{"id":"https://openalex.org/W2029419974","doi":"https://doi.org/10.1074/jbc.m202558200","title":"Identification and Characterization of a Novel Secretory Granule Calcium-binding Protein from the Early Branching Eukaryote Giardia lamblia","display_name":"Identification and Characterization of a Novel Secretory Granule Calcium-binding Protein from the Early Branching Eukaryote Giardia lamblia","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2029419974","doi":"https://doi.org/10.1074/jbc.m202558200","mag":"2029419974","pmid":"https://pubmed.ncbi.nlm.nih.gov/12354777"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m202558200","doi":"https://doi.org/10.1074/jbc.m202558200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202558200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m202558200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010844369","display_name":"Maria Carolina Touz","orcid":"https://orcid.org/0000-0002-6769-6896","observed_orcids":["https://orcid.org/0000-0002-6769-6896"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I166401450","display_name":"Universidad Nacional de C\u00f3rdoba","ror":"https://ror.org/056tb7j80","country_code":"AR","type":"education","lineage":["https://openalex.org/I166401450"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Mar\u0131\u0301a C. Touz","raw_affiliation_strings":["Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, CP 5000 C\u00f3rdoba, Argentina","Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892","rdoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, CP 5000 C\u00f3rdoba, Argentina","institution_ids":["https://openalex.org/I166401450"]},{"raw_affiliation_string":"Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"rdoba, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055596256","display_name":"Natalia Gottig","orcid":"https://orcid.org/0000-0002-8730-8248","observed_orcids":["https://orcid.org/0000-0002-8730-8248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Gottig","raw_affiliation_strings":["rdoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"rdoba, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111722629","display_name":"Theodore E. Nash","orcid":"https://orcid.org/0000-0003-4619-0068","observed_orcids":["https://orcid.org/0000-0003-4619-0068"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore E. Nash","raw_affiliation_strings":["Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086191612","display_name":"Hugo Daniel Luj\u00e1n","orcid":"https://orcid.org/0000-0002-3797-8315","observed_orcids":["https://orcid.org/0000-0002-3797-8315"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hugo D. Lujan","raw_affiliation_strings":["rdoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"rdoba, Argentina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086191612"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.151,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.90279236,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"277","issue":"52","first_page":"50557","last_page":"50563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.11379999667406082,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/giardia-duodenalis","display_name":"Giardia lamblia","score":1.0},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/secretory-vesicles","display_name":"secretory vesicles","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cyst-wall-proteins","display_name":"cyst wall proteins","score":0.9190000295639038},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/calcium-sequestration","display_name":"calcium sequestration","score":0.6830000281333923},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.46700000762939453},{"id":"https://openalex.org/keywords/cyst-wall-formation","display_name":"cyst wall formation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/protein-maturation","display_name":"protein maturation","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2780626423","wikidata":"https://www.wikidata.org/wiki/Q155630","display_name":"Giardia lamblia","level":2,"score":0.903023362159729},{"id":"https://openalex.org/C2779413310","wikidata":"https://www.wikidata.org/wiki/Q19088","display_name":"Eukaryote","level":4,"score":0.8413749933242798},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.5931644439697266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48555251955986023},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4756072163581848},{"id":"https://openalex.org/C122229402","wikidata":"https://www.wikidata.org/wiki/Q5018802","display_name":"Calcium-binding protein","level":3,"score":0.42355674505233765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3844241201877594},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3624265193939209},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3251860737800598},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30247199535369873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23885467648506165},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0702214241027832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016829","descriptor_name":"Giardia lamblia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016829","descriptor_name":"Giardia lamblia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022142","descriptor_name":"Secretory Vesicles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022142","descriptor_name":"Secretory Vesicles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m202558200","doi":"https://doi.org/10.1074/jbc.m202558200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202558200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12354777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12354777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"doi:10.60692/c2qqh-7qd79","doi":"https://doi.org/10.60692/c2qqh-7qd79","is_oa":true,"landing_page_url":"https://doi.org/10.60692/c2qqh-7qd79","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/eye5x-ae260","doi":"https://doi.org/10.60692/eye5x-ae260","is_oa":true,"landing_page_url":"https://doi.org/10.60692/eye5x-ae260","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1074/jbc.m202558200","doi":"https://doi.org/10.1074/jbc.m202558200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202558200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W228140831","https://openalex.org/W1494127461","https://openalex.org/W1511284320","https://openalex.org/W1570678799","https://openalex.org/W1590925313","https://openalex.org/W1638182766","https://openalex.org/W1943240551","https://openalex.org/W1949772429","https://openalex.org/W1962379686","https://openalex.org/W1964137284","https://openalex.org/W1965233966","https://openalex.org/W1967711037","https://openalex.org/W1972510078","https://openalex.org/W1981430103","https://openalex.org/W1983785927","https://openalex.org/W1990895654","https://openalex.org/W1993418465","https://openalex.org/W2003196036","https://openalex.org/W2010276117","https://openalex.org/W2012071086","https://openalex.org/W2013890507","https://openalex.org/W2014453656","https://openalex.org/W2015644766","https://openalex.org/W2022743955","https://openalex.org/W2030823707","https://openalex.org/W2035347592","https://openalex.org/W2039075759","https://openalex.org/W2040080546","https://openalex.org/W2048038925","https://openalex.org/W2050638929","https://openalex.org/W2053168795","https://openalex.org/W2054474302","https://openalex.org/W2054511977","https://openalex.org/W2059717849","https://openalex.org/W2076373695","https://openalex.org/W2077764934","https://openalex.org/W2085820872","https://openalex.org/W2086145483","https://openalex.org/W2088182007","https://openalex.org/W2088831160","https://openalex.org/W2089664625","https://openalex.org/W2089807533","https://openalex.org/W2095224851","https://openalex.org/W2102424043","https://openalex.org/W2105236798","https://openalex.org/W2123065833","https://openalex.org/W2128270335","https://openalex.org/W2129929437","https://openalex.org/W2135290865","https://openalex.org/W2138755616","https://openalex.org/W2139786644","https://openalex.org/W2144190351","https://openalex.org/W2144634347","https://openalex.org/W2153431707","https://openalex.org/W2154472809","https://openalex.org/W2155642878","https://openalex.org/W2158714788","https://openalex.org/W2164217851","https://openalex.org/W2171091522","https://openalex.org/W2185936454","https://openalex.org/W2314225431","https://openalex.org/W2315577485","https://openalex.org/W4251949382"],"related_works":["https://openalex.org/W2015223879","https://openalex.org/W1943240551","https://openalex.org/W2065714762","https://openalex.org/W2398575617","https://openalex.org/W2040080546","https://openalex.org/W2013108869","https://openalex.org/W7100681132","https://openalex.org/W6940174103","https://openalex.org/W3157980990","https://openalex.org/W168985028"],"abstract_inverted_index":{"Giardia":[0,20],"lamblia":[1,199],"is":[2,43,127,167],"a":[3,96,108,157,192],"flagellate":[4],"protozoan":[5],"that":[6,73,156,161,231],"infects":[7],"humans":[8],"and":[9,12,58,82,137,179],"other":[10,206],"mammals":[11],"the":[13,29,47,61,64,77,87,112,119,123,130,144,147,165],"most":[14,48],"frequently":[15],"isolated":[16],"intestinal":[17],"parasite":[18,65],"worldwide.":[19],"trophozoites":[21],"undergo":[22],"essential":[23],"biological":[24],"changes":[25],"to":[26,86,164,172,181,204],"survive":[27],"outside":[28],"intestine":[30],"of":[31,46,63,122,146,216,219,223,239],"their":[32],"host":[33],"by":[34,53,95],"differentiating":[35],"into":[36,76],"infective":[37],"cysts.":[38],"Cyst":[39,101],"formation,":[40,229],"or":[41],"encystation,":[42],"considered":[44],"one":[45],"primitive":[49],"adaptive":[50],"responses":[51],"developed":[52],"eukaryotes":[54],"early":[55],"in":[56,134,139,184,209],"evolution":[57],"crucial":[59],"for":[60,197],"transmission":[62],"among":[66],"susceptible":[67],"hosts.":[68],"During":[69],"this":[70,151,189,232],"process,":[71],"proteins":[72,103],"will":[74],"assemble":[75],"extracellular":[78,148],"cyst":[79,124,227,242],"wall":[80,102,228,243],"(CWP1":[81],"CWP2)":[83],"are":[84,105],"transported":[85],"cell":[88],"surface":[89],"within":[90],"encystation-specific":[91],"secretory":[92,99,233],"vesicles":[93],"(ESVs)":[94],"developmentally":[97],"regulated":[98],"pathway.":[100],"(CWPs)":[104],"maintained":[106],"as":[107,141,143],"dense":[109],"material":[110],"inside":[111],"ESVs,":[113],"but":[114],"after":[115],"exocytosis,":[116],"they":[117],"form":[118],"fibrillar":[120],"matrix":[121],"wall.":[125,149],"Little":[126],"known":[128],"about":[129],"molecular":[131],"mechanisms":[132],"involved":[133],"granule":[135,177,234],"biogenesis":[136],"discharge":[138],"Giardia,":[140],"well":[142],"assembly":[145],"In":[150],"work,":[152],"we":[153],"provide":[154],"evidences":[155],"novel":[158,193],"54-kDa":[159],"protein":[160,194,207,235],"exclusively":[162],"localizes":[163],"ESVs":[166,240],"induced":[168],"during":[169,176,241],"encystation":[170],"similar":[171],"CWPs,":[173],"proteolytically":[174],"processed":[175],"maturation,":[178],"able":[180],"bind":[182],"calcium":[183],"vitro.":[185],"The":[186],"gene":[187],"encoding":[188],"molecule":[190],"predicts":[191],"(called":[195],"gGSP":[196,224],"G.":[198],"Granule-specific":[200],"Protein)":[201],"without":[202],"homology":[203],"any":[205],"reported":[208],"public":[210],"databases.":[211],"Nevertheless,":[212],"it":[213],"possesses":[214],"characteristics":[215],"calcium-sequestering":[217],"molecules":[218],"higher":[220],"eukaryotes.":[221],"Inhibition":[222],"expression":[225],"abolishes":[226],"suggesting":[230],"regulates":[236],"Ca(2+)-dependent":[237],"degranulation":[238],"formation.":[244]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}