{"id":"https://openalex.org/W2030746292","doi":"https://doi.org/10.1002/bies.20709","title":"Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging","display_name":"Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging","publication_year":2008,"publication_date":"2008-01-15","ids":{"openalex":"https://openalex.org/W2030746292","doi":"https://doi.org/10.1002/bies.20709","mag":"2030746292","pmid":"https://pubmed.ncbi.nlm.nih.gov/18200563"},"language":"en","primary_location":{"id":"doi:10.1002/bies.20709","doi":"https://doi.org/10.1002/bies.20709","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.20709","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031262501","display_name":"Nathan A. DeCarolis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan A. DeCarolis","raw_affiliation_strings":["Department of Psychiatry, The University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027262882","display_name":"Keith A. Wharton","orcid":"https://orcid.org/0000-0003-0374-1114","observed_orcids":["https://orcid.org/0000-0003-0374-1114"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith A. Wharton","raw_affiliation_strings":["Department of Molecular Biology, The University of Texas, Southwestern Medical Center, Dallas, TX","Department of Pathology The University of Texas, Southwestern Medical Center, Dallas, TX","University of Texas Southwestern Medical Center","University of Texas at Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The University of Texas, Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pathology The University of Texas, Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060118711","display_name":"Amelia J. Eisch","orcid":"https://orcid.org/0000-0001-6476-5385","observed_orcids":["https://orcid.org/0000-0001-6476-5385"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amelia J. Eisch","raw_affiliation_strings":["Department of Psychiatry, The University of Texas, Southwestern Medical Center, Dallas, TX","Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The University of Texas, Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Psychiatry","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060118711"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.2243,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.1876862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"2","first_page":"102","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cellular-aging","display_name":"cellular aging","score":0.9190000295639038},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/age-related-deficits","display_name":"age-related deficits","score":0.6830000281333923},{"id":"https://openalex.org/keywords/stem-cell-maintenance","display_name":"stem cell maintenance","score":0.925000011920929},{"id":"https://openalex.org/keywords/fate-determination","display_name":"fate determination","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9720045328140259},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.5825717449188232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.557817280292511},{"id":"https://openalex.org/C182819311","wikidata":"https://www.wikidata.org/wiki/Q18028670","display_name":"LRP5","level":4,"score":0.518328070640564},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5077520608901978},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4905192255973816},{"id":"https://openalex.org/C2778023678","wikidata":"https://www.wikidata.org/wiki/Q554403","display_name":"Duality (order theory)","level":2,"score":0.421853244304657},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0698179304599762},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bies.20709","doi":"https://doi.org/10.1002/bies.20709","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.20709","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},{"id":"pmid:18200563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18200563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays : news and reviews in molecular, cellular and developmental biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1625966995","https://openalex.org/W1631908837","https://openalex.org/W1837181255","https://openalex.org/W1978888457","https://openalex.org/W1982255694","https://openalex.org/W1989456936","https://openalex.org/W1993677820","https://openalex.org/W1993975781","https://openalex.org/W1996499871","https://openalex.org/W2001750225","https://openalex.org/W2015536677","https://openalex.org/W2023256466","https://openalex.org/W2024209230","https://openalex.org/W2031919201","https://openalex.org/W2032168674","https://openalex.org/W2032867856","https://openalex.org/W2034581921","https://openalex.org/W2035258932","https://openalex.org/W2039093900","https://openalex.org/W2041940571","https://openalex.org/W2043691868","https://openalex.org/W2050222325","https://openalex.org/W2055746941","https://openalex.org/W2062578421","https://openalex.org/W2065961022","https://openalex.org/W2073952925","https://openalex.org/W2075318195","https://openalex.org/W2075387442","https://openalex.org/W2076155053","https://openalex.org/W2078281194","https://openalex.org/W2095509297","https://openalex.org/W2096711478","https://openalex.org/W2097142631","https://openalex.org/W2107648723","https://openalex.org/W2113238381","https://openalex.org/W2114360920","https://openalex.org/W2121652346","https://openalex.org/W2124153237","https://openalex.org/W2124898423","https://openalex.org/W2129720310","https://openalex.org/W2133965606","https://openalex.org/W2155507705","https://openalex.org/W2166395934"],"related_works":["https://openalex.org/W3128547036","https://openalex.org/W1996111260","https://openalex.org/W2107825767","https://openalex.org/W2913541467","https://openalex.org/W2022351074","https://openalex.org/W2935254431","https://openalex.org/W3159453404","https://openalex.org/W2128515533","https://openalex.org/W4307544679","https://openalex.org/W2399252004"],"abstract_inverted_index":{"Critical":[0],"cellular":[1,10,37],"functions,":[2],"including":[3],"stem":[4],"cell":[5],"maintenance,":[6],"fate":[7],"determination,":[8],"and":[9,68,86],"behavior,":[11],"are":[12],"governed":[13],"by":[14,27],"canonical":[15,33],"Wnt":[16,34,43,54,71,84],"signaling,":[17],"an":[18,62],"evolutionarily":[19],"conserved":[20],"pathway":[21],"whose":[22],"intracellular":[23],"signal":[24],"is":[25],"transduced":[26],"beta-catentin.":[28],"Emerging":[29],"evidence":[30],"suggests":[31],"that":[32,40,53],"signaling":[35,44,55,72,85],"influences":[36],"aging,":[38,74],"indicating":[39],"increases":[41],"in":[42],"delay":[45],"age-related":[46],"deficits.1":[47],"However,":[48],"recent":[49],"Science":[50],"papers":[51],"suggest":[52],"accelerates":[56],"the":[57],"onset":[58],"of":[59,80],"aging.2,3":[60],"In":[61],"attempt":[63],"to":[64,83],"resolve":[65],"this":[66],"paradox":[67],"clarify":[69],"how":[70],"affects":[73],"we":[75],"provide":[76],"a":[77],"selective":[78],"review":[79],"research":[81],"relevant":[82],"aging.":[87]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}