{"id":"https://openalex.org/W2029601413","doi":"https://doi.org/10.1016/s0165-4608(96)00149-5","title":"Loss of heterozygosity on chromosome 22 in human gliomas does not inactivate the neurofibromatosis type 2 gene","display_name":"Loss of heterozygosity on chromosome 22 in human gliomas does not inactivate the neurofibromatosis type 2 gene","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2029601413","doi":"https://doi.org/10.1016/s0165-4608(96)00149-5","mag":"2029601413","pmid":"https://pubmed.ncbi.nlm.nih.gov/8956876"},"language":"en","primary_location":{"id":"doi:10.1016/s0165-4608(96)00149-5","doi":"https://doi.org/10.1016/s0165-4608(96)00149-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-4608(96)00149-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210175027","display_name":"Cancer Genetics and Cytogenetics","issn_l":"0165-4608","issn":["0165-4608","1873-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics and Cytogenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102801968","display_name":"David Watkins","orcid":"https://orcid.org/0000-0002-3930-5990","observed_orcids":["https://orcid.org/0000-0002-3930-5990"]},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David Watkins","raw_affiliation_strings":["Department of Medicine, McGill University, Montreal General Hospital Research Institute, Quebec, Canada","Division of Medical Genetics, Department of Medicine, McGill University and Montreal General Hospital Research Institute, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University, Montreal General Hospital Research Institute, Quebec, Canada","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Division of Medical Genetics, Department of Medicine, McGill University and Montreal General Hospital Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109241877","display_name":"Martin H. Ruttledge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Martin H. Ruttledge","raw_affiliation_strings":["Centre for Research in Neuroscience, McHill University and the Montreal General Hospital, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research in Neuroscience, McHill University and the Montreal General Hospital, Montreal, Canada","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071745540","display_name":"Julie Sarrazin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julie Sarrazin","raw_affiliation_strings":["Centre for Research in Neuroscience, McHill University and the Montreal General Hospital, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research in Neuroscience, McHill University and the Montreal General Hospital, Montreal, Canada","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001095959","display_name":"Shyam Rangaratnam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shyam Rangaratnam","raw_affiliation_strings":["Division of Medical Genetics, Department of Medicine, McGill University and Montreal General Hospital Research Institute, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Medicine, McGill University and Montreal General Hospital Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113659712","display_name":"Michel Poisson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Poisson","raw_affiliation_strings":["Clinique Neurologique, H\u00f4pital de la Salpetri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinique Neurologique, H\u00f4pital de la Salpetri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113509038","display_name":"Jean\u2010Yves Delattre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Yves Delattre","raw_affiliation_strings":["Clinique Neurologique, H\u00f4pital de la Salpetri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinique Neurologique, H\u00f4pital de la Salpetri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I4210121705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002628021","display_name":"Guy Armand Rouleau","orcid":"https://orcid.org/0000-0001-8403-1418","observed_orcids":["https://orcid.org/0000-0001-8403-1418","https://orcid.org/0000-0002-6665-8572"]},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Guy A. Rouleau","raw_affiliation_strings":["Centre for Research in Neuroscience, McHill University and the Montreal General Hospital, Montreal, Canada","Division of Medical Genetics, Department of Medicine, McGill University and Montreal General Hospital Research Institute, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research in Neuroscience, McHill University and the Montreal General Hospital, Montreal, Canada","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Division of Medical Genetics, Department of Medicine, McGill University and Montreal General Hospital Research Institute, Montreal, Canada","institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102801968"],"corresponding_institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":0.5939,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.69729087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"92","issue":"1","first_page":"73","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.4332999885082245,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.7329999804496765},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/chromosome-22","display_name":"chromosome 22","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neurofibromatosis-type-2","display_name":"neurofibromatosis type 2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nf2-gene","display_name":"NF2 gene","score":0.921999990940094},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.9533629417419434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8778949975967407},{"id":"https://openalex.org/C2778679214","wikidata":"https://www.wikidata.org/wiki/Q1935832","display_name":"Neurofibromatosis type 2","level":3,"score":0.7452787160873413},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.7217317223548889},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6328753232955933},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5699281692504883},{"id":"https://openalex.org/C54815482","wikidata":"https://www.wikidata.org/wiki/Q753805","display_name":"Chromosome 22","level":4,"score":0.47695934772491455},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4408853352069855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42314258217811584},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4030624330043793},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.37913277745246887},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.37279972434043884}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002892","descriptor_name":"Chromosomes, Human, Pair 22","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016515","descriptor_name":"Genes, Neurofibromatosis 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0165-4608(96)00149-5","doi":"https://doi.org/10.1016/s0165-4608(96)00149-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-4608(96)00149-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210175027","display_name":"Cancer Genetics and Cytogenetics","issn_l":"0165-4608","issn":["0165-4608","1873-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics and Cytogenetics","raw_type":"journal-article"},{"id":"pmid:8956876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8956876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genetics and cytogenetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W56001303","https://openalex.org/W1499660750","https://openalex.org/W1508293099","https://openalex.org/W1510808361","https://openalex.org/W1565264715","https://openalex.org/W1602193081","https://openalex.org/W1625822356","https://openalex.org/W1757036739","https://openalex.org/W1953089061","https://openalex.org/W1970064206","https://openalex.org/W1970825472","https://openalex.org/W1986036115","https://openalex.org/W1987979676","https://openalex.org/W1995263093","https://openalex.org/W2005542290","https://openalex.org/W2011322702","https://openalex.org/W2029976610","https://openalex.org/W2037615726","https://openalex.org/W2039270226","https://openalex.org/W2044572158","https://openalex.org/W2049078537","https://openalex.org/W2055077823","https://openalex.org/W2058924825","https://openalex.org/W2067535577","https://openalex.org/W2070491420","https://openalex.org/W2071639722","https://openalex.org/W2075533513","https://openalex.org/W2075832744","https://openalex.org/W2082089218","https://openalex.org/W2083193857","https://openalex.org/W2090040363","https://openalex.org/W2091829740","https://openalex.org/W2096279412","https://openalex.org/W2121978023","https://openalex.org/W2131430885","https://openalex.org/W2137189485","https://openalex.org/W2137273750","https://openalex.org/W2149494523","https://openalex.org/W2151242353","https://openalex.org/W2152649399","https://openalex.org/W2155035604","https://openalex.org/W2161807488","https://openalex.org/W2165696859","https://openalex.org/W3106696394","https://openalex.org/W6629644637","https://openalex.org/W6630689852","https://openalex.org/W6633823229","https://openalex.org/W6636609944","https://openalex.org/W6637646610","https://openalex.org/W6640729380","https://openalex.org/W6680397612","https://openalex.org/W6682312169"],"related_works":["https://openalex.org/W2016713962","https://openalex.org/W6959404237","https://openalex.org/W2096279412","https://openalex.org/W2017535142","https://openalex.org/W1974362138","https://openalex.org/W2070491420","https://openalex.org/W2062135564","https://openalex.org/W2003455333","https://openalex.org/W152361454","https://openalex.org/W1565264715"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}