{"id":"https://openalex.org/W20302269","doi":null,"title":"The Cost-Effectiveness of Combination Treatment Consisting of Either Cetuximab or Panitumumab plus FOLFIRI versus Treatment with Bevacizumab plus FOLFIRI as First-Line Treatment for KRAS Wild-Type Metastatic Colorectal Cancer Patients in Ontario","display_name":"The Cost-Effectiveness of Combination Treatment Consisting of Either Cetuximab or Panitumumab plus FOLFIRI versus Treatment with Bevacizumab plus FOLFIRI as First-Line Treatment for KRAS Wild-Type Metastatic Colorectal Cancer Patients in Ontario","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W20302269","mag":"20302269"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-2241","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/927","pdf_url":"https://ir.lib.uwo.ca/etd/927","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.lib.uwo.ca/etd/927","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009449478","display_name":"Emmanuel M. Ewara","orcid":"https://orcid.org/0000-0001-5354-9329","observed_orcids":["https://orcid.org/0000-0001-5354-9329"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emmanuel M. Ewara","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5354-9329","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009449478"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6641,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.79522081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.11249999701976776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.800000011920929},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9340000152587891},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":1.0},{"id":"https://openalex.org/keywords/folfiri","display_name":"FOLFIRI","score":0.9240000247955322},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/kras-wild-type","display_name":"KRAS wild-type","score":0.9490000009536743},{"id":"https://openalex.org/keywords/markov-decision-process","display_name":"Markov decision process","score":0.6779999732971191},{"id":"https://openalex.org/keywords/incremental-cost-effectiveness-ratio","display_name":"incremental cost-effectiveness ratio","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C2776705615","wikidata":"https://www.wikidata.org/wiki/Q1389369","display_name":"FOLFIRI","level":5,"score":0.9409986138343811},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.8780876994132996},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.8680768013000488},{"id":"https://openalex.org/C2778332735","wikidata":"https://www.wikidata.org/wiki/Q417775","display_name":"Panitumumab","level":5,"score":0.8589173555374146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7318092584609985},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.655004620552063},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6207536458969116},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5882891416549683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5658679008483887},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.26889944076538086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2588271498680115},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.25407058000564575}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-2241","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/927","pdf_url":"https://ir.lib.uwo.ca/etd/927","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/32944","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/32944","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:20302269","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2241&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-2241","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/927","pdf_url":"https://ir.lib.uwo.ca/etd/927","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311055","display_name":"Cancer Care Ontario","ror":"https://ror.org/029n6xw55"},{"id":"https://openalex.org/F4320313712","display_name":"Institute for Clinical Evaluative Sciences","ror":"https://ror.org/05p6rhy72"},{"id":"https://openalex.org/F4320314607","display_name":"Government of Ontario","ror":"https://ror.org/015pzp858"},{"id":"https://openalex.org/F4320319966","display_name":"Ontario Ministry of Health and Long-Term Care","ror":"https://ror.org/00tjpb250"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W20302269.pdf","grobid_xml":"https://content.openalex.org/works/W20302269.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W25886346","https://openalex.org/W28937596","https://openalex.org/W83408045","https://openalex.org/W85469694","https://openalex.org/W90477195","https://openalex.org/W160431106","https://openalex.org/W1544851750","https://openalex.org/W1566902700","https://openalex.org/W1595046345","https://openalex.org/W1749379117","https://openalex.org/W1967778685","https://openalex.org/W1972513239","https://openalex.org/W1973005031","https://openalex.org/W1974783008","https://openalex.org/W1975747597","https://openalex.org/W1975873291","https://openalex.org/W1979044834","https://openalex.org/W1980623960","https://openalex.org/W1983311486","https://openalex.org/W1988231446","https://openalex.org/W1993599317","https://openalex.org/W1995732705","https://openalex.org/W1995934753","https://openalex.org/W1996198481","https://openalex.org/W1999250974","https://openalex.org/W2001258296","https://openalex.org/W2002062579","https://openalex.org/W2007894352","https://openalex.org/W2011492006","https://openalex.org/W2012006000","https://openalex.org/W2028045370","https://openalex.org/W2036926586","https://openalex.org/W2043951092","https://openalex.org/W2043961314","https://openalex.org/W2045888711","https://openalex.org/W2064047613","https://openalex.org/W2064363036","https://openalex.org/W2065456272","https://openalex.org/W2066715163","https://openalex.org/W2069703793","https://openalex.org/W2071471252","https://openalex.org/W2072004536","https://openalex.org/W2072508272","https://openalex.org/W2073881958","https://openalex.org/W2083196121","https://openalex.org/W2083541647","https://openalex.org/W2083743528","https://openalex.org/W2084655166","https://openalex.org/W2088563616","https://openalex.org/W2091590276","https://openalex.org/W2092382295","https://openalex.org/W2095201384","https://openalex.org/W2097121246","https://openalex.org/W2098354753","https://openalex.org/W2101711321","https://openalex.org/W2101815035","https://openalex.org/W2104580737","https://openalex.org/W2106152781","https://openalex.org/W2106787323","https://openalex.org/W2110624670","https://openalex.org/W2112727687","https://openalex.org/W2112911107","https://openalex.org/W2113044973","https://openalex.org/W2115790682","https://openalex.org/W2120490763","https://openalex.org/W2120552000","https://openalex.org/W2122618533","https://openalex.org/W2122664355","https://openalex.org/W2123946290","https://openalex.org/W2125447919","https://openalex.org/W2131183275","https://openalex.org/W2132545630","https://openalex.org/W2133399075","https://openalex.org/W2134142320","https://openalex.org/W2134920919","https://openalex.org/W2139168548","https://openalex.org/W2143743735","https://openalex.org/W2144425748","https://openalex.org/W2145070131","https://openalex.org/W2145229939","https://openalex.org/W2147718573","https://openalex.org/W2155311724","https://openalex.org/W2159303174","https://openalex.org/W2161516303","https://openalex.org/W2164654252","https://openalex.org/W2164837623","https://openalex.org/W2165566097","https://openalex.org/W2165741055","https://openalex.org/W2168246508","https://openalex.org/W2168479321","https://openalex.org/W2170332580","https://openalex.org/W2171470036","https://openalex.org/W2171790106","https://openalex.org/W2187276276","https://openalex.org/W2318393109","https://openalex.org/W2567238124"],"related_works":["https://openalex.org/W2098227097","https://openalex.org/W2141479869","https://openalex.org/W2397281125","https://openalex.org/W2999500669","https://openalex.org/W2338945910","https://openalex.org/W2567238124","https://openalex.org/W2544673594","https://openalex.org/W2045916016","https://openalex.org/W3000519369","https://openalex.org/W2095953274"],"abstract_inverted_index":{"I":[0,30],"conducted":[1],"a":[2,32],"cost-effectiveness":[3],"analysis":[4],"of":[5,25,44,61,75,97,101,117,126],"combination":[6],"cetuximbab":[7],"or":[8],"panitumumab":[9],"plus":[10,77,112],"FOLFIRI":[11,78,113],"as":[12],"first-line":[13,98,115],"treatment":[14,46,73,84,116,134],"for":[15,114,136],"patients":[16,118],"with":[17,119],"metastatic":[18,120],"colorectal":[19,121],"cancer":[20],"(MCRC)":[21],"from":[22,55,64],"the":[23,26,39,59,69,95,123,131],"perspective":[24],"Ontario":[27,62,129],"healthcare":[28],"payer.":[29],"developed":[31],"Markov":[33],"decision":[34],"analytical":[35],"model":[36,49],"to":[37,81,91,94],"simulate":[38],"lifetime":[40],"costs":[41],"and":[42,63,103,105],"benefits":[43],"each":[45],"option.":[47],"The":[48,86],"was":[50,79],"parameterized":[51],"using":[52],"data":[53],"collected":[54],"administrative":[56],"databases":[57],"in":[58,128],"province":[60],"published":[65],"clinical":[66],"trials.":[67],"In":[68,109],"base":[70],"case":[71],"scenario,":[72],"consisting":[74],"bevacizumab":[76,102,111],"found":[80,90],"dominate":[82],"other":[83],"options.":[85],"ICER":[87],"values":[88],"were":[89],"be":[92],"sensitive":[93],"efficacy":[96],"treatment,":[99],"cost":[100],"cetuximab,":[104],"health":[106],"utility":[107],"values.":[108],"conclusion":[110],"cancer,":[122],"current":[124],"standard":[125],"care":[127],"is":[130],"most":[132],"cost-effective":[133],"option":[135],"these":[137],"patients.":[138]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}