{"id":"https://openalex.org/W2030242575","doi":"https://doi.org/10.3791/50671","title":"A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent","display_name":"A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2030242575","doi":"https://doi.org/10.3791/50671","mag":"2030242575","pmid":"https://pubmed.ncbi.nlm.nih.gov/24300285","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3969050"},"language":"en","primary_location":{"id":"doi:10.3791/50671","doi":"https://doi.org/10.3791/50671","is_oa":true,"landing_page_url":"https://doi.org/10.3791/50671","pdf_url":"https://www.jove.com/pdf/50671/a-microplate-assay-to-assess-chemical-effects-on-rbl-2h3-mast-cell","source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jove.com/pdf/50671/a-microplate-assay-to-assess-chemical-effects-on-rbl-2h3-mast-cell","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003146474","display_name":"Lisa M. Weatherly","orcid":"https://orcid.org/0000-0002-0509-4646","observed_orcids":["https://orcid.org/0000-0002-0509-4646"]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa M. Weatherly","raw_affiliation_strings":["Department of Molecular and Biomedical Sciences, University of Maine, Orono","Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Sciences, University of Maine, Orono","institution_ids":["https://openalex.org/I7947594"]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060764328","display_name":"Rachel H. Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel H. Kennedy","raw_affiliation_strings":["Department of Molecular and Biomedical Sciences, University of Maine, Orono","Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Sciences, University of Maine, Orono","institution_ids":["https://openalex.org/I7947594"]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110335416","display_name":"Juyoung Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juyoung Shim","raw_affiliation_strings":["Department of Molecular and Biomedical Sciences, University of Maine, Orono"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Sciences, University of Maine, Orono","institution_ids":["https://openalex.org/I7947594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012277599","display_name":"Julie A. Gosse","orcid":"https://orcid.org/0000-0002-2457-4039","observed_orcids":["https://orcid.org/0000-0002-2457-4039"]},"institutions":[{"id":"https://openalex.org/I7947594","display_name":"University of Maine","ror":"https://ror.org/01adr0w49","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I7947594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Gosse","raw_affiliation_strings":["Department of Molecular and Biomedical Sciences, University of Maine, Orono","Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Sciences, University of Maine, Orono","institution_ids":["https://openalex.org/I7947594"]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono","institution_ids":["https://openalex.org/I7947594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I7947594"],"apc_list":null,"apc_paid":null,"fwci":0.736,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72917619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":"81","first_page":"e50671","last_page":"e50671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/triclosan","display_name":"triclosan","score":0.9869999885559082},{"id":"https://openalex.org/keywords/beta-hexosaminidase","display_name":"beta-hexosaminidase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/microplate-assay","display_name":"microplate assay","score":0.7459999918937683},{"id":"https://openalex.org/keywords/fluorogenic-substrates","display_name":"fluorogenic substrates","score":0.7250000238418579},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.5130000114440918},{"id":"https://openalex.org/keywords/allergic-mediators","display_name":"allergic mediators","score":0.625},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.7599999904632568},{"id":"https://openalex.org/keywords/toxicant-screening","display_name":"toxicant screening","score":0.968999981880188},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.9016852378845215},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.8098849058151245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6491797566413879},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6327401399612427},{"id":"https://openalex.org/C2781289450","wikidata":"https://www.wikidata.org/wiki/Q408646","display_name":"Triclosan","level":2,"score":0.6236036419868469},{"id":"https://openalex.org/C2777361909","wikidata":"https://www.wikidata.org/wiki/Q419750","display_name":"Prostaglandin D2","level":3,"score":0.4393634796142578},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37496793270111084},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3692575693130493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3476017713546753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24737489223480225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18713021278381348},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.14466631412506104},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11671203374862671},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002021","descriptor_name":"Buffers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002021","descriptor_name":"Buffers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002021","descriptor_name":"Buffers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014260","descriptor_name":"Triclosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014260","descriptor_name":"Triclosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014260","descriptor_name":"Triclosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014260","descriptor_name":"Triclosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014260","descriptor_name":"Triclosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014260","descriptor_name":"Triclosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3791/50671","doi":"https://doi.org/10.3791/50671","is_oa":true,"landing_page_url":"https://doi.org/10.3791/50671","pdf_url":"https://www.jove.com/pdf/50671/a-microplate-assay-to-assess-chemical-effects-on-rbl-2h3-mast-cell","source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3597429","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3969050","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3969050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3969050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Vis Exp","raw_type":"Text"},{"id":"pmid:24300285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24300285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of visualized experiments : JoVE","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3791/50671","doi":"https://doi.org/10.3791/50671","is_oa":true,"landing_page_url":"https://doi.org/10.3791/50671","pdf_url":"https://www.jove.com/pdf/50671/a-microplate-assay-to-assess-chemical-effects-on-rbl-2h3-mast-cell","source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2430628023","display_name":null,"funder_award_id":"P20GM103423","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G249466046","display_name":null,"funder_award_id":"GM103423","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8441610034","display_name":"A Rising Tide:  Advancing Women and Leadership at the University of Maine","funder_award_id":"1008498","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000016900","display_name":null,"funder_award_id":"P20GM103423","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000345515","display_name":null,"funder_award_id":"GM103423","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306799","display_name":"Pharmaceutical Research and Manufacturers of America Foundation","ror":"https://ror.org/01z88k350"},{"id":"https://openalex.org/F4320312579","display_name":"University of Maine","ror":"https://ror.org/01adr0w49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2030242575.pdf","grobid_xml":"https://content.openalex.org/works/W2030242575.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W126099152","https://openalex.org/W160335679","https://openalex.org/W162009948","https://openalex.org/W1498098174","https://openalex.org/W1527504008","https://openalex.org/W1529522766","https://openalex.org/W1589627611","https://openalex.org/W1669810599","https://openalex.org/W1937163697","https://openalex.org/W1969681253","https://openalex.org/W1971277490","https://openalex.org/W1974337241","https://openalex.org/W1983652934","https://openalex.org/W1989613035","https://openalex.org/W1991324645","https://openalex.org/W1993633251","https://openalex.org/W2001595355","https://openalex.org/W2009338220","https://openalex.org/W2009638175","https://openalex.org/W2013095403","https://openalex.org/W2019879970","https://openalex.org/W2023503340","https://openalex.org/W2024054220","https://openalex.org/W2025538534","https://openalex.org/W2026430846","https://openalex.org/W2029531386","https://openalex.org/W2033369229","https://openalex.org/W2034144685","https://openalex.org/W2037766564","https://openalex.org/W2038882931","https://openalex.org/W2042305578","https://openalex.org/W2043781895","https://openalex.org/W2044165644","https://openalex.org/W2058306453","https://openalex.org/W2059707830","https://openalex.org/W2063660442","https://openalex.org/W2072560747","https://openalex.org/W2073244152","https://openalex.org/W2074748122","https://openalex.org/W2077481700","https://openalex.org/W2080735446","https://openalex.org/W2082549901","https://openalex.org/W2083513354","https://openalex.org/W2086257736","https://openalex.org/W2087424636","https://openalex.org/W2087992398","https://openalex.org/W2103201095","https://openalex.org/W2106317719","https://openalex.org/W2110335694","https://openalex.org/W2130438659","https://openalex.org/W2140152586","https://openalex.org/W2142853069","https://openalex.org/W2150357382","https://openalex.org/W2158916918","https://openalex.org/W2159320790","https://openalex.org/W2160818462","https://openalex.org/W2169911315","https://openalex.org/W2171595126","https://openalex.org/W2184211858","https://openalex.org/W2467165481"],"related_works":["https://openalex.org/W2038882931","https://openalex.org/W2171537217","https://openalex.org/W2762715944","https://openalex.org/W4388737014","https://openalex.org/W2899298262","https://openalex.org/W2467799233","https://openalex.org/W2008055040","https://openalex.org/W2901391784","https://openalex.org/W2360656192","https://openalex.org/W2356579691"],"abstract_inverted_index":{"Mast":[0,49,76],"cells":[1,65],"play":[2],"important":[3],"roles":[4],"in":[5,25,55,89,112,155,168],"allergic":[6,29,82,170,264],"disease":[7],"and":[8,38,80,98,139,141,159,224,226,260],"immune":[9],"defense":[10],"against":[11],"parasites.":[12],"Once":[13],"activated":[14],"(e.g.":[15],"by":[16,36,124],"an":[17,184,206,212],"allergen),":[18],"they":[19],"degranulate,":[20],"a":[21,67,105,113,148,165,248],"process":[22],"that":[23,116,152,198],"results":[24],"the":[26,58,81,135,174,187,242],"exocytosis":[27],"of":[28,32,60,71,137,189,211,250],"mediators.":[30],"Modulation":[31],"mast":[33,64,74,94,192,202,257],"cell":[34,50,77,193,203,258],"degranulation":[35,132],"drugs":[37,138],"toxicants":[39,140],"may":[40],"have":[41,129],"positive":[42],"or":[43],"adverse":[44],"effects":[45,255],"on":[46,191,256],"human":[47,72,169],"health.":[48],"function":[51],"has":[52,160,241],"been":[53,161],"dissected":[54],"detail":[56],"with":[57,91,104,222,247],"use":[59,144,210],"rat":[61],"basophilic":[62],"leukemia":[63],"(RBL-2H3),":[66],"widely":[68],"accepted":[69],"model":[70],"mucosal":[73],"cells(3-5).":[75],"granule":[78],"component":[79],"mediator":[83],"\u03b2-hexosaminidase,":[84],"which":[85],"is":[86,117,147,153,179,216,229],"released":[87],"linearly":[88],"tandem":[90],"histamine":[92],"from":[93],"cells(6),":[95],"can":[96],"easily":[97],"reliably":[99],"be":[100,164,245],"measured":[101],"through":[102],"reaction":[103],"fluorogenic":[106],"substrate,":[107],"yielding":[108],"measurable":[109],"fluorescence":[110],"intensity":[111],"microplate":[114],"assay":[115,133,185],"amenable":[118],"to":[119,163,208,244,252],"high-throughput":[120],"studies(1).":[121],"Originally":[122],"published":[123],"Naal":[125],"et":[126],"al.(1),":[127],"we":[128,182],"adapted":[130],"this":[131,177],"for":[134,176,186],"screening":[136],"demonstrate":[142,183],"its":[143],"here.":[145],"Triclosan":[146],"broad-spectrum":[149],"antibacterial":[150],"agent":[151],"present":[154],"many":[156],"consumer":[157],"products":[158],"found":[162],"therapeutic":[166],"aid":[167],"skin":[171],"disease(7-11),":[172],"although":[173],"mechanism":[175],"effect":[178,188],"unknown.":[180],"Here":[181],"triclosan":[190,199,215],"degranulation.":[194],"We":[195],"recently":[196],"showed":[197],"strongly":[200],"affects":[201],"function(2).":[204],"In":[205],"effort":[207],"avoid":[209],"organic":[213],"solvent,":[214],"dissolved":[217],"directly":[218],"into":[219],"aqueous":[220],"buffer":[221],"heat":[223],"stirring,":[225],"resultant":[227],"concentration":[228],"confirmed":[230],"using":[231],"UV-Vis":[232],"spectrophotometry":[233],"(using":[234],"\u03b5280":[235],"=":[236],"4,200":[237],"L/M/cm)(12).":[238],"This":[239],"protocol":[240],"potential":[243],"used":[246],"variety":[249],"chemicals":[251],"determine":[253],"their":[254,263],"degranulation,":[259],"more":[261],"broadly,":[262],"potential.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
