{"id":"https://openalex.org/W2030224418","doi":"https://doi.org/10.1080/19768354.2014.992953","title":"Hypocholesterolemic effects ofCurcuma longaL. withNelumbo nuciferaleaf in anin vitromodel and a high cholesterol diet-induced hypercholesterolemic mouse model","display_name":"Hypocholesterolemic effects ofCurcuma longaL. withNelumbo nuciferaleaf in anin vitromodel and a high cholesterol diet-induced hypercholesterolemic mouse model","publication_year":2015,"publication_date":"2015-02-03","ids":{"openalex":"https://openalex.org/W2030224418","doi":"https://doi.org/10.1080/19768354.2014.992953","mag":"2030224418"},"language":"en","primary_location":{"id":"doi:10.1080/19768354.2014.992953","doi":"https://doi.org/10.1080/19768354.2014.992953","is_oa":false,"landing_page_url":"https://doi.org/10.1080/19768354.2014.992953","pdf_url":null,"source":{"id":"https://openalex.org/S90343918","display_name":"Animal Cells and Systems","issn_l":"1976-8354","issn":["1976-8354","2151-2485"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Cells and Systems","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004102285","display_name":"Myung\u2010A Jung","orcid":"https://orcid.org/0000-0003-3132-7308","observed_orcids":["https://orcid.org/0000-0003-3132-7308"]},"institutions":[{"id":"https://openalex.org/I4210128668","display_name":"Jeonnam Bioindustry Foundation","ror":"https://ror.org/03pj17v68","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128668"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myung-A Jung","raw_affiliation_strings":["Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea","institution_ids":["https://openalex.org/I4210128668"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sun Young Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128668","display_name":"Jeonnam Bioindustry Foundation","ror":"https://ror.org/03pj17v68","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128668"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Young Lee","raw_affiliation_strings":["Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea","institution_ids":["https://openalex.org/I4210128668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077201910","display_name":"Seul Hee Han","orcid":"https://orcid.org/0000-0002-8425-0124","observed_orcids":["https://orcid.org/0000-0002-8425-0124"]},"institutions":[{"id":"https://openalex.org/I4210128668","display_name":"Jeonnam Bioindustry Foundation","ror":"https://ror.org/03pj17v68","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128668"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seul Hee Han","raw_affiliation_strings":["Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea","institution_ids":["https://openalex.org/I4210128668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025444464","display_name":"Ji\u2010Ae Hong","orcid":"https://orcid.org/0000-0003-1323-1505","observed_orcids":["https://orcid.org/0000-0003-1323-1505"]},"institutions":[{"id":"https://openalex.org/I4210128668","display_name":"Jeonnam Bioindustry Foundation","ror":"https://ror.org/03pj17v68","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128668"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiae Hong","raw_affiliation_strings":["Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea","institution_ids":["https://openalex.org/I4210128668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007333924","display_name":"Ju-Ryun Na","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128668","display_name":"Jeonnam Bioindustry Foundation","ror":"https://ror.org/03pj17v68","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128668"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju-Ryun Na","raw_affiliation_strings":["Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea","institution_ids":["https://openalex.org/I4210128668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109142162","display_name":"Joon Yeol Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joon Yeol Lee","raw_affiliation_strings":["Korea INS Pharm Research Institute, Jeollanamdo519-882, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea INS Pharm Research Institute, Jeollanamdo519-882, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100704613","display_name":"Yong\u2010Jae Kim","orcid":"https://orcid.org/0000-0002-8193-1469","observed_orcids":["https://orcid.org/0000-0002-8193-1469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongjae Kim","raw_affiliation_strings":["Korea INS Pharm Research Institute, Jeollanamdo519-882, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea INS Pharm Research Institute, Jeollanamdo519-882, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057156940","display_name":"Sunoh Kim","orcid":"https://orcid.org/0000-0003-0407-6339","observed_orcids":["https://orcid.org/0000-0003-0407-6339"]},"institutions":[{"id":"https://openalex.org/I4210128668","display_name":"Jeonnam Bioindustry Foundation","ror":"https://ror.org/03pj17v68","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128668"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sunoh Kim","raw_affiliation_strings":["Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR), Jeollanamdo529-851, Korea","institution_ids":["https://openalex.org/I4210128668"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057156940"],"corresponding_institution_ids":["https://openalex.org/I4210128668"],"apc_list":{"value":1190,"currency":"GBP","value_usd":1459},"apc_paid":null,"fwci":0.2244,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.46799163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"19","issue":"2","first_page":"133","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/turmeric","display_name":"turmeric","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nelumbo-nucifera","display_name":"Nelumbo nucifera","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cholesterol-lowering-effect","display_name":"cholesterol-lowering effect","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.6859999895095825},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/atherogenic-index","display_name":"atherogenic index","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.6510000228881836},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6060000061988831},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.5180000066757202},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.4569999873638153},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6812579035758972},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5737940669059753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5646311640739441},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.5079026818275452},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.4704764485359192},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.438425213098526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43095824122428894},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4253816604614258},{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.4245702028274536},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.42359262704849243},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.42244693636894226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4159461259841919},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4108262062072754},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40984874963760376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24755799770355225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2231372892856598},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1414071023464203},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0612466037273407},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/19768354.2014.992953","doi":"https://doi.org/10.1080/19768354.2014.992953","is_oa":false,"landing_page_url":"https://doi.org/10.1080/19768354.2014.992953","pdf_url":null,"source":{"id":"https://openalex.org/S90343918","display_name":"Animal Cells and Systems","issn_l":"1976-8354","issn":["1976-8354","2151-2485"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","kci-registered","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Cells and Systems","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322064","display_name":"Korea Institute for Advancement of Technology","ror":"https://ror.org/015w1qa96"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W34120688","https://openalex.org/W41922719","https://openalex.org/W78741705","https://openalex.org/W262841333","https://openalex.org/W1565266604","https://openalex.org/W1653501894","https://openalex.org/W1978174486","https://openalex.org/W1994051836","https://openalex.org/W2006311158","https://openalex.org/W2006911110","https://openalex.org/W2016617561","https://openalex.org/W2018652620","https://openalex.org/W2026042453","https://openalex.org/W2038771381","https://openalex.org/W2040701698","https://openalex.org/W2042769296","https://openalex.org/W2049054704","https://openalex.org/W2055634483","https://openalex.org/W2057234788","https://openalex.org/W2061686373","https://openalex.org/W2064026168","https://openalex.org/W2079378050","https://openalex.org/W2085309008","https://openalex.org/W2093751113","https://openalex.org/W2107722417","https://openalex.org/W2116404316","https://openalex.org/W2119634573","https://openalex.org/W2126553921","https://openalex.org/W2141543169","https://openalex.org/W2153391743","https://openalex.org/W2168526937","https://openalex.org/W2404883728","https://openalex.org/W2950083701","https://openalex.org/W4211051145"],"related_works":["https://openalex.org/W4214720895","https://openalex.org/W132176917","https://openalex.org/W2164937977","https://openalex.org/W4413852868","https://openalex.org/W4384134255","https://openalex.org/W2737371190","https://openalex.org/W4409907659","https://openalex.org/W2944883871","https://openalex.org/W2949676383","https://openalex.org/W2316512322"],"abstract_inverted_index":{"Hypercholesterolemia":[0],"is":[1],"one":[2],"of":[3,26,29,36,67,84,91,113,119,133,146,149,217,232,238],"the":[4,24,88,95,144,147,188,215,230,236,243],"well-established":[5],"risk":[6,172],"factors":[7],"for":[8,127],"cardiovascular":[9],"mortality":[10],"and":[11,33,41,51,70,76,87,136,182,191,200,225,227],"morbidity":[12],"in":[13,48,49,52,57,58,99,143],"coronary":[14],"heart":[15],"disease.":[16],"The":[17,80,98,130],"present":[18],"study":[19,240],"was":[20,103],"designed":[21],"to":[22],"investigate":[23],"effects":[25,248],"different":[27],"types":[28],"extracts":[30,66,193],"(aqueous,":[31],"20%-,":[32],"80%":[34],"ethanol)":[35],"Nelumbo":[37],"nucifera":[38],"leaf":[39],"(NL)":[40],"Curcuma":[42],"Longa":[43],"L.":[44],"(CL)":[45],"on":[46],"hypercholesterolemia":[47],"vitro":[50,59],"vivo":[53,100],"models.":[54],"Our":[55],"results":[56,237],"experiments":[60],"showed":[61,94,208],"that":[62,242,249],"treatment":[63],"with":[64,110,121],"various":[65],"both":[68],"NL":[69,85],"CL":[71,92],"dose-dependently":[72],"inhibited":[73],"lipid":[74,158,251],"accumulation":[75],"total":[77,151],"cholesterol":[78,107,152,198,202],"content.":[79],"20%":[81],"ethanol":[82],"extract":[83,90],"(NL20E)":[86],"aqueous":[89],"(CLW)":[93],"highest":[96],"activity.":[97,205],"experimental":[101],"group":[102],"fed":[104],"a":[105,117,209],"high":[106],"diet":[108],"(HCD)":[109],"oral":[111,131],"administration":[112,132],"NL20E,":[114,134,189],"CLW,":[115,135,190],"or":[116,139],"mixture":[118],"NL20E":[120],"CLW":[122],"(NC;":[123],"mixed":[124],"equal":[125],"ratio)":[126],"8":[128],"weeks.":[129],"NC":[137,192,207,244],"(100":[138],"300":[140],"mg/kg/day)":[141],"resulted":[142],"suppression":[145],"levels":[148,199,216,231],"serum":[150],"(TC),":[153],"low-density":[154],"lipoprotein":[155,196],"(LDL)-cholesterol,":[156],"liver":[157],"level,":[159],"glutamic":[160,164],"oxaloacetic":[161],"transaminase":[162,166],"(GOT),":[163],"pyruvic":[165],"(GPT),":[167],"atherogenic":[168],"index":[169],"(AI),":[170],"cardiac":[171],"factor":[173],"(CRF),":[174],"cholesteryl":[175],"ester":[176],"transfer":[177],"protein":[178],"(CETP),":[179],"HMG-CoA":[180,223],"reductase,":[181,224],"thiobarbituric":[183],"acid-reactive":[184],"substances":[185],"(TBARS).":[186],"Similarly,":[187],"elevated":[194],"high-density":[195],"(HDL)":[197],"lecithin":[201],"acyltransferase":[203],"(LCAT)":[204],"Furthermore,":[206],"remarkable":[210],"hypocholesterolemic":[211,247],"effect":[212],"by":[213,228],"decreasing":[214],"hepatic":[218],"TC,":[219],"AI,":[220],"LDL":[221],"cholesterol,":[222],"CRE":[226],"increasing":[229],"HDL":[233],"cholesterol.":[234],"Thus,":[235],"this":[239],"indicate":[241],"has":[245],"combined":[246],"block":[250],"accumulation,":[252],"thus":[253],"preventing":[254],"hypercholesterolemia.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
