{"id":"https://openalex.org/W2029880965","doi":"https://doi.org/10.1124/jpet.113.204420","title":"Development of a Novel Long-Acting Antidiabetic FGF21 Mimetic by Targeted Conjugation to a Scaffold Antibody","display_name":"Development of a Novel Long-Acting Antidiabetic FGF21 Mimetic by Targeted Conjugation to a Scaffold Antibody","publication_year":2013,"publication_date":"2013-05-29","ids":{"openalex":"https://openalex.org/W2029880965","doi":"https://doi.org/10.1124/jpet.113.204420","mag":"2029880965","pmid":"https://pubmed.ncbi.nlm.nih.gov/23720456"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.113.204420","doi":"https://doi.org/10.1124/jpet.113.204420","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.113.204420","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jie Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Huang","raw_affiliation_strings":["CovX Research, Pfizer Worldwide Research and Development, San Diego, California, USA","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research, Pfizer Worldwide Research and Development, San Diego, California, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052750879","display_name":"Tetsuya Ishino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tetsuya Ishino","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389302","display_name":"Gang Chen","orcid":"https://orcid.org/0000-0002-9989-2381","observed_orcids":["https://orcid.org/0000-0002-9989-2381","https://orcid.org/0000-0003-0650-1175","https://orcid.org/0000-0002-9901-1927","https://orcid.org/0000-0002-0748-5026"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Chen","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027500883","display_name":"Paul Rolzin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Rolzin","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074854892","display_name":"Trina Osothprarop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trina F. Osothprarop","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061288503","display_name":"Kelsey N. Retting","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsey Retting","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065723263","display_name":"Lingna Li","orcid":"https://orcid.org/0009-0004-7840-9372","observed_orcids":["https://orcid.org/0009-0004-7840-9372"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingna Li","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Jin","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003355029","display_name":"Marla J. Matin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marla J. Matin","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020288581","display_name":"Bernard G. Huyghe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard Huyghe","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059226106","display_name":"Saswata Talukdar","orcid":"https://orcid.org/0000-0003-3042-0025","observed_orcids":["https://orcid.org/0000-0003-3042-0025"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saswata Talukdar","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111484509","display_name":"Curt W. Bradshaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curt W. Bradshaw","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060045107","display_name":"Moorthy S. S. Palanki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moorthy Palanki","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113039214","display_name":"Bernard N. Violand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard N. Violand","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072560640","display_name":"Gary Woodnutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Woodnutt","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008645649","display_name":"Rodney W. Lappe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodney W. Lappe","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040196922","display_name":"Kathleen M. Ogilvie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Ogilvie","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":null,"display_name":"Nancy Levin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Levin","raw_affiliation_strings":["CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California; Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts; and Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Bioprocess R&D, Pfizer Worldwide Research and Development, Chesterfield, Missouri (B.N.V.)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"CovX Research (J.H., G.C., P.R., T.F.O., K.R., L.L., P.J., M.J.M., C.W.B., M.P., G.W., R.W.L., K.O., N.L.), Biotherapeutics External Affairs (B.H.), Pfizer Worldwide Research and Development, San Diego, California","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Global Biotherapeutics Technologies (T.I.), CVMED Research Unit (S.T.), Pfizer Worldwide Research and Development, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.3989,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.96149255,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"346","issue":"2","first_page":"270","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf21","display_name":"FGF21","score":0.9430000185966492},{"id":"https://openalex.org/keywords/protein-conjugation","display_name":"protein conjugation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/long-acting-drugs","display_name":"long-acting drugs","score":0.6290000081062317},{"id":"https://openalex.org/keywords/protein-half-life-extension","display_name":"protein half-life extension","score":0.7429999709129333},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.8289999961853027},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.6570000052452087},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C106646824","wikidata":"https://www.wikidata.org/wiki/Q5425475","display_name":"FGF21","level":4,"score":0.8196706771850586},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5911330580711365},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5591562986373901},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5278133153915405},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.46961456537246704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4472551643848419},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.4468921422958374},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.424063503742218},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.42286139726638794},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4219251275062561},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4132065773010254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3860941529273987},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3808063864707947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3022860884666443},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.29391565918922424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24127337336540222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2179199457168579},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2057468593120575},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.0928213894367218},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07531660795211792},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018716","descriptor_name":"Molecular Mimicry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1124/jpet.113.204420","doi":"https://doi.org/10.1124/jpet.113.204420","is_oa":false,"landing_page_url":"https://doi.org/10.1124/jpet.113.204420","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},{"id":"pmid:23720456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23720456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacology and experimental therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.961.7851","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.961.7851","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jpet.aspetjournals.org/content/early/2013/05/29/jpet.113.204420.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.965.3896","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.965.3896","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jpet.aspetjournals.org/content/346/2/270.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W31735925","https://openalex.org/W1977516373","https://openalex.org/W1984580814","https://openalex.org/W1986602268","https://openalex.org/W1988869711","https://openalex.org/W2000665430","https://openalex.org/W2012853495","https://openalex.org/W2020597644","https://openalex.org/W2025629542","https://openalex.org/W2027239974","https://openalex.org/W2032787352","https://openalex.org/W2037318910","https://openalex.org/W2043531340","https://openalex.org/W2047188856","https://openalex.org/W2048285167","https://openalex.org/W2048411348","https://openalex.org/W2061333499","https://openalex.org/W2061512091","https://openalex.org/W2074337024","https://openalex.org/W2076037986","https://openalex.org/W2110534048","https://openalex.org/W2111653877","https://openalex.org/W2114650931","https://openalex.org/W2119331212","https://openalex.org/W2119351413","https://openalex.org/W2121049950","https://openalex.org/W2130700195","https://openalex.org/W2131622156","https://openalex.org/W2134810803","https://openalex.org/W2144461742","https://openalex.org/W2145142659","https://openalex.org/W2150475621","https://openalex.org/W2155010729","https://openalex.org/W2168118376","https://openalex.org/W2184710619","https://openalex.org/W3147971809"],"related_works":["https://openalex.org/W7098181097","https://openalex.org/W3107896769","https://openalex.org/W2806909958","https://openalex.org/W3028256246","https://openalex.org/W2003495422","https://openalex.org/W4408530077","https://openalex.org/W2168118376","https://openalex.org/W2611434197","https://openalex.org/W2145044799","https://openalex.org/W7096369151"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}