{"id":"https://openalex.org/W2029916964","doi":"https://doi.org/10.1016/s0169-5002(03)00076-x","title":"A population-based study of glutathione S-transferase M1, T1 and P1 genotypes and risk for lung cancer","display_name":"A population-based study of glutathione S-transferase M1, T1 and P1 genotypes and risk for lung cancer","publication_year":2003,"publication_date":"2003-03-25","ids":{"openalex":"https://openalex.org/W2029916964","doi":"https://doi.org/10.1016/s0169-5002(03)00076-x","mag":"2029916964","pmid":"https://pubmed.ncbi.nlm.nih.gov/12781423"},"language":"en","primary_location":{"id":"doi:10.1016/s0169-5002(03)00076-x","doi":"https://doi.org/10.1016/s0169-5002(03)00076-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-5002(03)00076-x","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054021722","display_name":"Valle Nazar\u2010Stewart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Valle Nazar-Stewart","raw_affiliation_strings":["Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97201, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011306393","display_name":"Thomas L. Vaughan","orcid":"https://orcid.org/0000-0003-1537-0242","observed_orcids":["https://orcid.org/0000-0003-1537-0242"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas L. Vaughan","raw_affiliation_strings":["Department of Epidemiology, University of Washington, Seattle, WA 98195, USA","Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042914780","display_name":"Patricia Stapleton","orcid":"https://orcid.org/0000-0001-9528-5923","observed_orcids":["https://orcid.org/0000-0001-9528-5923"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Stapleton","raw_affiliation_strings":["Department of Environmental Health, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006718214","display_name":"Jason Loo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Van Loo","raw_affiliation_strings":["Department of Environmental Health, University of Washington, Seattle, WA 98195, USA","GlobalTox, Redmond, WA 98052, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"GlobalTox, Redmond, WA 98052, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039509988","display_name":"Berta Nicol-Blades","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Berta Nicol-Blades","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085883907","display_name":"David L. Eaton","orcid":"https://orcid.org/0000-0003-3121-1380","observed_orcids":["https://orcid.org/0000-0003-3121-1380"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Eaton","raw_affiliation_strings":["Department of Environmental Health, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054021722"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":2.6805,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.90529748,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"40","issue":"3","first_page":"247","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-s-transferase-m1","display_name":"glutathione S-transferase M1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gstm1-null-genotype","display_name":"GSTM1 null genotype","score":0.8289999961853027},{"id":"https://openalex.org/keywords/lung-cancer-risk","display_name":"lung cancer risk","score":0.9350000023841858},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6320000290870667},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7540000081062317},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.7409999966621399},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C2780122483","wikidata":"https://www.wikidata.org/wiki/Q18026593","display_name":"GSTP1","level":4,"score":0.7972919940948486},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7144222259521484},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.689241886138916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6801402568817139},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6296976208686829},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5322107076644897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5238606929779053},{"id":"https://openalex.org/C2776907368","wikidata":"https://www.wikidata.org/wiki/Q307302","display_name":"Glutathione S-transferase","level":4,"score":0.5137951970100403},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5002660751342773},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.487813264131546},{"id":"https://openalex.org/C60034152","wikidata":"https://www.wikidata.org/wiki/Q2130735","display_name":"Random digit dialing","level":3,"score":0.4404504597187042},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3588970899581909},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25687748193740845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21436583995819092},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.19938015937805176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14994555711746216},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07814860343933105},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014861","descriptor_name":"Washington","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051549","descriptor_name":"Glutathione S-Transferase pi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0169-5002(03)00076-x","doi":"https://doi.org/10.1016/s0169-5002(03)00076-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-5002(03)00076-x","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},{"id":"pmid:12781423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12781423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer (Amsterdam, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4405641911","display_name":"EPIDEMIOLOGIC STUDY OF LUNG CANCER AND WOOD DUST","funder_award_id":"R01CA053392","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G477760483","display_name":"EPIDEMIOLOGY OF GLUTATHIONE TRANSFERASE AND LUNG CANCER","funder_award_id":"R01CA062082","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000896837","display_name":"University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment","funder_award_id":"P30ES007033","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W9041372","https://openalex.org/W71469300","https://openalex.org/W113982714","https://openalex.org/W160040655","https://openalex.org/W206382983","https://openalex.org/W1492818624","https://openalex.org/W1530234560","https://openalex.org/W1547383512","https://openalex.org/W1567493178","https://openalex.org/W1585124497","https://openalex.org/W1750764013","https://openalex.org/W1845525687","https://openalex.org/W1891692879","https://openalex.org/W1901874956","https://openalex.org/W1967220405","https://openalex.org/W1968190169","https://openalex.org/W1976056213","https://openalex.org/W1980626524","https://openalex.org/W1988376306","https://openalex.org/W1989327131","https://openalex.org/W2003334606","https://openalex.org/W2009707433","https://openalex.org/W2019711543","https://openalex.org/W2019767718","https://openalex.org/W2021223798","https://openalex.org/W2024527370","https://openalex.org/W2030068197","https://openalex.org/W2035290637","https://openalex.org/W2044692125","https://openalex.org/W2045207944","https://openalex.org/W2046348060","https://openalex.org/W2046750894","https://openalex.org/W2048737938","https://openalex.org/W2049394451","https://openalex.org/W2052447033","https://openalex.org/W2053928154","https://openalex.org/W2066611012","https://openalex.org/W2070924449","https://openalex.org/W2076589905","https://openalex.org/W2098876987","https://openalex.org/W2098980155","https://openalex.org/W2102726642","https://openalex.org/W2103324761","https://openalex.org/W2106008374","https://openalex.org/W2106759295","https://openalex.org/W2109157775","https://openalex.org/W2111729067","https://openalex.org/W2112710602","https://openalex.org/W2122310987","https://openalex.org/W2124840583","https://openalex.org/W2126848032","https://openalex.org/W2130857911","https://openalex.org/W2132561113","https://openalex.org/W2143767691","https://openalex.org/W2155356278","https://openalex.org/W2159210471","https://openalex.org/W2161288249","https://openalex.org/W2164790099","https://openalex.org/W2184557788","https://openalex.org/W2188965485","https://openalex.org/W2255072342","https://openalex.org/W2276327506","https://openalex.org/W2289490936","https://openalex.org/W2397300154","https://openalex.org/W3085323863","https://openalex.org/W6608395175","https://openalex.org/W6631673080","https://openalex.org/W6638947660","https://openalex.org/W6692053135","https://openalex.org/W6712434646"],"related_works":["https://openalex.org/W2130857911","https://openalex.org/W2390932249","https://openalex.org/W1973102049","https://openalex.org/W2007950744","https://openalex.org/W1971766955","https://openalex.org/W2393656477","https://openalex.org/W2562326102","https://openalex.org/W4400851741","https://openalex.org/W2089575319","https://openalex.org/W2154250554"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}