{"id":"https://openalex.org/W2029889596","doi":"https://doi.org/10.1159/000226566","title":"Effects of PSK on Resistance to Bacterial Infection in Splenectomized Mice","display_name":"Effects of PSK on Resistance to Bacterial Infection in Splenectomized Mice","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W2029889596","doi":"https://doi.org/10.1159/000226566","mag":"2029889596","pmid":"https://pubmed.ncbi.nlm.nih.gov/3285280"},"language":"en","primary_location":{"id":"doi:10.1159/000226566","doi":"https://doi.org/10.1159/000226566","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000226566","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061847665","display_name":"Takao Ando","orcid":"https://orcid.org/0000-0003-0884-3873","observed_orcids":["https://orcid.org/0000-0003-0884-3873"]},"institutions":[{"id":"https://openalex.org/I4210132614","display_name":"Kureha (Japan)","ror":"https://ror.org/03a23ph14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132614"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Ando","raw_affiliation_strings":["Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, Japan","Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, Japan","institution_ids":["https://openalex.org/I4210132614"]},{"raw_affiliation_string":"Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and","institution_ids":["https://openalex.org/I4210132614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040167603","display_name":"Isamu Motokawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132614","display_name":"Kureha (Japan)","ror":"https://ror.org/03a23ph14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132614"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isamu Motokawa","raw_affiliation_strings":["Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and","institution_ids":["https://openalex.org/I4210132614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083789734","display_name":"Katsuo Sakurai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132614","display_name":"Kureha (Japan)","ror":"https://ror.org/03a23ph14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132614"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuo Sakurai","raw_affiliation_strings":["Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and","institution_ids":["https://openalex.org/I4210132614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080107109","display_name":"Yoshio Ohmura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132614","display_name":"Kureha (Japan)","ror":"https://ror.org/03a23ph14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132614"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Ohmura","raw_affiliation_strings":["Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and","institution_ids":["https://openalex.org/I4210132614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036730770","display_name":"Kenichi Matsunaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132614","display_name":"Kureha (Japan)","ror":"https://ror.org/03a23ph14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132614"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Matsunaga","raw_affiliation_strings":["Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and","institution_ids":["https://openalex.org/I4210132614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076425456","display_name":"CHIKAO YOSHIKUMI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132614","display_name":"Kureha (Japan)","ror":"https://ror.org/03a23ph14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132614"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikao Yoshikumi","raw_affiliation_strings":["Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and","institution_ids":["https://openalex.org/I4210132614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112141513","display_name":"T Taguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Taguchi","raw_affiliation_strings":["Department of Oncologic Surgery, Research Institute for Medical Diseases, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncologic Surgery, Research Institute for Medical Diseases, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111430211","display_name":"Takayoshi Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132614","display_name":"Kureha (Japan)","ror":"https://ror.org/03a23ph14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132614"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Fujii","raw_affiliation_strings":["Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Laboratories, Kureha Chemical Industry Co., Ldt., Tokyo, and","institution_ids":["https://openalex.org/I4210132614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"3","first_page":"224","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.22310000658035278,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.22310000658035278,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.19779999554157257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psk","display_name":"PSK","score":0.9190000295639038},{"id":"https://openalex.org/keywords/kampo-medicine","display_name":"Kampo medicine","score":0.5170000195503235},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bacterial-infection-resistance","display_name":"bacterial infection resistance","score":0.8949999809265137},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":1.0},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9980000257492065},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.6380000114440918},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5830000042915344},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5249999761581421},{"id":"https://openalex.org/keywords/c3h-he-mice","display_name":"C3H/He mice","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4298037588596344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40519633889198303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3782554268836975},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36708304286003113},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.35610654950141907}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010954","descriptor_name":"Plasmacytoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013156","descriptor_name":"Splenectomy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000226566","doi":"https://doi.org/10.1159/000226566","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000226566","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},{"id":"pmid:3285280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3285280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982630188","https://openalex.org/W2120558696","https://openalex.org/W2316748904","https://openalex.org/W1977801336","https://openalex.org/W2030007442","https://openalex.org/W2415340593","https://openalex.org/W259690489","https://openalex.org/W1986728170","https://openalex.org/W2078962915","https://openalex.org/W2329238832"],"abstract_inverted_index":{"Nontumor-bearing":[0],"C3H/He":[1],"mice":[2],"were":[3,58],"splenectomized":[4],"and":[5,56,80,88],"intravenously":[6],"inoculated":[7,29,39,59,73],"7":[8,60],"days":[9,51,61],"later":[10],"with":[11,30,40,74],"Streptococcus":[12],"pneumoniae,":[13,32],"Pseudomonas":[14],"aeruginosa,":[15],"or":[16,43,77],"Escherichia":[17],"coli.":[18,45],"The":[19],"survival":[20,66],"rate":[21,67],"was":[22,48,68,90,98],"reduced":[23,69],"by":[24,100],"splenectomy":[25,47],"in":[26,37,71,94],"the":[27,63,65,83,86,106],"animals":[28],"S.":[31],"but":[33],"did":[34],"not":[35],"change":[36],"those":[38,72],"P.":[41,75],"aeruginosa":[42,76],"E.":[44,78],"When":[46],"performed":[49],"2":[50],"after":[52,62,105],"transplantation":[53],"of":[54,82,103],"X5563,":[55],"bacteria":[57,84],"operation,":[64],"even":[70],"coli,":[79],"elimination":[81],"from":[85],"blood":[87],"liver":[89],"delayed.":[91],"This":[92],"reduction":[93],"resistance":[95],"to":[96],"infection":[97],"alleviated":[99],"oral":[101],"administration":[102],"PSK":[104],"splenectomy.":[107]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}