{"id":"https://openalex.org/W202943630","doi":null,"title":"Guinea pig as an appropriate model for colonization of Helicobacter pylori.","display_name":"Guinea pig as an appropriate model for colonization of Helicobacter pylori.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W202943630","mag":"202943630"},"language":"en","primary_location":{"id":"mag:202943630","doi":null,"is_oa":false,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20133107198","pdf_url":null,"source":{"id":"https://openalex.org/S4306511636","display_name":"GOVARESH","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Govaresh","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009359992","display_name":"Parastoo Saniee","orcid":"https://orcid.org/0000-0003-1729-8256","observed_orcids":["https://orcid.org/0000-0003-1729-8256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Parastoo Saniee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1729-8256","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040518028","display_name":"Farideh Siavoshi","orcid":"https://orcid.org/0000-0002-6659-1160","observed_orcids":["https://orcid.org/0000-0002-6659-1160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farideh Siavoshi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6659-1160","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109116460","display_name":"Abdolfattah Sarrafnejad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdolfattah Sarrafnejad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103035996","display_name":"Maryam Kadivar","orcid":"https://orcid.org/0000-0003-3121-6747","observed_orcids":["https://orcid.org/0000-0003-3121-6747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maryam Kadivar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3121-6747","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111692737","display_name":"Sadegh Massarrat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadegh Massarrat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"4","first_page":"236","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":1.0},{"id":"https://openalex.org/keywords/guinea-pig-model","display_name":"guinea pig model","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bacterial-colonization","display_name":"bacterial colonization","score":0.7020000219345093},{"id":"https://openalex.org/keywords/experimental-infection","display_name":"experimental infection","score":0.6570000052452087},{"id":"https://openalex.org/keywords/16s-rrna-gene","display_name":"16S rRNA gene","score":0.7730000019073486},{"id":"https://openalex.org/keywords/stool-antigen-test","display_name":"stool antigen test","score":0.8799999952316284},{"id":"https://openalex.org/keywords/indirect-immunofluorescence","display_name":"indirect immunofluorescence","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gastritis","display_name":"gastritis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/gastric-histopathology","display_name":"gastric histopathology","score":0.8970000147819519},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7368634939193726},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6352628469467163},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5833957195281982},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.5635379552841187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5619189739227295},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.528319776058197},{"id":"https://openalex.org/C2776927270","wikidata":"https://www.wikidata.org/wiki/Q815962","display_name":"Colonization","level":2,"score":0.47424572706222534},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4694646894931793},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.454402893781662},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4341731071472168},{"id":"https://openalex.org/C98246554","wikidata":"https://www.wikidata.org/wiki/Q5280334","display_name":"Direct fluorescent antibody","level":3,"score":0.428592324256897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2890772223472595},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27946484088897705},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.27551448345184326},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:202943630","doi":null,"is_oa":false,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20133107198","pdf_url":null,"source":{"id":"https://openalex.org/S4306511636","display_name":"GOVARESH","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Govaresh","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1562505691","https://openalex.org/W1606980104","https://openalex.org/W1653820698","https://openalex.org/W1847769855","https://openalex.org/W1895526710","https://openalex.org/W1944708995","https://openalex.org/W1970766014","https://openalex.org/W1973951560","https://openalex.org/W1975756035","https://openalex.org/W1982371362","https://openalex.org/W1989014296","https://openalex.org/W1992945893","https://openalex.org/W1993552851","https://openalex.org/W2001678843","https://openalex.org/W2002664660","https://openalex.org/W2003419155","https://openalex.org/W2011422202","https://openalex.org/W2017132882","https://openalex.org/W2042577423","https://openalex.org/W2046454404","https://openalex.org/W2056697974","https://openalex.org/W2079418373","https://openalex.org/W2106748453","https://openalex.org/W2107078862","https://openalex.org/W2115805823","https://openalex.org/W2126499540","https://openalex.org/W2138094519","https://openalex.org/W2143630106","https://openalex.org/W2150143794","https://openalex.org/W2153354382","https://openalex.org/W2154611204","https://openalex.org/W2168416138","https://openalex.org/W2462080623"],"related_works":["https://openalex.org/W7095664059","https://openalex.org/W2380651360","https://openalex.org/W2441824875","https://openalex.org/W2150143794","https://openalex.org/W759652964","https://openalex.org/W1825016919","https://openalex.org/W1828503025","https://openalex.org/W2466523653","https://openalex.org/W2160416740","https://openalex.org/W2330457764"],"abstract_inverted_index":{"Background":[0],":":[1],"Animal":[5],"models":[6],"have":[7,297],"been":[8],"proven":[9],"useful":[10],"in":[11,24,51,196,210,230,246,275,289,318],"elucidating":[12],"the":[13,28,40,130,143,182,202,211,231,234,247,290,303,315,335,339,354,365],"details":[14],"of":[15,30,42,106,145,185,204,233,240,249,266,278,284,292,308,356,367],"interaction":[16],"between":[17],"pathogenic":[18],"bacteria":[19],"and":[20,33,63,134,158,221,243,254,273,333],"their":[21],"human":[22,316],"hosts,":[23],"addition":[25],"to":[26,139,314,352,363],"assessing":[27],"efficacy":[29,366],"therapeutic":[31],"compounds":[32],"vaccines.":[34,370],"In":[35],"this":[36],"study,":[37],"we":[38],"investigate":[39],"colonization":[41,283],"Helicobacter":[44],"pylori":[45,49,78,148,175,207,228,269,287,359],"(":[47],"H.":[48,77,147,174,206,227,268,286,358],")":[50],"experimentally-infected":[52],"guinea":[53,95,187,279,293,310,340],"pigs":[54,96,280],"over":[55],"a":[56,89,104,309,328],"six-month":[57],"period.":[58],"Materials":[62],"Methods:":[64],"A":[68],"bacterial":[69,101,304],"suspension":[70,102],"was":[71,112,179,193],"prepared":[72],"by":[73,302,324],"mixing":[74],"four":[75],"isolates":[80],"obtained":[81,151],"from":[82,152,181,213],"patients":[83],"diagnosed":[84],"with":[85,100,114],"gastric":[86],"ulcer.":[87],"Within":[88],"one":[90],"week":[91],"period,":[92],"five":[93,186,198,215],"female":[94],"were":[97,119,161],"dosed":[98],"orally":[99],"for":[103,124,142,163,349],"total":[105],"three":[107],"times.":[108],"One":[109],"control":[110,235],"animal":[111,347],"gavaged":[113],"normal":[115],"saline.":[116],"Stool":[117],"samples":[118,141,184,277],"collected":[120],"at":[121,156,252],"two-week":[122],"intervals":[123],"six":[125],"months.":[126],"We":[127,237],"used":[128],"PCR,":[129,217],"stool":[131,183,190,218,232,276],"antigen":[132,191,219],"test,":[133],"indirect":[135],"immunofluorescence":[136],"assay":[137],"(IFA)":[138],"assess":[140,364],"presence":[144,203],".":[149],"Stomachs":[150],"two":[153],"chloroform-killed":[154],"animals,":[155],"8":[157,253],"24":[159,255],"weeks,":[160],"investigated":[162],"histopathologic":[164],"changes.":[165],"Results:":[169],"16S":[177,271],"rDNA":[178,272],"amplified":[180],"pigs.":[188,294],"The":[189,264,306],"test":[192,220],"also":[194],"positive":[195],"all":[197,214],"animals.":[199,216],"IFA":[200,222],"demonstrated":[201,281],"antigens":[209,274],"stools":[212],"results":[223],"showed":[224],"no":[225],"animal.":[236],"observed":[238],"infiltration":[239],"mature":[241],"lymphocytes":[242],"plasma":[244],"cells":[245],"stomachs":[248,291],"animals":[250],"killed":[251],"weeks.":[256],"Conclusion:":[260],"occurrence":[265],"persistent":[282],"Histopathological":[295],"findings":[296],"confirmed":[298],"mild-severe":[299],"gastritis":[300],"induced":[301],"infection.":[305],"stomach":[307],"pig":[311,341],"is":[312,321],"similar":[313],"stomach,":[317],"that":[319],"it":[320],"sterile,":[322],"lined":[323],"glandular":[325],"epithelium,":[326],"lacks":[327],"vitamin":[329],"C":[330],"synthesizing":[331],"system":[332],"produces":[334],"cytokine":[336],"interleukin-8.":[337],"Accordingly,":[338],"can":[342],"be":[343],"considered":[344],"an":[345],"appropriate":[346],"model":[348],"long-term":[350],"experiments":[351],"follow":[353],"process":[355],"pathogenesis":[361],"or":[362,369],"antibiotics":[368]},"counts_by_year":[],"updated_date":"2026-07-23T06:02:39.697066","created_date":"2016-06-24T00:00:00"}