{"id":"https://openalex.org/W2030315751","doi":"https://doi.org/10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","title":"Long-term analysis of colonic aberrant crypt formation after treatment of Sprague-Dawley rats with azoxymethane","display_name":"Long-term analysis of colonic aberrant crypt formation after treatment of Sprague-Dawley rats with azoxymethane","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2030315751","doi":"https://doi.org/10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","mag":"2030315751","pmid":"https://pubmed.ncbi.nlm.nih.gov/9804274"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","doi":"https://doi.org/10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291520-6866%281998%2918%3A4%3C183%3A%3AAID-TCM4%3E3.0.CO%3B2-D","source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291520-6866%281998%2918%3A4%3C183%3A%3AAID-TCM4%3E3.0.CO%3B2-D","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112331339","display_name":"MARGARET J. DAVIES","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134707","display_name":"Bibra International","ror":"https://ror.org/03hvxkc45","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210134707"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M.J. Davies","raw_affiliation_strings":["Department of Molecular Biology, BIBRA International, Carshalton, Surrey, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, BIBRA International, Carshalton, Surrey, England","institution_ids":["https://openalex.org/I4210134707"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004653389","display_name":"Paul C. Rumsby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134707","display_name":"Bibra International","ror":"https://ror.org/03hvxkc45","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210134707"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"P.C. Rumsby","raw_affiliation_strings":["Department of Molecular Biology, BIBRA International, Carshalton, Surrey, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, BIBRA International, Carshalton, Surrey, England","institution_ids":["https://openalex.org/I4210134707"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004653389"],"corresponding_institution_ids":["https://openalex.org/I4210134707"],"apc_list":null,"apc_paid":null,"fwci":1.5349,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8323827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"4","first_page":"183","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.3578999936580658,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aberrant-crypt-foci","display_name":"aberrant crypt foci","score":0.8560000061988831},{"id":"https://openalex.org/keywords/azoxymethane","display_name":"azoxymethane","score":0.9409999847412109},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.49900001287460327},{"id":"https://openalex.org/keywords/ki-ras-mutation","display_name":"Ki-ras mutation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pituitary-microadenoma","display_name":"pituitary microadenoma","score":0.6320000290870667},{"id":"https://openalex.org/keywords/colonic-polyps","display_name":"colonic polyps","score":0.7860000133514404},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tumor-multiplicity","display_name":"tumor multiplicity","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.9906092882156372},{"id":"https://openalex.org/C2780669762","wikidata":"https://www.wikidata.org/wiki/Q4667164","display_name":"Aberrant crypt foci","level":5,"score":0.7164846658706665},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.694312572479248},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5908649563789368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39826130867004395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3528241217136383},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32301628589630127},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.19991809129714966},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.1407361626625061},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09954437613487244},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05291476845741272},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001397","descriptor_name":"Azoxymethane","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","doi":"https://doi.org/10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291520-6866%281998%2918%3A4%3C183%3A%3AAID-TCM4%3E3.0.CO%3B2-D","source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},{"id":"pmid:9804274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9804274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, carcinogenesis, and mutagenesis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","doi":"https://doi.org/10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1998)18:4<183::aid-tcm4>3.0.co;2-d","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291520-6866%281998%2918%3A4%3C183%3A%3AAID-TCM4%3E3.0.CO%3B2-D","source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334633","display_name":"World Cancer Research Fund","ror":"https://ror.org/02gc7qc02"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2030315751.pdf","grobid_xml":"https://content.openalex.org/works/W2030315751.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088033808","https://openalex.org/W7096832807","https://openalex.org/W1995714303","https://openalex.org/W2038701648","https://openalex.org/W2415750963","https://openalex.org/W1966604733","https://openalex.org/W1907210134","https://openalex.org/W1546332065","https://openalex.org/W7101128220","https://openalex.org/W2408930718"],"abstract_inverted_index":{"Human":[0],"colon":[1,33,50,79,147,201,324],"cancer":[2,34,51,80,325],"is":[3,289],"a":[4,13,25,44,56,149,282],"multistage":[5],"disease":[6],"which":[7,36,239],"has":[8,23],"been":[9],"shown":[10],"to":[11,111,157,241,251,306,330],"have":[12],"number":[14,189],"of":[15,27,32,58,66,78,99,116,145,148,179,190,260,323],"well-defined":[16],"histological":[17],"and":[18,39,131,159,202,226,231,237,246,293,311],"genetic":[19,298],"events.":[20],"This":[21,161],"knowledge":[22],"identified":[24],"series":[26],"stages":[28,72],"in":[29,35,52,74,81,108,141,164,182,244,256,269,300,316,320,326],"the":[30,53,63,67,71,75,113,117,142,146,165,177,180,188,200,252,261,276,297,301,307,321,327],"development":[31,65,77,115,322],"dietary":[37],"components":[38],"chemicals":[40],"may":[41,280,303],"play":[42],"either":[43,90],"beneficial":[45],"or":[46,92],"detrimental":[47],"role.":[48],"Azoxymethane-induced":[49],"rat":[54,302,328],"represents":[55],"way":[57],"investigating":[59],"such":[60],"effects":[61],"on":[62],"temporal":[64],"disease.":[68,119],"To":[69],"assess":[70],"involved":[73],"long-term":[76],"this":[82,292],"animal":[83],"model,":[84],"Sprague-Dawley":[85],"rats":[86],"were":[87,106,129,134,169,197,209],"treated":[88],"with":[89,174,217],"one":[91],"two":[93],"(given":[94],"24":[95],"hours":[96],"apart)":[97],"doses":[98,105],"azoxymethane":[100],"(15":[101],"mg/kg).":[102],"These":[103,272],"low":[104],"chosen":[107],"an":[109],"attempt":[110],"mimic":[112],"slow":[114],"human":[118],"At":[120],"varying":[121],"time":[122],"intervals":[123],"(5-84":[124],"weeks)":[125],"after":[126],"treatment,":[127],"animals":[128],"killed":[130],"their":[132],"colons":[133],"examined":[135],"for":[136,211],"lesions.":[137,271],"Evidence":[138],"was":[139,176,204],"found":[140,315],"distal":[143],"region":[144,166,255],"progression":[150,162,299],"from":[151,199,291,313],"early":[152],"alterations":[153],"(aberrant":[154],"crypt":[155,192,263,278],"foci)":[156],"microadenomas":[158],"polyps.":[160],"occurs":[163],"where":[167],"carcinomas":[168],"found.":[170],"The":[171,194,206],"best":[172],"correlation":[173],"tumorigenicity":[175],"multiplicity":[178],"crypts":[181,196],"each":[183],"focus":[184,279],"rather":[185],"than":[186],"simply":[187],"aberrant":[191,195,262,277],"foci.":[193],"microdissected":[198],"DNA":[203],"prepared.":[205],"following":[207],"genes":[208,319],"screened":[210],"mutation":[212,253],"using":[213],"polymerase":[214],"chain":[215],"reaction":[216],"single-strand":[218],"conformation":[219],"polymorphism,":[220],"oligonucleotide":[221],"hybridisation,":[222],"restriction":[223],"site":[224],"changes":[225],"sequencing:":[227],"Ki-ras":[228],"(exons":[229,234],"1":[230],"2),":[232],"p53":[233],"5,":[235],"6,":[236],"7":[238],"correspond":[240],"exons":[242],"5-8":[243],"humans),":[245],"APC":[247],"(exon":[248],"15":[249],"corresponding":[250],"cluster":[254],"humans).":[257],"Extensive":[258],"studies":[259,295],"foci":[264],"formed":[265],"revealed":[266],"no":[267],"mutations":[268],"these":[270],"results":[273],"suggest":[274],"that":[275,296,314],"be":[281,331],"useful":[283],"short-term":[284],"preneoplastic":[285],"marker.":[286],"However,":[287],"it":[288],"clear":[290],"other":[294],"vary":[304],"according":[305],"treatment":[308],"regimen":[309],"used":[310],"differs":[312],"human.":[317],"Key":[318],"remain":[329],"elucidated.":[332]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}