{"id":"https://openalex.org/W2030140844","doi":"https://doi.org/10.1172/jci109818","title":"Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.","display_name":"Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.","publication_year":1980,"publication_date":"1980-06-01","ids":{"openalex":"https://openalex.org/W2030140844","doi":"https://doi.org/10.1172/jci109818","mag":"2030140844","pmid":"https://pubmed.ncbi.nlm.nih.gov/6251113","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/371492"},"language":"en","primary_location":{"id":"doi:10.1172/jci109818","doi":"https://doi.org/10.1172/jci109818","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109818","pdf_url":"http://www.jci.org/articles/view/109818/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/109818/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083674919","display_name":"Robert V. Farese","orcid":"https://orcid.org/0000-0001-8103-2239","observed_orcids":["https://orcid.org/0000-0001-8103-2239"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R V Farese","raw_affiliation_strings":["Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051260872","display_name":"P Bidot-L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Bidot-L\u00f3pez","raw_affiliation_strings":["Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Sabir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Sabir","raw_affiliation_strings":["Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J S Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Smith","raw_affiliation_strings":["Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057068232","display_name":"B Schinbeckler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Schinbeckler","raw_affiliation_strings":["Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":null,"display_name":"R Larson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Larson","raw_affiliation_strings":["Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Administrationt Hospital atnd Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":10.5711,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.98875306,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"6","first_page":"1523","last_page":"1526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":1.0},{"id":"https://openalex.org/keywords/polyphosphoinositides","display_name":"polyphosphoinositides","score":0.9909999966621399},{"id":"https://openalex.org/keywords/diphosphoinositide","display_name":"diphosphoinositide","score":0.9290000200271606},{"id":"https://openalex.org/keywords/triphosphoinositide","display_name":"triphosphoinositide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-cortex","display_name":"renal cortex","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.875},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/phosphaturia","display_name":"phosphaturia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.9713882207870483},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7434877157211304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7294679880142212},{"id":"https://openalex.org/C2778577996","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Renal cortex","level":3,"score":0.6815847754478455},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6495203971862793},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6385771036148071},{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.6035051345825195},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5606708526611328},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.5362057089805603},{"id":"https://openalex.org/C2910561336","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Kidney cortex","level":3,"score":0.5070834159851074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4343872666358948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3487367630004883},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.2636338472366333},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.20733770728111267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20639339089393616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1411171853542328},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci109818","doi":"https://doi.org/10.1172/jci109818","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109818","pdf_url":"http://www.jci.org/articles/view/109818/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:371492","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/371492","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:6251113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6251113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci109818","doi":"https://doi.org/10.1172/jci109818","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109818","pdf_url":"http://www.jci.org/articles/view/109818/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2030140844.pdf","grobid_xml":"https://content.openalex.org/works/W2030140844.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W47860036","https://openalex.org/W220668945","https://openalex.org/W1451410237","https://openalex.org/W1492086189","https://openalex.org/W1536730092","https://openalex.org/W1919997761","https://openalex.org/W1977650403","https://openalex.org/W2006555142","https://openalex.org/W2009153723","https://openalex.org/W2014779592","https://openalex.org/W2017861842","https://openalex.org/W2022909845","https://openalex.org/W2026608524","https://openalex.org/W2027032504","https://openalex.org/W2044707412","https://openalex.org/W2057371592","https://openalex.org/W2065287603","https://openalex.org/W2068712350","https://openalex.org/W2072099683","https://openalex.org/W2086561804","https://openalex.org/W2138017775","https://openalex.org/W2138859133","https://openalex.org/W2153435210","https://openalex.org/W2497343770","https://openalex.org/W4298038538","https://openalex.org/W6843650750"],"related_works":["https://openalex.org/W2058357166","https://openalex.org/W2079346703","https://openalex.org/W1492086189","https://openalex.org/W2025908951","https://openalex.org/W2031236213","https://openalex.org/W2472233616","https://openalex.org/W2088363272","https://openalex.org/W2129235567","https://openalex.org/W1551058913","https://openalex.org/W2185200034"],"abstract_inverted_index":{"Parathyroid":[0],"hormone(PTH)":[1],"rapidly":[2],"increases":[3],"the":[4,35],"concentrations":[5],"of":[6,19,45],"diphosphoinositide":[7],"and":[8,30,38],"triphosphoinositide":[9],"in":[10,34],"rabbit":[11],"kidney":[12],"cortex.":[13],"Cycloheximide":[14],"pretreatment":[15],"abolishes":[16],"these":[17],"effects":[18,44],"PTH.":[20],"These":[21],"findings":[22],"are":[23],"similar":[24],"to":[25],"those":[26],"reported":[27],"for":[28],"adrenocorticotropin":[29],"cyclic":[31],"AMP":[32],"action":[33],"adrenal":[36],"cortex,":[37],"suggest":[39],"a":[40],"common":[41],"mechanism.":[42],"Cycloheximide-sensitive":[43],"PTH,":[46],"e.g.,":[47],"phosphaturia,":[48],"may":[49],"require":[50],"polyphosphoinositides":[51],"and/or":[52],"other":[53],"phospholipids.":[54]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
