{"id":"https://openalex.org/W2029944151","doi":"https://doi.org/10.5222/j.child.2010.013","title":"\u00c7ocuklarda Kur\u015fun Zehirlenmesi, Oksidatif Stres ve Tiyol Bile\u015fiklerin Antioksidan Etkisi","display_name":"\u00c7ocuklarda Kur\u015fun Zehirlenmesi, Oksidatif Stres ve Tiyol Bile\u015fiklerin Antioksidan Etkisi","publication_year":2010,"publication_date":"2010-06-30","ids":{"openalex":"https://openalex.org/W2029944151","doi":"https://doi.org/10.5222/j.child.2010.013","mag":"2029944151"},"language":"en","primary_location":{"id":"doi:10.5222/j.child.2010.013","doi":"https://doi.org/10.5222/j.child.2010.013","is_oa":false,"landing_page_url":"https://doi.org/10.5222/j.child.2010.013","pdf_url":null,"source":{"id":"https://openalex.org/S4210217294","display_name":"\u00c7ocuk Dergisi / Journal of Child","issn_l":"1308-8491","issn":["1308-8491","1302-9940"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u00c7ocuk Dergisi / Journal of Child","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11508/26644","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060989271","display_name":"Emrah \u00c7aylak","orcid":"https://orcid.org/0000-0003-0408-9690","observed_orcids":["https://orcid.org/0000-0003-0408-9690"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emrah \u00c7aylak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060989271"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":"1","first_page":"13","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead-poisoning","display_name":"lead poisoning","score":0.9879999756813049},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5519999861717224},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9179999828338623},{"id":"https://openalex.org/keywords/thiols","display_name":"thiols","score":0.878000020980835},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.6769999861717224},{"id":"https://openalex.org/keywords/lead-neurotoxicity","display_name":"lead neurotoxicity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.8939999938011169},{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.9309999942779541},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9779999852180481},{"id":"https://openalex.org/keywords/chelating-agents","display_name":"chelating agents","score":0.8500000238418579},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.9480000138282776},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.9819999933242798},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prooxidant-antioxidant-balance","display_name":"prooxidant-antioxidant balance","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6240000128746033},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8472872376441956},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7405431866645813},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7001200914382935},{"id":"https://openalex.org/C2781037878","wikidata":"https://www.wikidata.org/wiki/Q110315","display_name":"Lead poisoning","level":2,"score":0.6458195447921753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5718198418617249},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4908481240272522},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.47959673404693604},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47044840455055237},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.4702279269695282},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46200722455978394},{"id":"https://openalex.org/C2777093003","wikidata":"https://www.wikidata.org/wiki/Q6508345","display_name":"Lead (geology)","level":2,"score":0.42664048075675964},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.4183214008808136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3761707544326782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3182862401008606},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.24252626299858093},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13018417358398438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1301778256893158},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5222/j.child.2010.013","doi":"https://doi.org/10.5222/j.child.2010.013","is_oa":false,"landing_page_url":"https://doi.org/10.5222/j.child.2010.013","pdf_url":null,"source":{"id":"https://openalex.org/S4210217294","display_name":"\u00c7ocuk Dergisi / Journal of Child","issn_l":"1308-8491","issn":["1308-8491","1302-9940"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u00c7ocuk Dergisi / Journal of Child","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/805421","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/jchild/article/805421","pdf_url":null,"source":{"id":"https://openalex.org/S4210217294","display_name":"\u00c7ocuk Dergisi / Journal of Child","issn_l":"1308-8491","issn":["1308-8491","1302-9940"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/26644","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/26644","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:openaccess.firat.edu.tr:11508/26644","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/26644","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7217589081","https://openalex.org/W2006735624","https://openalex.org/W7201239340","https://openalex.org/W2139766265","https://openalex.org/W2171588737","https://openalex.org/W73101487","https://openalex.org/W4399195745","https://openalex.org/W2058681104","https://openalex.org/W7163370332","https://openalex.org/W7215500735"],"abstract_inverted_index":{"Lead":[0],"causes":[1],"a":[2,33,60,159,224],"great":[3],"environmental":[4],"problem":[5],"because":[6,57],"it\u2019s":[7],"being":[8],"widely":[9],"used":[10],"in":[11,25,76,93,106,145,151,158,176,197,234,241],"the":[12,18,26,118,199],"industry.":[13],"Chronic":[14],"lead":[15,53,64,74,91,102,132,204,232],"intoxication":[16],"is":[17,103],"most":[19],"important":[20],"health":[21],"threat":[22],"to":[23,44,52,168,183,227],"children":[24,239],"World":[27],"and":[28,39,46,84,112,116,121,131,141],"our":[29],"country.":[30],"Children":[31],"have":[32,165,169,223],"developing":[34],"system":[35],"of":[36,63,73,90,110,148,186,191],"cell":[37],"differentiation":[38],"growth":[40],"that\u2019s":[41],"more":[42,50],"vulnerable":[43],"inhibition":[45,109],"damage.":[47,97,153],"They\u2019re":[48],"far":[49],"susceptible":[51],"neurotoxicity":[54],"than":[55],"adults":[56],"they":[58,194],"absorb":[59],"higher":[61],"fraction":[62],"and.":[65],"However,":[66],"it":[67],"has":[68,92,207],"indicated":[69,209],"that":[70,210],"low-level":[71],"exposures":[72],"result":[75],"neurological":[77],"damage,":[78],"cognitive":[79],"dysfunction,":[80],"neurobehavioral":[81],"disorders,":[82],"hypertension,":[83],"renal":[85],"impairment.":[86],"The":[87,123],"mechanism":[88],"all":[89],"common":[94],"involves":[95],"oxidative":[96,152],"Oxidative":[98],"stress":[99],"induced":[100],"by":[101],"seen":[104],"mainly":[105],"erythrocytes":[107,119],"including":[108],"heme":[111],"hemoglobin":[113],"(Hb)":[114],"synthesis,":[115],"changing":[117],"morphology":[120],"survival.":[122],"accumulated":[124],"aminolevulinic":[125],"acid":[126,220],"(ALA)":[127],"induces":[128],"ROS":[129],"generation":[130],"also":[133],"inhibits":[134],"several":[135],"enzymes":[136],"having":[137],"functional":[138],"-SH":[139],"groups":[140],"might":[142],"cause":[143],"impairment":[144],"prooxidant/antioxidant":[146],"balance":[147],"cells,":[149],"resulting":[150],"Thiols":[154],"either":[155],"individually":[156],"or":[157,193,221,238],"combined":[160],"therapy,":[161],"with":[162],"chelating":[163],"agents":[164,180],"been":[166,208],"observed":[167],"beneficial":[170],"effects":[171,190],"against":[172],"lead\u2019s":[173],"detrimental":[174],"properties":[175],"experimental":[177],"studies.":[178],"These":[179],"were":[181],"found":[182],"be":[184],"capable":[185],"abating":[187],"some":[188],"toxic":[189],"lead,":[192],"are":[195],"effective":[196],"rebalancing":[198],"impaired":[200],"pro-oxidant/antioxidant":[201],"ratio":[202],"following":[203],"exposure.":[205],"It":[206],"sulfur":[211],"containing":[212],"antioxidants,":[213],"such":[214],"as":[215],"methionine,":[216],"N-acetylcystein":[217],"(NAC),":[218],"\u03b1-lipoic":[219],"homocysteine,":[222],"novel":[225],"approach":[226],"strategies":[228],"for":[229,231],"preventing":[230],"poisoning":[233],"industrial":[235],"child":[236],"workers":[237],"living":[240],"airpollutions.":[242]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}