{"id":"https://openalex.org/W2029508705","doi":"https://doi.org/10.1016/s0960-894x(00)00104-9","title":"Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands","display_name":"Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2029508705","doi":"https://doi.org/10.1016/s0960-894x(00)00104-9","mag":"2029508705","pmid":"https://pubmed.ncbi.nlm.nih.gov/10843203"},"language":"fi","primary_location":{"id":"doi:10.1016/s0960-894x(00)00104-9","doi":"https://doi.org/10.1016/s0960-894x(00)00104-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(00)00104-9","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000389847","display_name":"Michael H. Rabinowitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Rabinowitz","raw_affiliation_strings":["Glaxo Wellcome, Inc., Research Triangle Park, NC 27709, USA. mhr20812@glaxowellcome.com","GlaxoWellcome Inc., 5 Moore Drive, Research Triangle Park, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome, Inc., Research Triangle Park, NC 27709, USA. mhr20812@glaxowellcome.com","institution_ids":[]},{"raw_affiliation_string":"GlaxoWellcome Inc., 5 Moore Drive, Research Triangle Park, NC 27709, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070848001","display_name":"Pierfausto Seneci","orcid":"https://orcid.org/0000-0001-9709-7344","observed_orcids":["https://orcid.org/0000-0001-9709-7344"]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierfausto Seneci","raw_affiliation_strings":["GlaxoWellcome Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoWellcome Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006377505","display_name":"Tino Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tino Rossi","raw_affiliation_strings":["GlaxoWellcome Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoWellcome Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110320855","display_name":"Michele Dal Cin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Dal Cin","raw_affiliation_strings":["GlaxoWellcome Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoWellcome Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073939267","display_name":"Martyn J. Deal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martyn Deal","raw_affiliation_strings":["GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG11 2NY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG11 2NY, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017478342","display_name":"Georg C. Terstappen","orcid":"https://orcid.org/0000-0003-3669-0421","observed_orcids":["https://orcid.org/0000-0003-3669-0421"]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Georg Terstappen","raw_affiliation_strings":["GlaxoWellcome Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoWellcome Medicines Research Centre, Via Fleming 4, 37100 Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000389847"],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":3.3426,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.9253208,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"10","issue":"10","first_page":"1007","last_page":"1010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/combinatorial-synthesis","display_name":"combinatorial synthesis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8997005820274353},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.7047529816627502},{"id":"https://openalex.org/C2776469878","wikidata":"https://www.wikidata.org/wiki/Q2026994","display_name":"Solid-phase synthesis","level":3,"score":0.6770022511482239},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.6543768048286438},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.6406602263450623},{"id":"https://openalex.org/C81426234","wikidata":"https://www.wikidata.org/wiki/Q1408763","display_name":"Solid phase extraction","level":3,"score":0.6102625131607056},{"id":"https://openalex.org/C2994224535","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial synthesis","level":2,"score":0.5440106391906738},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5350841879844666},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5180840492248535},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.47603797912597656},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.4317170977592468},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.39175722002983093},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3697470426559448},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.1419960856437683},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13296377658843994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10167405009269714}],"mesh":[{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020104","descriptor_name":"Immunophilins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022021","descriptor_name":"Tacrolimus Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-894x(00)00104-9","doi":"https://doi.org/10.1016/s0960-894x(00)00104-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(00)00104-9","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:10843203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10843203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1614532287","https://openalex.org/W1982548738","https://openalex.org/W1998682872","https://openalex.org/W2003031313","https://openalex.org/W2020888003","https://openalex.org/W2035646551","https://openalex.org/W2036539375","https://openalex.org/W2042740099","https://openalex.org/W2051074466","https://openalex.org/W2067363171","https://openalex.org/W2078034391","https://openalex.org/W2080784258","https://openalex.org/W2137341857","https://openalex.org/W4238009417"],"related_works":["https://openalex.org/W4230116422","https://openalex.org/W1964186936","https://openalex.org/W2949871656","https://openalex.org/W2952113757","https://openalex.org/W1963666259","https://openalex.org/W1993350996","https://openalex.org/W4237275875","https://openalex.org/W2122549916","https://openalex.org/W2062015440","https://openalex.org/W2953333310"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}