{"id":"https://openalex.org/W2030907941","doi":"https://doi.org/10.2147/ijn.s43168","title":"A nonviral pHEMA+chitosan nanosphere-mediated high-efficiency gene delivery system","display_name":"A nonviral pHEMA+chitosan nanosphere-mediated high-efficiency gene delivery system","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2030907941","doi":"https://doi.org/10.2147/ijn.s43168","mag":"2030907941","pmid":"https://pubmed.ncbi.nlm.nih.gov/23610520","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3629879"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s43168","doi":"https://doi.org/10.2147/ijn.s43168","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s43168","pdf_url":"https://www.dovepress.com/getfile.php?fileID=15747","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=15747","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055418907","display_name":"Shree Ram Singh","orcid":"https://orcid.org/0000-0002-3571-2222","observed_orcids":["https://orcid.org/0000-0002-3571-2222"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shree Singh","raw_affiliation_strings":["Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003509985","display_name":"Pooja Munnilal Tiwari","orcid":"https://orcid.org/0000-0001-8170-3602","observed_orcids":["https://orcid.org/0000-0001-8170-3602"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiwari","raw_affiliation_strings":["Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108085191","display_name":"Waffo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Waffo","raw_affiliation_strings":["Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110056601","display_name":"Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miller","raw_affiliation_strings":["Research Instrumentation Facility, Auburn University, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Instrumentation Facility, Auburn University, AL, USA","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102862152","display_name":"Komal Vig","orcid":"https://orcid.org/0000-0002-5280-8920","observed_orcids":["https://orcid.org/0000-0002-5280-8920"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Komal Vig","raw_affiliation_strings":["Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063851790","display_name":"Vida A. Dennis","orcid":"https://orcid.org/0000-0003-1409-5605","observed_orcids":["https://orcid.org/0000-0003-1409-5605"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vida Dennis","raw_affiliation_strings":["Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080459233","display_name":"Erdal Ero\u011flu","orcid":"https://orcid.org/0000-0001-7281-3906","observed_orcids":["https://orcid.org/0000-0001-7281-3906"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erdal Ero\u011flu","raw_affiliation_strings":["Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL 36104, USA","Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL 36104, USA","institution_ids":["https://openalex.org/I145611464"]},{"raw_affiliation_string":"Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA","institution_ids":["https://openalex.org/I145611464"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055418907"],"corresponding_institution_ids":["https://openalex.org/I145611464"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":1.3432,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.79555957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":null,"first_page":"1403","last_page":"1403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonviral-gene-delivery","display_name":"non-viral gene delivery","score":0.8980000019073486},{"id":"https://openalex.org/keywords/poly-2-hydroxyethyl-methacrylate","display_name":"poly(2-hydroxyethyl methacrylate)","score":0.9129999876022339},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.5210000276565552},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.8190000057220459},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.8220348358154297},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.7058048248291016},{"id":"https://openalex.org/C195856716","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"Naked DNA","level":4,"score":0.5480983853340149},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5373865962028503},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.526938796043396},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.388655424118042},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3719427287578583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36141669750213623},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34893885254859924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34004634618759155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18346217274665833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12877869606018066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011102","descriptor_name":"Polyhydroxyethyl Methacrylate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011102","descriptor_name":"Polyhydroxyethyl Methacrylate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012136","descriptor_name":"Respiratory Syncytial Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022261","descriptor_name":"Respiratory Syncytial Virus Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054118","descriptor_name":"Nanospheres","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D054118","descriptor_name":"Nanospheres","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.2147/ijn.s43168","doi":"https://doi.org/10.2147/ijn.s43168","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s43168","pdf_url":"https://www.dovepress.com/getfile.php?fileID=15747","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2628250","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3629879","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3629879","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3629879","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmid:23610520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23610520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:89c54a5ee936450893ee2e64a0a13dae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/89c54a5ee936450893ee2e64a0a13dae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol 2013, Iss default, Pp 1403-1415 (2013)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/12726","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/a-nonviral-phemachitosan-nanosphere-mediated-high-efficiency-gene-deli-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s43168","doi":"https://doi.org/10.2147/ijn.s43168","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s43168","pdf_url":"https://www.dovepress.com/getfile.php?fileID=15747","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1918392589","display_name":"RISE Option II:NIGMS-Research Initiative for Scientific Enhancement (RISE) Program at ASU","funder_award_id":"R25GM106995","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G354268126","display_name":"Center for NanoBiotechnology Research","funder_award_id":"1241701","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7632187719","display_name":"Implementation Grant: Computational Biology and NanoBiotechnology Undergraduate Research and Education (CNURE)","funder_award_id":"1135863","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2030907941.pdf","grobid_xml":"https://content.openalex.org/works/W2030907941.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1983207184","https://openalex.org/W1985242626","https://openalex.org/W1991178356","https://openalex.org/W1993844364","https://openalex.org/W1997527149","https://openalex.org/W2000066381","https://openalex.org/W2004180909","https://openalex.org/W2007713229","https://openalex.org/W2009993736","https://openalex.org/W2010581068","https://openalex.org/W2020093934","https://openalex.org/W2022780718","https://openalex.org/W2033530261","https://openalex.org/W2035074920","https://openalex.org/W2040979815","https://openalex.org/W2041621912","https://openalex.org/W2044486914","https://openalex.org/W2044954256","https://openalex.org/W2046406980","https://openalex.org/W2050363129","https://openalex.org/W2055944585","https://openalex.org/W2058580808","https://openalex.org/W2060452648","https://openalex.org/W2064184046","https://openalex.org/W2068740565","https://openalex.org/W2069763972","https://openalex.org/W2070803308","https://openalex.org/W2077364459","https://openalex.org/W2078397260","https://openalex.org/W2081380540","https://openalex.org/W2094478767","https://openalex.org/W2112607530","https://openalex.org/W2115513954","https://openalex.org/W2141839114","https://openalex.org/W2153740170","https://openalex.org/W2312533584","https://openalex.org/W2327460498","https://openalex.org/W4255549647"],"related_works":["https://openalex.org/W7100453315","https://openalex.org/W2999357102","https://openalex.org/W2133214818","https://openalex.org/W2115009090","https://openalex.org/W4415689268","https://openalex.org/W2077370946","https://openalex.org/W2045474746","https://openalex.org/W3031218191","https://openalex.org/W2061579723","https://openalex.org/W2022093429"],"abstract_inverted_index":{"The":[0,98],"transport":[1],"of":[2,10,20,68,84,103,112,167,176,192,214,228],"DNA":[3,21,96],"into":[4,206],"eukaryotic":[5,51,106],"cells":[6],"is":[7],"minimal":[8],"because":[9],"the":[11,18,50,55,110,133,142,165,174,189,193,215,223,226,229],"cell":[12,52,107,124,145],"membrane":[13,146],"barrier,":[14],"and":[15,25,32,78,127,147,172,184,239],"this":[16,39,81,218],"limits":[17],"application":[19,227],"vaccines,":[22],"gene":[23,26,90,202,235],"silencing,":[24],"therapy.":[27],"Several":[28],"available":[29],"transfection":[30,115,168,179,190],"reagents":[31],"techniques":[33],"have":[34,45],"been":[35,46],"used":[36,80],"to":[37,48,139,141],"circumvent":[38],"problem.":[40],"Alternatively,":[41],"nonviral":[42],"nanoscale":[43],"vectors":[44],"shown":[47],"bypass":[49],"membrane.":[53],"In":[54,217],"present":[56],"work,":[57],"we":[58,79,129,162,220],"developed":[59],"a":[60,74,85,95,113,177,232],"unique":[61],"nanomaterial,":[62],"pHEMA+chitosan":[63],"nanospheres":[64,71],"(PCNSs),":[65],"which":[66],"consisted":[67],"poly(2-hydroxyethyl":[69],"methacrylate)":[70],"surrounded":[72],"by":[73,151],"chitosan":[75],"cationic":[76],"shell,":[77],"for":[82,94,222,234],"encapsulation":[83],"respiratory":[86],"syncytial":[87],"virus":[88],"(RSV)-F":[89],"construct":[91],"(a":[92],"model":[93],"vaccine).":[97],"new":[99],"nanomaterial":[100],"was":[101],"capable":[102],"transfecting":[104],"various":[105],"lines":[108],"without":[109,173],"use":[111,175],"commercial":[114],"reagent.":[116],"Using":[117,156],"transmission":[118],"electron":[119],"microscopy,":[120],"(TEM),":[121],"fluorescence":[122],"activated":[123],"sorting":[125],"(FACS),":[126],"immunofluorescence,":[128],"clearly":[130],"demonstrated":[131],"that":[132],"positively":[134],"charged":[135,144],"PCNSs":[136,171,194,230],"were":[137,148,203],"able":[138],"bind":[140],"negatively":[143],"taken":[149],"up":[150],"endocytosis,":[152],"in":[153,181,195,210,237,240],"Cos-7":[154],"cells.":[155,186],"quantitative":[157],"polymerase":[158],"chain":[159],"reaction":[160],"(qPCR),":[161],"also":[163],"evaluated":[164],"efficiency":[166,191],"achieved":[169],"with":[170],"liposomal-based":[178],"mediator,":[180],"Cos-7,":[182],"HEp-2,":[183],"Vero":[185],"To":[187],"assess":[188],"vivo,":[196],"these":[197],"novel":[198],"nanomaterials":[199],"containing":[200],"RSV-F":[201],"injected":[204],"intramuscularly":[205],"BALB/c":[207],"mice,":[208],"resulting":[209],"high":[211],"copy":[212],"number":[213],"transgene.":[216],"study,":[219],"report,":[221],"first":[224],"time,":[225],"as":[231],"nanovehicle":[233],"delivery":[236],"vitro":[238],"vivo.":[241]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}