{"id":"https://openalex.org/W2030360548","doi":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.0.co;2-f","title":"A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration","display_name":"A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W2030360548","doi":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.0.co;2-f","mag":"2030360548","pmid":"https://pubmed.ncbi.nlm.nih.gov/9373729"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291099-081X%28199711%2918%3A8%3C727%3A%3AAID-BDD58%3E3.0.CO%3B2-F","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108532817","display_name":"Yow\u2010Shieng Uang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yow-Shieng Uang","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmacy, Taipei Medical College, Taiwan","Department of Pharmaceutics, School of Pharmacy, Taipei Medical College, 250 Wu-Hsing St., Taipei 10502, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, Taipei Medical College, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, Taipei Medical College, 250 Wu-Hsing St., Taipei 10502, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111557441","display_name":"Kuang-Yang Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kuang-Yang Hsu","raw_affiliation_strings":["Department of Pharmaceutics, School of Pharmacy, Taipei Medical College, 250 Wu-Hsing St., Taipei 10502, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, Taipei Medical College, 250 Wu-Hsing St., Taipei 10502, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111557441"],"corresponding_institution_ids":["https://openalex.org/I47519274"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.3878,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.56384577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"8","first_page":"727","last_page":"736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeic-acid","display_name":"caffeic acid","score":1.0},{"id":"https://openalex.org/keywords/nonlinear-pharmacokinetics","display_name":"nonlinear pharmacokinetics","score":0.9559999704360962},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.7059999704360962},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.8180000185966492},{"id":"https://openalex.org/keywords/total-body-clearance","display_name":"body clearance","score":0.8679999709129333},{"id":"https://openalex.org/keywords/elimination-rate-constant","display_name":"elimination rate constant","score":0.703000009059906},{"id":"https://openalex.org/keywords/mean-residence-time","display_name":"mean residence time","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.8790000081062317},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.871999979019165},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.7919999957084656},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8697535991668701},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7141374349594116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7061939835548401},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6622825860977173},{"id":"https://openalex.org/C192670549","wikidata":"https://www.wikidata.org/wiki/Q5361061","display_name":"Elimination rate constant","level":4,"score":0.6574952602386475},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.6459953784942627},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.4940994083881378},{"id":"https://openalex.org/C3941253","wikidata":"https://www.wikidata.org/wiki/Q47270","display_name":"Half-life","level":3,"score":0.4300963878631592},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42384248971939087},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.41882503032684326},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40627825260162354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3516266942024231},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.3389967083930969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19975367188453674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11052632331848145},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.10871750116348267},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.3.co;2-6","doi":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.3.co;2-6","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.3.co;2-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291099-081X%28199711%2918%3A8%3C727%3A%3AAID-BDD58%3E3.0.CO%3B2-F","source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},{"id":"pmid:9373729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9373729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics & drug disposition","raw_type":"Comparative Study"},{"id":"pmh:oai:localhost:987654321/8966","doi":null,"is_oa":false,"landing_page_url":"http://libir.tmu.edu.tw/handle/987654321/8966","pdf_url":null,"source":{"id":"https://openalex.org/S4406923063","display_name":"Taipei Medical University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:libir.tmu.edu.tw:123456789/22952","doi":null,"is_oa":false,"landing_page_url":"https://203.71.86.71/handle/123456789/22952","pdf_url":null,"source":{"id":"https://openalex.org/S4406923063","display_name":"Taipei Medical University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.3.co;2-6","doi":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.3.co;2-6","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199711)18:8<727::aid-bdd58>3.3.co;2-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291099-081X%28199711%2918%3A8%3C727%3A%3AAID-BDD58%3E3.0.CO%3B2-F","source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2030360548.pdf","grobid_xml":"https://content.openalex.org/works/W2030360548.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2384589881","https://openalex.org/W7112254851","https://openalex.org/W2255309315","https://openalex.org/W2053490330","https://openalex.org/W2471803559","https://openalex.org/W7113661608","https://openalex.org/W1939884652","https://openalex.org/W7113126149","https://openalex.org/W2489099013","https://openalex.org/W1977704840"],"abstract_inverted_index":{"The":[0,27,42,97,125,195],"dose-dependent":[1],"pharmacokinetics":[2],"of":[3,107,112,127,142,222],"caffeic":[4,115,129],"acid":[5,116,130],"(CA)":[6],"were":[7,20,63,90,167],"studied":[8],"in":[9,119,132,158,198,225],"rabbits.":[10],"Three":[11],"different":[12],"doses":[13,141,215],"(5,":[14],"10,":[15,144],"and":[16,48,79,138,145,162,186,204,212,228],"25":[17,146],"mg":[18,60,87,109,147,172,209],"kg-1)":[19],"administered":[21],"intravenously":[22],"to":[23,176],"six":[24],"rabbits":[25],"each.":[26],"concentration-time":[28],"profiles":[29],"for":[30,39],"CA":[31],"could":[32],"be":[33,217],"fitted":[34],"by":[35],"a":[36,58,85,170,207],"two-compartment":[37],"model":[38],"each":[40],"dose.":[41],"results":[43],"showed":[44,191],"that":[45],"total-body":[46,199],"clearance":[47,227],"elimination":[49,75],"rate":[50,165,189,231],"constant":[51],"from":[52],"the":[53,68,73,94,105,113,120,133,159,177,181,213,220,223],"central":[54],"compartment":[55],"(k10)":[56],"after":[57,67,84,93,140],"5":[59,86,171,208],"kg-1":[61,88,173,210],"dose":[62,89,103,174,211],"greater":[64],"than":[65,92],"those":[66],"other":[69,95,178,182,214],"two":[70],"doses.":[71,96,179],"Furthermore,":[72],"terminal":[74],"half-life":[76],"(beta":[77],"half-life)":[78],"mean":[80],"residence":[81],"time":[82],"(MRT)":[83],"less":[91],"AUC":[98],"value":[99],"increased":[100],"linearly":[101],"with":[102,169],"within":[104,122],"range":[106],"10-25":[108],"kg-1.":[110],"Most":[111],"unchanged":[114,128],"was":[117,135,151],"excreted":[118,131],"urine":[121,134],"2":[123],"h.":[124],"percentage":[126],"63.4,":[136],"60.0,":[137],"55.4%":[139],"5,":[143],"kg-1,":[148],"respectively,":[149],"which":[150],"not":[152],"significantly":[153],"different.":[154],"However,":[155],"significant":[156],"differences":[157,196,224],"renal":[160,163,226,229],"clearances":[161,185],"excretion":[164,188,230],"constants":[166,190],"observed":[168,197],"compared":[175],"On":[180],"hand,":[183],"nonrenal":[184,187],"no":[192],"dose-related":[193],"differences.":[194],"clearance,":[200],"k10,":[201],"beta":[202],"half-life,":[203],"MRT":[205],"between":[206],"can":[216],"explained":[218],"on":[219],"basis":[221],"constants.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}