{"id":"https://openalex.org/W20302444","doi":null,"title":"Erythromycin: a motilin agonist and gastrointestinal prokinetic agent.","display_name":"Erythromycin: a motilin agonist and gastrointestinal prokinetic agent.","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W20302444","mag":"20302444","pmid":"https://pubmed.ncbi.nlm.nih.gov/8470625"},"language":"en","primary_location":{"id":"pmid:8470625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8470625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103870661","display_name":"Frederick H. Weber","orcid":"https://orcid.org/0000-0001-9739-6125","observed_orcids":["https://orcid.org/0000-0001-9739-6125"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F H Weber","raw_affiliation_strings":["Department of Medicine, University of Virginia Health Sciences Center, Charlottesville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Virginia Health Sciences Center, Charlottesville","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071471114","display_name":"Robert D. Richards","orcid":"https://orcid.org/0000-0001-7043-8372","observed_orcids":["https://orcid.org/0000-0001-7043-8372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Richards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005028574","display_name":"Richard W. McCallum","orcid":"https://orcid.org/0000-0002-6652-8049","observed_orcids":["https://orcid.org/0000-0002-6652-8049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R W McCallum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1631,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.95552108,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"88","issue":"4","first_page":"485","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":1.0},{"id":"https://openalex.org/keywords/motilin-agonist","display_name":"motilin agonist","score":0.859000027179718},{"id":"https://openalex.org/keywords/prokinetic-agents","display_name":"prokinetic agents","score":0.925000011920929},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.847000002861023},{"id":"https://openalex.org/keywords/motilin-receptor","display_name":"motilin receptor","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C131793682","wikidata":"https://www.wikidata.org/wiki/Q126440","display_name":"Motilin","level":2,"score":0.9881294369697571},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.8825216293334961},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6949809193611145},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6456880569458008},{"id":"https://openalex.org/C2777951760","wikidata":"https://www.wikidata.org/wiki/Q5526842","display_name":"Gastrointestinal hormone","level":4,"score":0.5783023834228516},{"id":"https://openalex.org/C2777247143","wikidata":"https://www.wikidata.org/wiki/Q1429522","display_name":"Prokinetic agent","level":2,"score":0.5324172973632812},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.527306079864502},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5269582867622375},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5081470012664795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4604308009147644},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3073505163192749},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23840004205703735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17812588810920715},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.1296273171901703},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.12451741099357605},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005746","descriptor_name":"Gastric Emptying","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009037","descriptor_name":"Motilin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011964","descriptor_name":"Receptors, Gastrointestinal Hormone","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018013","descriptor_name":"Receptors, Neuropeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8470625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8470625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:20302444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8470625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412217772","https://openalex.org/W2169510551","https://openalex.org/W2079731741","https://openalex.org/W1968123464","https://openalex.org/W2417728257","https://openalex.org/W2084037001","https://openalex.org/W7098163740","https://openalex.org/W7100601859","https://openalex.org/W2474581463","https://openalex.org/W2409535334"],"abstract_inverted_index":{"Erythromycin,":[0],"a":[1,9,16,63],"commonly":[2],"used":[3],"antibiotic,":[4],"has":[5],"recently":[6],"emerged":[7],"as":[8],"potential":[10],"gastrointestinal":[11,25,36,54,69,93],"prokinetic":[12,70],"agent.":[13],"This":[14],"follows":[15],"decade":[17],"of":[18,23,28,68,81,86,92,100],"research":[19],"into":[20],"the":[21,50,53,84,87,98],"mechanism":[22],"well-recognized":[24],"side":[26],"effects":[27],"erythromycin.":[29],"Early":[30],"investigations":[31],"demonstrated":[32],"that":[33,43,62],"erythromycin":[34,75],"increased":[35],"motility,":[37],"and":[38,48,65,76,89],"more":[39],"recent":[40],"studies":[41],"suggest":[42],"it":[44,60],"fortuitously":[45],"binds":[46],"to":[47],"stimulates":[49],"receptor":[51],"for":[52],"peptide":[55],"motilin.":[56],"From":[57],"this":[58],"work":[59],"appears":[61],"new":[64],"powerful":[66],"class":[67],"agents":[71],"will":[72],"evolve":[73],"from":[74],"its":[77],"derivatives.":[78],"The":[79],"role":[80],"motilin":[82,102],"in":[83],"genesis":[85],"fasting":[88],"fed":[90],"patterns":[91],"motility":[94],"is":[95],"emerging":[96],"through":[97],"study":[99],"these":[101],"agonists.":[103]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
