{"id":"https://openalex.org/W2029984151","doi":"https://doi.org/10.1007/bf00211552","title":"The transport of class I major histocompatibility complex antigens is determined by sequences in the ?1 and ?2 protein domains","display_name":"The transport of class I major histocompatibility complex antigens is determined by sequences in the ?1 and ?2 protein domains","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W2029984151","doi":"https://doi.org/10.1007/bf00211552","mag":"2029984151","pmid":"https://pubmed.ncbi.nlm.nih.gov/2318516"},"language":"en","primary_location":{"id":"doi:10.1007/bf00211552","doi":"https://doi.org/10.1007/bf00211552","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00211552","pdf_url":null,"source":{"id":"https://openalex.org/S62103174","display_name":"Immunogenetics","issn_l":"0093-7711","issn":["0093-7711","1432-1211"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunogenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005142142","display_name":"Jeff Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Alexander","raw_affiliation_strings":["Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710","Department of Microbiology & Immunology, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000228614","display_name":"Jonathan Payne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.Alan Payne","raw_affiliation_strings":["Department of Microbiology and Immunology, Duke University Medical Center, 27710, Durham, NC, USA","Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Duke University Medical Center, 27710, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041040042","display_name":"Brian L. Shigekawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Shigekawa","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina, 27599, Chapel Hill, NC, USA","University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina, 27599, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108363587","display_name":"J G Frelinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JeffreyA. Frelinger","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065397632","display_name":"Peter Cresswell","orcid":"https://orcid.org/0000-0003-0540-2351","observed_orcids":["https://orcid.org/0000-0003-0540-2351"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Cresswell","raw_affiliation_strings":["Department of Microbiology and Immunology, Duke University Medical Center, 27710, Durham, NC, USA","Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Duke University Medical Center, 27710, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":null,"fwci":2.9411,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.91516894,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"3","first_page":"169","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.41499999165534973,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.41499999165534973,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.27709999680519104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-a2","display_name":"HLA-A2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hla-b5","display_name":"HLA-B5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hla-b7","display_name":"HLA-B7","score":0.9490000009536743},{"id":"https://openalex.org/keywords/h-2db","display_name":"H-2Db","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cell-surface-expression","display_name":"cell surface expression","score":0.6159999966621399},{"id":"https://openalex.org/keywords/glycosylation-sites","display_name":"glycosylation sites","score":0.8489999771118164},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.4860000014305115},{"id":"https://openalex.org/keywords/glycoprotein-biosynthesis","display_name":"glycoprotein synthesis","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7781758308410645},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6610710620880127},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5488503575325012},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5295642018318176},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5070047378540039},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4959510266780853},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47032630443573},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.460645467042923},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.44712692499160767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43655329942703247},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4320128560066223},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.42989301681518555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36930686235427856},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004560","descriptor_name":"Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015793","descriptor_name":"HLA-B7 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015793","descriptor_name":"HLA-B7 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00211552","doi":"https://doi.org/10.1007/bf00211552","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00211552","pdf_url":null,"source":{"id":"https://openalex.org/S62103174","display_name":"Immunogenetics","issn_l":"0093-7711","issn":["0093-7711","1432-1211"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunogenetics","raw_type":"journal-article"},{"id":"pmid:2318516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2318516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunogenetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2361229906","display_name":null,"funder_award_id":"AI 20288","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7051274373","display_name":"REGULATION OF HLA ANTIGEN EXPRESSION","funder_award_id":"R01AI015775","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W40843633","https://openalex.org/W135710923","https://openalex.org/W309166525","https://openalex.org/W1485388309","https://openalex.org/W1497278722","https://openalex.org/W1510902285","https://openalex.org/W1519202216","https://openalex.org/W1533798391","https://openalex.org/W1578651746","https://openalex.org/W1822598516","https://openalex.org/W1883179501","https://openalex.org/W1899217451","https://openalex.org/W1996832497","https://openalex.org/W2000045443","https://openalex.org/W2000734326","https://openalex.org/W2001347655","https://openalex.org/W2006416369","https://openalex.org/W2010500197","https://openalex.org/W2012033675","https://openalex.org/W2012370844","https://openalex.org/W2016436105","https://openalex.org/W2020140013","https://openalex.org/W2029993034","https://openalex.org/W2031656934","https://openalex.org/W2034168176","https://openalex.org/W2035826838","https://openalex.org/W2036671914","https://openalex.org/W2052430612","https://openalex.org/W2071714160","https://openalex.org/W2074061180","https://openalex.org/W2074737029","https://openalex.org/W2076203549","https://openalex.org/W2079305869","https://openalex.org/W2080757497","https://openalex.org/W2080919590","https://openalex.org/W2082173837","https://openalex.org/W2083453910","https://openalex.org/W2093659679","https://openalex.org/W2109183289","https://openalex.org/W2111364193","https://openalex.org/W2111441225","https://openalex.org/W2113746427","https://openalex.org/W2122291762","https://openalex.org/W2161431416","https://openalex.org/W2161677604","https://openalex.org/W2164179462","https://openalex.org/W2180068303","https://openalex.org/W2491527749","https://openalex.org/W2500437335"],"related_works":["https://openalex.org/W1996832497","https://openalex.org/W2144482507","https://openalex.org/W309166525","https://openalex.org/W1899217451","https://openalex.org/W1999726068","https://openalex.org/W2049873838","https://openalex.org/W2034076362","https://openalex.org/W2074965881","https://openalex.org/W1511989971","https://openalex.org/W1991982391"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}