{"id":"https://openalex.org/W2030047701","doi":"https://doi.org/10.1074/jbc.m102641200","title":"Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex","display_name":"Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2030047701","doi":"https://doi.org/10.1074/jbc.m102641200","mag":"2030047701","pmid":"https://pubmed.ncbi.nlm.nih.gov/11375397"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m102641200","doi":"https://doi.org/10.1074/jbc.m102641200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m102641200","pdf_url":"http://www.jbc.org/article/S0021925820899037/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820899037/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088475222","display_name":"Seth A. Ettenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth A. Ettenberg","raw_affiliation_strings":["Genetics Department of the Medicine Branch and the Laboratory of Immune Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889, USA","Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889","Molecular and Cell Biology Program, Uniform Services University of the Health Sciences, Bethesda, Maryland 20889, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Department of the Medicine Branch and the Laboratory of Immune Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Molecular and Cell Biology Program, Uniform Services University of the Health Sciences, Bethesda, Maryland 20889, and the","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010996217","display_name":"Alessandra Magnifico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandra Magnifico","raw_affiliation_strings":["Laboratory of Immune Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immune Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889, the","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052955113","display_name":"Mauricio A. Cuello","orcid":"https://orcid.org/0000-0003-2812-0015","observed_orcids":["https://orcid.org/0000-0003-2812-0015"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mauricio Cuello","raw_affiliation_strings":["Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109880700","display_name":"Marion M. Nau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marion M. Nau","raw_affiliation_strings":["Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054727385","display_name":"Yaffa Rubinstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaffa R. Rubinstein","raw_affiliation_strings":["Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038055187","display_name":"Yosef Yarden","orcid":"https://orcid.org/0000-0003-4168-7884","observed_orcids":["https://orcid.org/0000-0003-4168-7884","https://orcid.org/0000-0001-8578-0250"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yosef Yarden","raw_affiliation_strings":["Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083498586","display_name":"Allan M. Weissman","orcid":"https://orcid.org/0000-0002-7865-7702","observed_orcids":["https://orcid.org/0000-0002-7865-7702"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan M. Weissman","raw_affiliation_strings":["Laboratory of Immune Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immune Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889, the","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088511878","display_name":"Stan Lipkowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stan Lipkowitz","raw_affiliation_strings":["Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889","Molecular and Cell Biology Program, Uniform Services University of the Health Sciences, Bethesda, Maryland 20889, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Department of the Medicine Branch and the Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20889","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Molecular and Cell Biology Program, Uniform Services University of the Health Sciences, Bethesda, Maryland 20889, and the","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5088511878"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I148314036","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.0039,"has_fulltext":true,"cited_by_count":163,"citation_normalized_percentile":{"value":0.96342854,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"276","issue":"29","first_page":"27677","last_page":"27684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cbl-b","display_name":"Cbl-b","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/receptor-degradation","display_name":"receptor degradation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ring-finger-domain","display_name":"RING domain","score":0.8460000157356262},{"id":"https://openalex.org/keywords/grb2","display_name":"Grb2","score":0.828000009059906},{"id":"https://openalex.org/keywords/shc","display_name":"Shc","score":0.9950000047683716},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.7139999866485596},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.7459442019462585},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6680982708930969},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6544893980026245},{"id":"https://openalex.org/C177917778","wikidata":"https://www.wikidata.org/wiki/Q14905188","display_name":"GRB2","level":4,"score":0.6540719866752625},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6386440396308899},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5621598362922668},{"id":"https://openalex.org/C115456853","wikidata":"https://www.wikidata.org/wiki/Q17917132","display_name":"ERBB3","level":4,"score":0.5274156332015991},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.5252363681793213},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.480241596698761},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.45170485973358154},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.450570672750473},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.4259141683578491},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.41402193903923035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4024730920791626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39486274123191833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35195422172546387},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3491566479206085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050721","descriptor_name":"Proto-Oncogene Proteins c-cbl","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m102641200","doi":"https://doi.org/10.1074/jbc.m102641200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m102641200","pdf_url":"http://www.jbc.org/article/S0021925820899037/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11375397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11375397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m102641200","doi":"https://doi.org/10.1074/jbc.m102641200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m102641200","pdf_url":"http://www.jbc.org/article/S0021925820899037/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2030047701.pdf","grobid_xml":"https://content.openalex.org/works/W2030047701.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W32367602","https://openalex.org/W93114066","https://openalex.org/W1513014113","https://openalex.org/W1596079370","https://openalex.org/W1605218758","https://openalex.org/W1624856187","https://openalex.org/W1780544763","https://openalex.org/W1979153707","https://openalex.org/W1986627314","https://openalex.org/W1989970319","https://openalex.org/W1990259051","https://openalex.org/W2004311983","https://openalex.org/W2004759810","https://openalex.org/W2007249806","https://openalex.org/W2007962912","https://openalex.org/W2008063892","https://openalex.org/W2012507368","https://openalex.org/W2015291446","https://openalex.org/W2017824021","https://openalex.org/W2022376508","https://openalex.org/W2027533965","https://openalex.org/W2029849554","https://openalex.org/W2029962841","https://openalex.org/W2032329087","https://openalex.org/W2034786275","https://openalex.org/W2040196391","https://openalex.org/W2042116027","https://openalex.org/W2043141000","https://openalex.org/W2054160631","https://openalex.org/W2055324119","https://openalex.org/W2056530510","https://openalex.org/W2058216121","https://openalex.org/W2058758697","https://openalex.org/W2066284211","https://openalex.org/W2067415612","https://openalex.org/W2068451954","https://openalex.org/W2073936529","https://openalex.org/W2074056249","https://openalex.org/W2077017636","https://openalex.org/W2078369440","https://openalex.org/W2079539653","https://openalex.org/W2082979850","https://openalex.org/W2089593257","https://openalex.org/W2093646218","https://openalex.org/W2095467264","https://openalex.org/W2105442098","https://openalex.org/W2108366666","https://openalex.org/W2109232632","https://openalex.org/W2116023341","https://openalex.org/W2125919362","https://openalex.org/W2126582177","https://openalex.org/W2131151657","https://openalex.org/W2164188238","https://openalex.org/W2166987747","https://openalex.org/W2168379132","https://openalex.org/W2169290377","https://openalex.org/W2170170334","https://openalex.org/W2171164575","https://openalex.org/W2313128584","https://openalex.org/W2402326496"],"related_works":["https://openalex.org/W2008063892","https://openalex.org/W2726541268","https://openalex.org/W2062209120","https://openalex.org/W3174037948","https://openalex.org/W4241668367","https://openalex.org/W140648242","https://openalex.org/W2074877259","https://openalex.org/W2157256314","https://openalex.org/W2004759810","https://openalex.org/W4253519051"],"abstract_inverted_index":{"Cbl":[0],"proteins":[1,130],"function":[2,104],"as":[3],"ubiquitin":[4,101],"protein":[5,55,70,102,115],"ligases":[6],"for":[7],"the":[8,32,53,57,65,68,81,100,113,121,132],"activated":[9,58],"epidermal":[10],"growth":[11,35],"factor":[12,36],"receptor":[13,60],"and,":[14],"thus,":[15],"negatively":[16],"regulate":[17],"its":[18,118],"activity.":[19],"Here":[20],"we":[21],"show":[22],"that":[23,99,124],"Cbl-b":[24,38,54,69,106,114,125],"is":[25,71,107],"ubiquitinated":[26],"and":[27,44,49,67,75,86],"degraded":[28,90],"upon":[29],"activation":[30],"of":[31,52,63,80,105,112,128],"receptor.":[33],"Epidermal":[34],"(EGF)-induced":[37],"degradation":[39,111,127],"requires":[40,50],"intact":[41],"RING":[42],"finger":[43],"tyrosine":[45],"kinase":[46],"binding":[47,51],"domains":[48],"to":[56],"EGF":[59],"(EGFR).":[61],"Degradation":[62],"both":[64],"EGFR":[66],"blocked":[72],"by":[73,109],"lysosomal":[74],"proteasomal":[76],"inhibitors.":[77],"Other":[78],"components":[79],"EGFR-signaling":[82,133],"complex":[83],"(i.e.":[84],"Grb2":[85],"Shc)":[87],"are":[88],"also":[89],"in":[91,131],"an":[92],"EGF-induced":[93],"Cbl-b-dependent":[94],"fashion.":[95],"Our":[96],"results":[97],"suggest":[98],"ligase":[103],"regulated":[108],"coordinated":[110],"along":[116],"with":[117],"substrate.":[119],"Furthermore,":[120],"data":[122],"demonstrate":[123],"mediates":[126],"multiple":[129],"complex.":[134]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}