{"id":"https://openalex.org/W2030159640","doi":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<633::aid-cncr44>3.0.co;2-x","title":"Activity of gemcitabine in patients with advanced pancreatic carcinoma: A review","display_name":"Activity of gemcitabine in patients with advanced pancreatic carcinoma: A review","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2030159640","doi":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<633::aid-cncr44>3.0.co;2-x","mag":"2030159640","pmid":"https://pubmed.ncbi.nlm.nih.gov/8681302"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0142(19960801)78:3<633::aid-cncr44>3.0.co;2-x","doi":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<633::aid-cncr44>3.0.co;2-x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<633::aid-cncr44>3.0.co;2-x","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Malcolm Moore","raw_affiliation_strings":["Department of Medicine, Princess Margaret Hospital, University of Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Princess Margaret Hospital, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110863459"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":5.1473,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.96052697,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"78","issue":"3","first_page":"633","last_page":"638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":1.0},{"id":"https://openalex.org/keywords/advanced-pancreatic-cancer","display_name":"advanced pancreatic cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/analgesic-use","display_name":"analgesic use","score":0.996999979019165},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5329999923706055},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.9697795510292053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9301998615264893},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8101251721382141},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5990034937858582},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5879738330841064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5713992714881897},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.5267293453216553},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.510200023651123},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5040003657341003},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4578891694545746},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44066929817199707},{"id":"https://openalex.org/C3020076753","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic carcinoma","level":4,"score":0.43414169549942017},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.36386430263519287}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-0142(19960801)78:3<633::aid-cncr44>3.0.co;2-x","doi":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<633::aid-cncr44>3.0.co;2-x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<633::aid-cncr44>3.0.co;2-x","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:8681302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8681302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1527742565","https://openalex.org/W1968837173","https://openalex.org/W1971150016","https://openalex.org/W1984173326","https://openalex.org/W1985609148","https://openalex.org/W2024210946","https://openalex.org/W2047256093","https://openalex.org/W2049969048","https://openalex.org/W2058084282","https://openalex.org/W2059125479","https://openalex.org/W2061271254","https://openalex.org/W2084562398","https://openalex.org/W2097166160","https://openalex.org/W2118512375","https://openalex.org/W4233130113","https://openalex.org/W4244373493"],"related_works":["https://openalex.org/W2418564374","https://openalex.org/W2417351619","https://openalex.org/W2329900300","https://openalex.org/W4389802987","https://openalex.org/W2011195685","https://openalex.org/W2050272257","https://openalex.org/W2036449594","https://openalex.org/W2589673404","https://openalex.org/W2415381472","https://openalex.org/W2387104737"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,51],"early":[2],"phase":[3],"II":[4],"trials":[5,92],"in":[6,17,27,87,99,128,162],"advanced":[7,102,129],"pancreatic":[8,103,130,166],"cancer,":[9],"gemcitabine":[10,22,113,161],"demonstrated":[11],"modest":[12],"antitumor":[13],"activity.":[14],"The":[15,106,132],"investigators":[16],"these":[18,109],"studies":[19,110,150],"reported":[20],"that":[21,66,112],"should":[23],"be":[24,82,146,152],"studied":[25],"further":[26],"view":[28],"of":[29,34,40,42,61,108,134,160,165],"the":[30,38,43,46,115,158,163],"degree":[31,133],"and":[32,45,74,84,125],"frequency":[33],"symptomatic":[35,56],"improvement":[36,135],"observed,":[37],"durability":[39],"some":[41],"remissions,":[44],"favorable":[47],"toxicity":[48],"profile.":[49],"METHODS:":[50],"order":[52],"to":[53,81,145,154],"quantify":[54],"such":[55],"improvement,":[57],"a":[58],"rigorous":[59],"endpoint":[60],"Clinical":[62],"Benefit":[63],"was":[64],"developed":[65],"incorporated":[67],"measures":[68],"including":[69],"pain":[70],"intensity,":[71],"analgesic":[72],"consumption":[73],"performance":[75],"status,":[76],"which":[77,139],"have":[78,93],"been":[79,94],"shown":[80],"reliable":[83],"valid":[85],"endpoints":[86],"other":[88],"studies.":[89],"RESULTS:":[90],"Two":[91],"conducted":[95],"using":[96],"this":[97],"methodology":[98],"patients":[100,140],"with":[101,119,141],"carcinoma.":[104],"CONCLUSIONS:":[105],"results":[107],"suggest":[111],"is":[114,137],"first":[116],"cytotoxic":[117],"agent":[118],"any":[120],"meaningful":[121],"impact":[122],"on":[123],"survival":[124],"disease-related":[126],"symptoms":[127],"adenocarcinoma.":[131],"seen":[136],"one":[138],"cancer":[142],"often":[143],"consider":[144],"most":[147],"important.":[148],"Further":[149],"will":[151],"required":[153],"define":[155],"more":[156],"fully":[157],"role":[159],"treatment":[164],"cancer.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}