{"id":"https://openalex.org/W2030959929","doi":"https://doi.org/10.1128/iai.70.7.3965-3968.2002","title":"Mycobacterium tuberculosisCDC1551 Is Resistant to Reactive Nitrogen and Oxygen Intermediates In Vitro","display_name":"Mycobacterium tuberculosisCDC1551 Is Resistant to Reactive Nitrogen and Oxygen Intermediates In Vitro","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2030959929","doi":"https://doi.org/10.1128/iai.70.7.3965-3968.2002","mag":"2030959929","pmid":"https://pubmed.ncbi.nlm.nih.gov/12065545","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/128088"},"language":"en","primary_location":{"id":"doi:10.1128/iai.70.7.3965-3968.2002","doi":"https://doi.org/10.1128/iai.70.7.3965-3968.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.70.7.3965-3968.2002","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/128088","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041955209","display_name":"Marcia A. Firmani","orcid":"https://orcid.org/0000-0002-0616-866X","observed_orcids":["https://orcid.org/0000-0002-0616-866X"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcia A. Firmani","raw_affiliation_strings":["School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720","School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023155188","display_name":"Lee W. Riley","orcid":"https://orcid.org/0000-0001-9916-3894","observed_orcids":["https://orcid.org/0000-0001-9916-3894"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lee W. Riley","raw_affiliation_strings":["School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023155188"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":0.8307,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.73741622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"70","issue":"7","first_page":"3965","last_page":"3968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7829999923706055},{"id":"https://openalex.org/keywords/reactive-nitrogen-intermediates","display_name":"reactive nitrogen intermediates","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-stress-tolerance","display_name":"oxidative stress resistance","score":0.796999990940094},{"id":"https://openalex.org/keywords/hydrogen-peroxide-tolerance","display_name":"hydrogen peroxide resistance","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tuberculosis-outbreak","display_name":"tuberculosis outbreak","score":0.7210000157356262},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.652999997138977},{"id":"https://openalex.org/keywords/strain-comparison","display_name":"strain comparison","score":0.6589999794960022},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis-h37rv","display_name":"Mycobacterium tuberculosis H37Rv","score":0.7900000214576721},{"id":"https://openalex.org/keywords/bcg","display_name":"BCG","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mycobacterium-bovis","display_name":"Mycobacterium bovis","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7594420313835144},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7482156157493591},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6918209195137024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6247754693031311},{"id":"https://openalex.org/C2778497218","wikidata":"https://www.wikidata.org/wiki/Q133447","display_name":"Mycobacterium bovis","level":4,"score":0.6205055117607117},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.5352571606636047},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5324830412864685},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.514768123626709},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21267467737197876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10933414101600647},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.04127448797225952}],"mesh":[{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007629","descriptor_name":"Kentucky","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012977","descriptor_name":"Sodium Nitrite","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013714","descriptor_name":"Tennessee","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026361","descriptor_name":"Reactive Nitrogen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/iai.70.7.3965-3968.2002","doi":"https://doi.org/10.1128/iai.70.7.3965-3968.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.70.7.3965-3968.2002","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:128088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/128088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:12065545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12065545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:128088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/128088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1645135143","display_name":null,"funder_award_id":"DA 05874","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4026822521","display_name":"NITRIC OXIDE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS","funder_award_id":"F31DA005874","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4615195231","display_name":"ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSIS","funder_award_id":"R01HL051967","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4815429654","display_name":null,"funder_award_id":"HL51967","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1914611833","https://openalex.org/W1945178855","https://openalex.org/W1967255828","https://openalex.org/W1977929630","https://openalex.org/W1985316233","https://openalex.org/W1991412746","https://openalex.org/W2019255399","https://openalex.org/W2035579424","https://openalex.org/W2040905406","https://openalex.org/W2042360733","https://openalex.org/W2048597976","https://openalex.org/W2057516079","https://openalex.org/W2075993349","https://openalex.org/W2081201008","https://openalex.org/W2089262366","https://openalex.org/W2093653384","https://openalex.org/W2100219870","https://openalex.org/W2109484445","https://openalex.org/W2109610001","https://openalex.org/W2114220827","https://openalex.org/W2117667204","https://openalex.org/W2120327701","https://openalex.org/W2123768471","https://openalex.org/W2130046741","https://openalex.org/W2131265202","https://openalex.org/W2131502319","https://openalex.org/W2134710797","https://openalex.org/W2135354451","https://openalex.org/W2138288701","https://openalex.org/W2143067750","https://openalex.org/W2148104823","https://openalex.org/W2161273761"],"related_works":["https://openalex.org/W1966942247","https://openalex.org/W1914611833","https://openalex.org/W7100495465","https://openalex.org/W7099796147","https://openalex.org/W2734828914","https://openalex.org/W2123768471","https://openalex.org/W1991412746","https://openalex.org/W1533137517","https://openalex.org/W1945178855","https://openalex.org/W2018752560"],"abstract_inverted_index":{"Resistance":[0],"to":[1,28,60,92],"reactive":[2,6],"oxygen":[3],"intermediates":[4,8],"and":[5,41,51,54,65],"nitrogen":[7],"in":[9,82],"vitro":[10,83],"of":[11,15,24,30,88,97],"a":[12,21,94],"clinical":[13,86],"isolate":[14],"Mycobacterium":[16],"tuberculosis":[17,25,32,90],"(CDC1551)":[18],"that":[19,29],"caused":[20],"large":[22,95],"outbreak":[23,96],"was":[26],"compared":[27],"M.":[31,47,89],"strains":[33,49,73,87],"CB3.3,":[34],"H37Rv,":[35],"H37Ra,":[36],"Erdman,":[37],"RJ2E,":[38],"C.C.":[39,42],"13,":[40],"22":[43],"as":[44,46,80],"well":[45],"bovis":[48],"Ravenel":[50],"BCG.":[52],"CDC1551":[53],"CB3.3":[55],"were":[56,70],"significantly":[57],"more":[58],"resistant":[59],"both":[61],"hydrogen":[62],"peroxide":[63],"(H(2)O(2))":[64],"acidified":[66],"sodium":[67],"nitrite":[68],"than":[69],"the":[71],"other":[72],"tested.":[74],"This":[75],"biological":[76],"phenotype":[77],"may":[78],"serve":[79],"an":[81],"marker":[84],"for":[85],"likely":[91],"cause":[93],"tuberculosis.":[98]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}