{"id":"https://openalex.org/W2030253166","doi":"https://doi.org/10.1016/j.toxlet.2005.11.009","title":"Involvement of reactive oxygen species in the immunosuppressive effect of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), a food-born carcinogenic heterocyclic amine","display_name":"Involvement of reactive oxygen species in the immunosuppressive effect of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), a food-born carcinogenic heterocyclic amine","publication_year":2006,"publication_date":"2006-01-05","ids":{"openalex":"https://openalex.org/W2030253166","doi":"https://doi.org/10.1016/j.toxlet.2005.11.009","mag":"2030253166","pmid":"https://pubmed.ncbi.nlm.nih.gov/16386858"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxlet.2005.11.009","doi":"https://doi.org/10.1016/j.toxlet.2005.11.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2005.11.009","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101776194","display_name":"Cheol\u2010Heui Yun","orcid":"https://orcid.org/0000-0002-0041-2887","observed_orcids":["https://orcid.org/0000-0002-0041-2887"]},"institutions":[{"id":"https://openalex.org/I1309827724","display_name":"International Vaccine Institute","ror":"https://ror.org/02yfanq70","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I1309827724"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Cheol-Heui Yun","raw_affiliation_strings":["Laboratory Sciences Division, International Vaccine Institute, SNU Research Park, San 4-8 Boncheon-7 dong, Kwanak-gu, Seoul 151-818, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Sciences Division, International Vaccine Institute, SNU Research Park, San 4-8 Boncheon-7 dong, Kwanak-gu, Seoul 151-818, Republic of Korea","institution_ids":["https://openalex.org/I1309827724","https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103984696","display_name":"Dae Kyun Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae Kyun Chung","raw_affiliation_strings":["RNA Inc., Suwon 449-701, Republic of Korea","School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Suwon 449-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RNA Inc., Suwon 449-701, Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Suwon 449-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047552287","display_name":"Kristopher Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1309827724","display_name":"International Vaccine Institute","ror":"https://ror.org/02yfanq70","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I1309827724"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kristopher Yoon","raw_affiliation_strings":["Laboratory Sciences Division, International Vaccine Institute, SNU Research Park, San 4-8 Boncheon-7 dong, Kwanak-gu, Seoul 151-818, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Sciences Division, International Vaccine Institute, SNU Research Park, San 4-8 Boncheon-7 dong, Kwanak-gu, Seoul 151-818, Republic of Korea","institution_ids":["https://openalex.org/I1309827724","https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102007547","display_name":"Seung Hyun Han","orcid":"https://orcid.org/0009-0000-3382-0660","observed_orcids":["https://orcid.org/0009-0000-3382-0660"]},"institutions":[{"id":"https://openalex.org/I1309827724","display_name":"International Vaccine Institute","ror":"https://ror.org/02yfanq70","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I1309827724"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seung Hyun Han","raw_affiliation_strings":["Laboratory Sciences Division, International Vaccine Institute, SNU Research Park, San 4-8 Boncheon-7 dong, Kwanak-gu, Seoul 151-818, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Sciences Division, International Vaccine Institute, SNU Research Park, San 4-8 Boncheon-7 dong, Kwanak-gu, Seoul 151-818, Republic of Korea","institution_ids":["https://openalex.org/I1309827724","https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102007547"],"corresponding_institution_ids":["https://openalex.org/I1309827724","https://openalex.org/I139264467"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":0.2523,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.57347283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"164","issue":"1","first_page":"37","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.27950000762939453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trp-p-1","display_name":"Trp-P-1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8309999704360962},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9909999966621399},{"id":"https://openalex.org/keywords/heterocyclic-amines","display_name":"heterocyclic amines","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dietary-carcinogens","display_name":"food carcinogens","score":0.9160000085830688},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.6610000133514404},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":1.0},{"id":"https://openalex.org/keywords/nf-kappab-binding","display_name":"NF-kappaB binding","score":0.7720000147819519},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8090000152587891},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.972000002861023},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ionomycin","display_name":"ionomycin","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.7690658569335938},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.6825296878814697},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.612546443939209},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5974794626235962},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5784858465194702},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5769505500793457},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5478744506835938},{"id":"https://openalex.org/C2777278644","wikidata":"https://www.wikidata.org/wiki/Q2758348","display_name":"Heterocyclic amine","level":3,"score":0.5361784100532532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5171307921409607},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4971785843372345},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.49315232038497925},{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.4724472165107727},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4305896759033203},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38530418276786804},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3760633170604706},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3233659267425537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29055213928222656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2380795180797577},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07806810736656189},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005506","descriptor_name":"Food Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.toxlet.2005.11.009","doi":"https://doi.org/10.1016/j.toxlet.2005.11.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2005.11.009","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},{"id":"pmid:16386858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16386858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1532140481","https://openalex.org/W1568529372","https://openalex.org/W1603650405","https://openalex.org/W1786911182","https://openalex.org/W1945689998","https://openalex.org/W1965865448","https://openalex.org/W1967195855","https://openalex.org/W1972952746","https://openalex.org/W1975676339","https://openalex.org/W1975709514","https://openalex.org/W1980999562","https://openalex.org/W1986301169","https://openalex.org/W1995317658","https://openalex.org/W2026553348","https://openalex.org/W2033997026","https://openalex.org/W2035037271","https://openalex.org/W2039894038","https://openalex.org/W2065130315","https://openalex.org/W2069401800","https://openalex.org/W2072878276","https://openalex.org/W2074040460","https://openalex.org/W2075281860","https://openalex.org/W2078191448","https://openalex.org/W2087891393","https://openalex.org/W2095526291","https://openalex.org/W2118894711","https://openalex.org/W2124983348","https://openalex.org/W2135344763","https://openalex.org/W2144949964","https://openalex.org/W2145206543","https://openalex.org/W2146578818","https://openalex.org/W2159968022","https://openalex.org/W2415609596","https://openalex.org/W6631995498"],"related_works":["https://openalex.org/W2087891393","https://openalex.org/W2489679597","https://openalex.org/W2039894038","https://openalex.org/W2480168400","https://openalex.org/W2188091126","https://openalex.org/W2078191448","https://openalex.org/W2003078659","https://openalex.org/W1503397342","https://openalex.org/W2484473388","https://openalex.org/W2069267044"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
