{"id":"https://openalex.org/W2029865657","doi":"https://doi.org/10.1016/j.lfs.2004.05.026","title":"DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice","display_name":"DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice","publication_year":2004,"publication_date":"2004-09-14","ids":{"openalex":"https://openalex.org/W2029865657","doi":"https://doi.org/10.1016/j.lfs.2004.05.026","mag":"2029865657","pmid":"https://pubmed.ncbi.nlm.nih.gov/15464829"},"language":"en","primary_location":{"id":"doi:10.1016/j.lfs.2004.05.026","doi":"https://doi.org/10.1016/j.lfs.2004.05.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2004.05.026","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037000230","display_name":"Susan A. Farr","orcid":"https://orcid.org/0000-0002-0481-2570","observed_orcids":["https://orcid.org/0000-0002-0481-2570"]},"institutions":[{"id":"https://openalex.org/I4210104016","display_name":"St. Louis VA Medical Center","ror":"https://ror.org/014c68a74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104016","https://openalex.org/I4210150881","https://openalex.org/I4210165236"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan A. Farr","raw_affiliation_strings":["Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA. FarrSA52@aol.com","Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA. FarrSA52@aol.com","institution_ids":["https://openalex.org/I4210104016"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210104016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054959155","display_name":"William A. Banks","orcid":"https://orcid.org/0000-0002-0496-3619","observed_orcids":["https://orcid.org/0000-0002-0496-3619"]},"institutions":[{"id":"https://openalex.org/I4210104016","display_name":"St. Louis VA Medical Center","ror":"https://ror.org/014c68a74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104016","https://openalex.org/I4210150881","https://openalex.org/I4210165236"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Banks","raw_affiliation_strings":["Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210104016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063733253","display_name":"Kayoko Uezu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104016","display_name":"St. Louis VA Medical Center","ror":"https://ror.org/014c68a74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104016","https://openalex.org/I4210150881","https://openalex.org/I4210165236"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayoko Uezu","raw_affiliation_strings":["Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210104016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005496751","display_name":"Frederich S. Gaskin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104016","display_name":"St. Louis VA Medical Center","ror":"https://ror.org/014c68a74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104016","https://openalex.org/I4210150881","https://openalex.org/I4210165236"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Spencer Gaskin","raw_affiliation_strings":["Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210104016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102748794","display_name":"John Edward Morley","orcid":"https://orcid.org/0000-0003-1104-0393","observed_orcids":["https://orcid.org/0000-0003-1104-0393"]},"institutions":[{"id":"https://openalex.org/I4210104016","display_name":"St. Louis VA Medical Center","ror":"https://ror.org/014c68a74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104016","https://openalex.org/I4210150881","https://openalex.org/I4210165236"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Morley","raw_affiliation_strings":["Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210104016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037000230"],"corresponding_institution_ids":["https://openalex.org/I4210104016","https://openalex.org/I47838141"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.4401,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.80484021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"75","issue":"23","first_page":"2775","last_page":"2785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.9649999737739563},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.8539999723434448},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6359999775886536},{"id":"https://openalex.org/keywords/samp8-mice","display_name":"SAMP8 mice","score":0.9409999847412109},{"id":"https://openalex.org/keywords/alzheimer-s-disease-model","display_name":"Alzheimer's disease model","score":0.9309999942779541},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.878000020980835},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8240000009536743},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8650000095367432},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5770000219345093},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.749346137046814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7014091610908508},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6448298692703247},{"id":"https://openalex.org/C2911120302","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozocin","level":4,"score":0.6371868848800659},{"id":"https://openalex.org/C2780657110","wikidata":"https://www.wikidata.org/wiki/Q2505402","display_name":"Dehydroepiandrosterone sulfate","level":4,"score":0.5037176012992859},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.5001466274261475},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.4889325201511383},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4784412682056427},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.47836536169052124},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4589698016643524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4433170557022095},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.369622141122818},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3682357668876648},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2806864380836487},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.24705630540847778},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17324531078338623},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.15087440609931946}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019314","descriptor_name":"Dehydroepiandrosterone Sulfate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019314","descriptor_name":"Dehydroepiandrosterone Sulfate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lfs.2004.05.026","doi":"https://doi.org/10.1016/j.lfs.2004.05.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2004.05.026","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:15464829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15464829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1578812414","https://openalex.org/W1692093387","https://openalex.org/W1968354728","https://openalex.org/W1968598354","https://openalex.org/W1972445309","https://openalex.org/W1975127665","https://openalex.org/W1980226703","https://openalex.org/W1985046734","https://openalex.org/W1989366358","https://openalex.org/W2003230660","https://openalex.org/W2007691849","https://openalex.org/W2010222033","https://openalex.org/W2012834750","https://openalex.org/W2014823486","https://openalex.org/W2019018379","https://openalex.org/W2019395015","https://openalex.org/W2020036669","https://openalex.org/W2024977010","https://openalex.org/W2035881836","https://openalex.org/W2041633167","https://openalex.org/W2057346271","https://openalex.org/W2068893105","https://openalex.org/W2069017339","https://openalex.org/W2073704332","https://openalex.org/W2074054937","https://openalex.org/W2076725316","https://openalex.org/W2077212501","https://openalex.org/W2087495709","https://openalex.org/W2090881453","https://openalex.org/W2096374955","https://openalex.org/W2096410114","https://openalex.org/W2104373981","https://openalex.org/W2124135429","https://openalex.org/W2126072473","https://openalex.org/W2128250419","https://openalex.org/W2129644963","https://openalex.org/W2140745647","https://openalex.org/W2148516306","https://openalex.org/W2344095183","https://openalex.org/W4406065727","https://openalex.org/W6875925659"],"related_works":["https://openalex.org/W2020036669","https://openalex.org/W2015568605","https://openalex.org/W2375666493","https://openalex.org/W1918835878","https://openalex.org/W3032067608","https://openalex.org/W2071415161","https://openalex.org/W1657419816","https://openalex.org/W1964427298","https://openalex.org/W2045907289","https://openalex.org/W2003524311"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
