{"id":"https://openalex.org/W2029899080","doi":"https://doi.org/10.1111/j.1440-1843.2005.00687.x","title":"Augmentation of allergic inflammation in the airways of cyclooxygenase\u20102\u2010deficient mice","display_name":"Augmentation of allergic inflammation in the airways of cyclooxygenase\u20102\u2010deficient mice","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W2029899080","doi":"https://doi.org/10.1111/j.1440-1843.2005.00687.x","mag":"2029899080","pmid":"https://pubmed.ncbi.nlm.nih.gov/15823178"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1843.2005.00687.x","doi":"https://doi.org/10.1111/j.1440-1843.2005.00687.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1843.2005.00687.x","pdf_url":null,"source":{"id":"https://openalex.org/S125119059","display_name":"Respirology","issn_l":"1323-7799","issn":["1323-7799","1440-1843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033272841","display_name":"Junko Nakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko NAKATA","raw_affiliation_strings":["First Department of Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku, Tokyo","Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan","First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku, Tokyo","institution_ids":["https://openalex.org/I4210136522"]},{"raw_affiliation_string":"Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan","institution_ids":[]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000260293","display_name":"Mitsuko Kondo","orcid":"https://orcid.org/0000-0003-3673-5431","observed_orcids":["https://orcid.org/0000-0003-3673-5431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuko KONDO","raw_affiliation_strings":["Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan","First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan","institution_ids":[]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046225422","display_name":"Jun Tamaoki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun TAMAOKI","raw_affiliation_strings":["First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009010179","display_name":"Takako Takemiya","orcid":"https://orcid.org/0000-0003-0877-5698","observed_orcids":["https://orcid.org/0000-0003-0877-5698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takako TAKEMIYA","raw_affiliation_strings":["Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan","First Department of Physiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan","institution_ids":[]},{"raw_affiliation_string":"First Department of Physiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023864605","display_name":"Michiko Nohara","orcid":"https://orcid.org/0000-0001-5697-630X","observed_orcids":["https://orcid.org/0000-0001-5697-630X"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiko NOHARA","raw_affiliation_strings":["Second Department of Hygiene and Public Health, Tokyo Women's Medical University School of Medicine, Shinjuku, Tokyo, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Hygiene and Public Health, Tokyo Women's Medical University School of Medicine, Shinjuku, Tokyo, and","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070360043","display_name":"Kanato Yamagata","orcid":"https://orcid.org/0000-0001-6183-2511","observed_orcids":["https://orcid.org/0000-0001-6183-2511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanato YAMAGATA","raw_affiliation_strings":["Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102806617","display_name":"Atsushi Nagai","orcid":"https://orcid.org/0000-0002-9280-8044","observed_orcids":["https://orcid.org/0000-0002-9280-8044"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Atsushi NAGAI","raw_affiliation_strings":["First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102806617"],"corresponding_institution_ids":[],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":2.3976,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.87355533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"149","last_page":"156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/allergic-airway-inflammation","display_name":"allergic airway inflammation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.953000009059906},{"id":"https://openalex.org/keywords/eosinophilic-inflammation","display_name":"eosinophilic inflammation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cysteinyl-leukotrienes","display_name":"cysteinyl leukotrienes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.972000002861023},{"id":"https://openalex.org/keywords/mucous-metaplasia","display_name":"mucous cell metaplasia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nimesulide","display_name":"nimesulide","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ovalbumin-sensitization","display_name":"ovalbumin sensitization","score":0.8830000162124634},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.7559999823570251},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9020000100135803},{"id":"https://openalex.org/keywords/serum-ige","display_name":"serum IgE","score":0.7680000066757202},{"id":"https://openalex.org/keywords/airway-responsiveness","display_name":"airway responsiveness","score":0.6729999780654907},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolites","display_name":"arachidonic acid metabolites","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7841366529464722},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.7102714776992798},{"id":"https://openalex.org/C2777570176","wikidata":"https://www.wikidata.org/wiki/Q20994","display_name":"Nimesulide","level":2,"score":0.6839991807937622},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6026454567909241},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5726686120033264},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.5404411554336548},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5348984003067017},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5106173157691956},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.48579978942871094},{"id":"https://openalex.org/C2779675166","wikidata":"https://www.wikidata.org/wiki/Q4732119","display_name":"Allergic inflammation","level":3,"score":0.48273131251335144},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.42869699001312256},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4257696270942688},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.2918398678302765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22478130459785461},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.20132943987846375},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11516982316970825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09455698728561401},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.07305458188056946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016085","descriptor_name":"Bronchoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1843.2005.00687.x","doi":"https://doi.org/10.1111/j.1440-1843.2005.00687.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1843.2005.00687.x","pdf_url":null,"source":{"id":"https://openalex.org/S125119059","display_name":"Respirology","issn_l":"1323-7799","issn":["1323-7799","1440-1843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology","raw_type":"journal-article"},{"id":"pmid:15823178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15823178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology (Carlton, Vic.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W176925653","https://openalex.org/W1530739311","https://openalex.org/W1640486693","https://openalex.org/W1847502419","https://openalex.org/W1978730128","https://openalex.org/W1979655911","https://openalex.org/W1985844039","https://openalex.org/W2001193292","https://openalex.org/W2029251290","https://openalex.org/W2038629059","https://openalex.org/W2045744166","https://openalex.org/W2078387296","https://openalex.org/W2083651943","https://openalex.org/W2086309760","https://openalex.org/W2098727834","https://openalex.org/W2124566107","https://openalex.org/W2136329370","https://openalex.org/W2137230722","https://openalex.org/W2153231621","https://openalex.org/W2162960865","https://openalex.org/W2163885960","https://openalex.org/W2165362506","https://openalex.org/W2169282830","https://openalex.org/W2331980604","https://openalex.org/W2800526221"],"related_works":["https://openalex.org/W2078387296","https://openalex.org/W2340054484","https://openalex.org/W2067295873","https://openalex.org/W2169282830","https://openalex.org/W2048346901","https://openalex.org/W2169932060","https://openalex.org/W2147633425","https://openalex.org/W1951495304","https://openalex.org/W2099091298","https://openalex.org/W2024273982"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Airway":[1],"cyclooxygenase-2":[2],"(COX-2)":[3],"is":[4,24],"induced":[5],"by":[6],"cytokine-mediated":[7],"inflammation":[8,200],"such":[9],"as":[10,128,130],"occurs":[11],"in":[12,19,42,77,101,105,111,136,175],"asthma.":[13],"However,":[14,144],"the":[15,20,43,93,97],"role":[16],"of":[17,22,45,69,84,99,118,164],"COX-2":[18,46,50,60,107,113,137,141,146,159,176,196],"pathophysiology":[21],"asthma":[23],"not":[25,134],"fully":[26],"understood.":[27],"METHODS:":[28],"Allergic":[29],"inflammation,":[30,184],"airway":[31,94,131,167],"responsiveness":[32,132],"to":[33],"methacholine":[34],"and":[35,53,73,82,96,125,140,152,170,187,201],"mucous":[36,188,202],"cell":[37,66,189,203],"metaplasia":[38],"after":[39],"ovalbumin":[40],"sensitization":[41],"airways":[44],"deficient":[47],"(-/-)":[48,108,138,147,160,177],"mice,":[49],"(+/+)":[51,114,142],"mice":[52,55,109,139,148,180],"C57BL/6J":[54],"treated":[56],"with":[57,157],"a":[58],"selective":[59],"inhibitor,":[61],"nimesulide":[62],"were":[63,87,103,173],"assessed.":[64],"Histology,":[65],"analysis,":[67],"measurements":[68],"arachidonic":[70],"acid":[71],"metabolites":[72],"Th2":[74],"cytokine":[75],"levels":[76,117],"bronchoalveolar":[78],"lavage":[79],"fluid":[80],"(BALF),":[81],"measurement":[83],"serum":[85,171],"IgE":[86,172],"performed.":[88],"RESULTS:":[89],"Eosinophil":[90],"infiltration":[91],"into":[92],"wall,":[95],"number":[98,163],"eosinophils":[100],"BALF":[102],"greater":[104],"sensitized":[106,112,145],"than":[110],"mice.":[115,143,161,178],"The":[116,162],"cysteinyl":[119],"leukotrienes":[120],"(LTC4/D4/E4),":[121],"prostaglandin":[122],"E2":[123],"(PGE2)":[124],"interleukin":[126],"(IL)-13":[127],"well":[129],"did":[133],"differ":[135],"had":[149],"higher":[150],"LTC4/D4/E4":[151,185],"lower":[153],"PGE2":[154],"concentrations":[155,186],"compared":[156],"non-sensitized":[158],"PAS/alcian":[165],"blue-positive":[166],"epithelial":[168],"cells":[169],"elevated":[174],"Nimesulide-treated":[179],"showed":[181],"augmented":[182],"eosinophilic":[183],"metaplasia.":[190,204],"CONCLUSION:":[191],"These":[192],"data":[193],"indicate":[194],"that":[195],"deficiency":[197],"augments":[198],"allergic":[199]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}