[67],"The":[68],"effects":[69,85,96],"postconditiong":[72],"(Dex":[73],"1":[74],"or":[75],"10":[76],"after":[79],"reperfusion)":[80],"as":[81,83],"well":[82],"peripheral":[87],"\u03b12-AR":[88],"agonism":[89],"with":[90,107,168],"fadolmidine":[91,169],"also":[93,253],"examined.":[94],"Hemodynamic":[95],"monitored,":[98],"renal":[99,156,186],"function":[100],"measured,":[101,142],"and":[102,134,143,161,184,188,194,205,213,221,242,251],"tubular":[104,159],"damage":[105],"along":[106],"monocyte/macrophage":[108],"infiltration":[109],"scored.":[110],"protein":[112,124],"kinase":[113,125,132],"B,":[114],"toll":[115],"like":[116],"receptor":[117,231],"4,":[118],"light":[119],"chain":[120],"3B,":[121],"p38":[122,187],"mitogen-activated":[123],"(p38":[126],"MAPK),":[127],"sirtuin":[128],"1,":[129],"adenosine":[130],"monophosphate":[131],"(AMPK),":[133],"endothelial":[135],"nitric":[136],"oxide":[137],"synthase":[138],"(eNOS)":[139],"expressions":[140],"transciptome":[145],"profiles":[146],"analyzed.":[147],"preconditioning,":[149],"but":[150],"not":[151],"postconditioning,":[152],"attenuated":[153],"injury-induced":[155],"dysfunction,":[157],"necrosis":[160],"inflammatory":[162,243],"response.":[163],"Neither":[164],"pre-":[165],"nor":[166],"postconditioning":[167],"protected":[170],"kidneys.":[171],"decreased":[173],"blood":[174],"pressure":[175],"more":[176],"than":[177],"fadolmidine,":[178],"ameliorated":[179],"I/R-induced":[180],"impairment":[181],"autophagy":[183],"increased":[185],"eNOS":[189],"expressions.":[190],"downregulated":[192],"245":[193],"upregulated":[195],"61":[196],"genes":[197],"representing":[198],"17":[199],"enriched":[200],"Kyoto":[201],"Encyclopedia":[202],"Genes":[204],"Genomes":[206],"(KEGG)":[207],"pathways,":[208,227],"in":[209,247],"particular,":[210],"integrin":[211],"pathway":[212,233],"CD44.":[214],"Ingenuity":[215],"analysis":[216],"revealed":[217],"inhibition":[218],"Rac":[220],"nuclear":[222],"factor":[223],"(erythroid-derived":[224],"2)-like":[225],"2":[226],"whereas":[228],"aryl":[229],"hydrocarbon":[230],"(AHR)":[232],"was":[234],"activated.":[235],"preconditioning":[237],"ameliorates":[238],"response,":[244],"at":[245],"least":[246],"part,":[248],"through":[249,254],"p38-CD44-pathway":[250],"possibly":[252],"ischemic":[255],"preconditioning.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}