{"id":"https://openalex.org/W2029600784","doi":"https://doi.org/10.1002/1096-911x(20001201)35:6<669::aid-mpo40>3.0.co;2-o","title":"Differential expression in an antisenseMYCN neuroblastoma model","display_name":"Differential expression in an antisenseMYCN neuroblastoma model","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2029600784","doi":"https://doi.org/10.1002/1096-911x(20001201)35:6<669::aid-mpo40>3.0.co;2-o","mag":"2029600784","pmid":"https://pubmed.ncbi.nlm.nih.gov/11107143"},"language":"en","primary_location":{"id":"doi:10.1002/1096-911x(20001201)35:6<669::aid-mpo40>3.0.co;2-o","doi":"https://doi.org/10.1002/1096-911x(20001201)35:6<669::aid-mpo40>3.0.co;2-o","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1096-911x(20001201)35:6<669::aid-mpo40>3.0.co;2-o","pdf_url":null,"source":{"id":"https://openalex.org/S179546387","display_name":"Medical and Pediatric Oncology","issn_l":"0098-1532","issn":["0098-1532","1096-911X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320571","host_organization_name":"Alan R. Liss, Inc.","host_organization_lineage":["https://openalex.org/P4310320571"],"host_organization_lineage_names":["Alan R. Liss, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and Pediatric Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109052779","display_name":"Mary Lou Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary Lou Schmidt","raw_affiliation_strings":["Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, USA. mls3@uic.edu","Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, USA. mls3@uic.edu","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005668427","display_name":"Ashutosh Lal","orcid":"https://orcid.org/0000-0003-0082-3536","observed_orcids":["https://orcid.org/0000-0003-0082-3536"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashutosh Lal","raw_affiliation_strings":["Department of Pediatrics University of Illinois at Chicago Chicago Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics University of Illinois at Chicago Chicago Illinois","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081520837","display_name":"David Dittmann","orcid":"https://orcid.org/0009-0005-6758-9176","observed_orcids":["https://orcid.org/0009-0005-6758-9176"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Dittmann","raw_affiliation_strings":["Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109052779"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"6","first_page":"669","last_page":"672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.8090000152587891},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.890999972820282},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.921999990940094},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.7770812511444092},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.6692683696746826},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6654027104377747},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.6126471757888794},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.552542507648468},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.536492645740509},{"id":"https://openalex.org/C79029880","wikidata":"https://www.wikidata.org/wiki/Q901755","display_name":"GenBank","level":3,"score":0.5360764265060425},{"id":"https://openalex.org/C2776657240","wikidata":"https://www.wikidata.org/wiki/Q5275341","display_name":"Differential display","level":4,"score":0.5337411165237427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4961188733577728},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.4456685483455658},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41424036026000977},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3659471273422241},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34522104263305664}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016375","descriptor_name":"Antisense Elements (Genetics)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1096-911x(20001201)35:6<669::aid-mpo40>3.0.co;2-o","doi":"https://doi.org/10.1002/1096-911x(20001201)35:6<669::aid-mpo40>3.0.co;2-o","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1096-911x(20001201)35:6<669::aid-mpo40>3.0.co;2-o","pdf_url":null,"source":{"id":"https://openalex.org/S179546387","display_name":"Medical and Pediatric Oncology","issn_l":"0098-1532","issn":["0098-1532","1096-911X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320571","host_organization_name":"Alan R. Liss, Inc.","host_organization_lineage":["https://openalex.org/P4310320571"],"host_organization_lineage_names":["Alan R. Liss, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and Pediatric Oncology","raw_type":"journal-article"},{"id":"pmid:11107143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11107143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and pediatric oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W66296664","https://openalex.org/W1513717105","https://openalex.org/W1899148250","https://openalex.org/W1978368163","https://openalex.org/W1981028064","https://openalex.org/W1987666378","https://openalex.org/W2010888033","https://openalex.org/W2021243296","https://openalex.org/W2044033792","https://openalex.org/W2070343898","https://openalex.org/W2135914020","https://openalex.org/W2144634347","https://openalex.org/W2151547689","https://openalex.org/W2329408473","https://openalex.org/W2330923897","https://openalex.org/W2416226353","https://openalex.org/W4213387068","https://openalex.org/W7048635666"],"related_works":["https://openalex.org/W2154329308","https://openalex.org/W1948356811","https://openalex.org/W2070950752","https://openalex.org/W1974812652","https://openalex.org/W1932339903","https://openalex.org/W2001471954","https://openalex.org/W2399295847","https://openalex.org/W2140709698","https://openalex.org/W2027054990","https://openalex.org/W1488237084"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,56],"previously":[2],"published":[3],"antisense":[4],"MYCN-expressing":[5,37,87],"model":[6],"system":[7],"was":[8,69],"utilized":[9],"to":[10,34],"identify":[11],"genes":[12],"whose":[13],"expression":[14,54,68],"is":[15,82,100],"altered":[16],"by":[17,22,76],"the":[18,64,74,85,93,103,130],"down-regulation":[19],"of":[20,63,73,123,132],"MYCN":[21,133],"AS":[23,36,86],"MYCN.":[24],"RESULTS:":[25,80],"Differential":[26,67],"display":[27],"comparing":[28],"nontransfected":[29],"human":[30],"NB":[31],"NBL-S":[32,107],"cells":[33,108],"three":[35],"cell":[38],"lines":[39],"(NBAS-4,":[40],"-5,":[41],"and":[42,89,109],"-6)":[43],"yielded":[44],"nine":[45,65],"differentially":[46],"expressed":[47],"cDNAs":[48,75,126],"designated":[49],"NDDE:1-9,":[50],"for":[51,61,71],"MYCN-dependent":[52],"differential":[53],"genes.":[55],"GenBank":[57],"search":[58],"revealed":[59],"matches":[60],"seven":[62],"cDNAs.":[66],"confirmed":[70],"five":[72,125],"Northern":[77],"blot":[78],"analysis.":[79],"NDDE:8":[81],"up-regulated":[83,101],"in":[84,102,134],"clones":[88],"shares":[90,110],"homology":[91,111],"with":[92,112],"EB1":[94],"clone":[95],"p53-induced":[96],"gene":[97],"(PRG3).":[98],"NDDE:2":[99],"high-expressing":[104],"N-myc":[105],"protein":[106,118],"a":[113],"27":[114],"kD":[115],"heat":[116],"shock":[117],"PAN1":[119],"clone.":[120],"Further":[121],"analysis":[122],"all":[124],"might":[127],"further":[128],"elucidate":[129],"targets":[131],"NB.":[135]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}