{"id":"https://openalex.org/W2030000366","doi":"https://doi.org/10.1210/jcem-55-2-384","title":"CORTICOTROPIN-RELEASING FACTOR-LIKE ACTIVITY IN HUMAN PLACENTAL EXTRACTS","display_name":"CORTICOTROPIN-RELEASING FACTOR-LIKE ACTIVITY IN HUMAN PLACENTAL EXTRACTS","publication_year":1982,"publication_date":"1982-08-01","ids":{"openalex":"https://openalex.org/W2030000366","doi":"https://doi.org/10.1210/jcem-55-2-384","mag":"2030000366","pmid":"https://pubmed.ncbi.nlm.nih.gov/6282924"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-55-2-384","doi":"https://doi.org/10.1210/jcem-55-2-384","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-55-2-384","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2030000366"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111645416","display_name":"Tamotsu Shibasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamotsu Shibasaki","raw_affiliation_strings":["Department of Medicine, Tokyo Women's Medical College 10 Kawada-cho, Shinjuku-ku, Tokyo 162 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women's Medical College 10 Kawada-cho, Shinjuku-ku, Tokyo 162 Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089598411","display_name":"E Odagiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Emi Odagiri","raw_affiliation_strings":["Department of Medicine, Tokyo Women's Medical College 10 Kawada-cho, Shinjuku-ku, Tokyo 162 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women's Medical College 10 Kawada-cho, Shinjuku-ku, Tokyo 162 Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033893823","display_name":"KAZUO SHIZUME","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Shizume","raw_affiliation_strings":["Department of Medicine, Tokyo Women's Medical College 10 Kawada-cho, Shinjuku-ku, Tokyo 162 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Women's Medical College 10 Kawada-cho, Shinjuku-ku, Tokyo 162 Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077195123","display_name":"NICHOLAS C. LING","orcid":"https://orcid.org/0000-0002-0853-7035","observed_orcids":["https://orcid.org/0000-0002-0853-7035"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Ling","raw_affiliation_strings":["Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk Institute for Biological Studies, La Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.9144,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.64759397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"55","issue":"2","first_page":"384","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.16019999980926514,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.058800000697374344,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.8899999856948853},{"id":"https://openalex.org/keywords/placental-extract","display_name":"placental extract","score":0.7400000095367432},{"id":"https://openalex.org/keywords/beta-endorphin","display_name":"beta-endorphin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/anterior-pituitary-cells","display_name":"anterior pituitary cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tryptic-digestion","display_name":"trypsin digestion","score":0.9049999713897705},{"id":"https://openalex.org/keywords/placental-hormones","display_name":"placental hormones","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C3018059006","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Human placenta","level":5,"score":0.7646950483322144},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7573398351669312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7357606887817383},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.7216094732284546},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6775707006454468},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.5342307090759277},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.519629180431366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4411458373069763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.386233389377594},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.21218883991241455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20594891905784607},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1634344756603241},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14324915409088135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13283565640449524},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1013195812702179},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010924","descriptor_name":"Placental Extracts","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-55-2-384","doi":"https://doi.org/10.1210/jcem-55-2-384","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-55-2-384","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:6282924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6282924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1610873903","https://openalex.org/W1847818636","https://openalex.org/W1992763163","https://openalex.org/W1994015023","https://openalex.org/W2010141967","https://openalex.org/W2025433728","https://openalex.org/W2034027160","https://openalex.org/W2084881904","https://openalex.org/W2093818536","https://openalex.org/W2095036452","https://openalex.org/W2166293213","https://openalex.org/W2320556745"],"related_works":["https://openalex.org/W2312586582","https://openalex.org/W1989852141","https://openalex.org/W2013193095","https://openalex.org/W2068076141","https://openalex.org/W2033103962","https://openalex.org/W2042963758","https://openalex.org/W2045701186","https://openalex.org/W2091477379","https://openalex.org/W2416248548","https://openalex.org/W2068601878"],"abstract_inverted_index":{"Corticotropin-releasing":[0],"factor":[1],"(C":[2],"R":[3,70],"F)-like":[4],"activity,":[5],"which":[6],"was":[7,13,86],"first":[8],"found":[9],"in":[10,15],"the":[11,16,32,50,60,73,80,92],"hypothalamus,":[12],"detected":[14],"extracts":[17],"of":[18,31,41,45,59,75],"human":[19,84,93],"placentas":[20],"obtained":[21],"at":[22],"full":[23],"term":[24],"from":[25,83],"spontaneous":[26],"deliveries.":[27],"The":[28],"molecular":[29],"size":[30],"placental":[33,51],"CRF-like":[34,52,81],"substance":[35,98],"is":[36],"slightly":[37],"larger":[38],"than":[39],"that":[40,58],"adrenocorticotropin.":[42],"In":[43],"cultures":[44],"rat":[46,63],"anterior":[47],"pituitary":[48],"cells,":[49],"material":[53],"shows":[54],"bioactivity":[55],"similar":[56,99],"to":[57,100],"partially":[61],"purified":[62],"hypothalamic":[64,101],"CRF":[65],"and":[66,77],"synthetic":[67],"ovine":[68],"C":[69],"F":[71],"on":[72],"release":[74],"adrenocorticotropin":[76],"(\u03b2-endorphin.":[78],"Furthermore,":[79],"activity":[82],"placenta":[85,94],"attenuated":[87],"by":[88],"trypsin":[89],"digestion.":[90],"Thus":[91],"may":[95],"elaborate":[96],"a":[97],"CRF.":[102]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}