{"id":"https://openalex.org/W2029377385","doi":"https://doi.org/10.1073/pnas.0909314107","title":"PI3 kinase signaling is involved in A\u03b2-induced memory loss in Drosophila","display_name":"PI3 kinase signaling is involved in A\u03b2-induced memory loss in Drosophila","publication_year":2010,"publication_date":"2010-03-29","ids":{"openalex":"https://openalex.org/W2029377385","doi":"https://doi.org/10.1073/pnas.0909314107","mag":"2029377385","pmid":"https://pubmed.ncbi.nlm.nih.gov/20351282","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872421"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0909314107","doi":"https://doi.org/10.1073/pnas.0909314107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0909314107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872421","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026318194","display_name":"Hsueh\u2010Cheng Chiang","orcid":"https://orcid.org/0000-0001-9607-7835","observed_orcids":["https://orcid.org/0000-0001-9607-7835"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsueh-Cheng Chiang","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;","Department of Neuroscience, State University of New York, Stony Brook, NY 11794;","Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"Department of Neuroscience, State University of New York, Stony Brook, NY 11794;","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436146","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0003-3870-3388","observed_orcids":["https://orcid.org/0000-0003-3870-3388"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China; and","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010883669","display_name":"Zuolei Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuolei Xie","raw_affiliation_strings":["JoeKai, Inc., Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JoeKai, Inc., Beijing 100084, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alice Yau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Yau","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;","#N##TAB##TAB##TAB##TAB# Cold Spring Harbor Laboratory#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Cold Spring Harbor Laboratory#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049412020","display_name":"Yi Zhong","orcid":"https://orcid.org/0000-0002-7927-5976","observed_orcids":["https://orcid.org/0000-0002-7927-5976","https://orcid.org/0009-0005-1917-9631","https://orcid.org/0009-0006-4498-1391","https://orcid.org/0000-0002-4652-7241","https://orcid.org/0000-0002-9177-1278"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yi Zhong","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;","Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China; and","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7133,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.90166628,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"107","issue":"15","first_page":"7060","last_page":"7065"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7509999871253967},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8050000071525574},{"id":"https://openalex.org/keywords/memory-loss","display_name":"memory loss","score":0.8690000176429749},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.8270000219345093},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pi3k-inhibition","display_name":"PI3K inhibition","score":0.8709999918937683},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7893427610397339},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5262203216552734},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5225985646247864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5094926953315735},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4921185374259949},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4564741253852844},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4462416172027588},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4427527189254761},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4300929009914398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2233218252658844},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11041095852851868}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012903","descriptor_name":"Smell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.0909314107","doi":"https://doi.org/10.1073/pnas.0909314107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0909314107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2872421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20351282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20351282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:repository.cshl.edu:15385","doi":null,"is_oa":true,"landing_page_url":"https://repository.cshl.edu/id/eprint/15385/1/Zhong%20PNAS%202010.pdf","pdf_url":"http://repository.cshl.edu/15385/1/Zhong%20PNAS%202010.pdf","source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Paper"},{"id":"mag:2798871447","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/25665302","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2872421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G280594550","display_name":null,"funder_award_id":"2R01 NS34779-06","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6662269635","display_name":"DROSOPHILA MODELS FOR STUDYING FUNCTION OF THE NF1 GENE","funder_award_id":"R01NS034779","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2029377385.pdf","grobid_xml":"https://content.openalex.org/works/W2029377385.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1921832013","https://openalex.org/W1926996067","https://openalex.org/W1969302633","https://openalex.org/W1972188808","https://openalex.org/W1972875881","https://openalex.org/W1980825524","https://openalex.org/W1987416014","https://openalex.org/W1992869587","https://openalex.org/W1995413041","https://openalex.org/W2001560475","https://openalex.org/W2025833425","https://openalex.org/W2030425436","https://openalex.org/W2040949523","https://openalex.org/W2043865307","https://openalex.org/W2047509507","https://openalex.org/W2048847028","https://openalex.org/W2053964608","https://openalex.org/W2072381888","https://openalex.org/W2075481535","https://openalex.org/W2077009055","https://openalex.org/W2088730774","https://openalex.org/W2088782756","https://openalex.org/W2095220111","https://openalex.org/W2101746871","https://openalex.org/W2108498652","https://openalex.org/W2109727228","https://openalex.org/W2117141439","https://openalex.org/W2126584236","https://openalex.org/W2129645512","https://openalex.org/W2131760568","https://openalex.org/W2131819352","https://openalex.org/W2135843883","https://openalex.org/W2136740555","https://openalex.org/W2146188406","https://openalex.org/W2147231139","https://openalex.org/W2149675711","https://openalex.org/W2150999725","https://openalex.org/W2173497794"],"related_works":["https://openalex.org/W2798871447","https://openalex.org/W2996877320","https://openalex.org/W2015048951","https://openalex.org/W2092719335","https://openalex.org/W1833705267","https://openalex.org/W2018729945","https://openalex.org/W3181317812","https://openalex.org/W1485047132","https://openalex.org/W2988564726","https://openalex.org/W6956411"],"abstract_inverted_index":{"Multiple":[0],"intracellular":[1],"signals":[2],"are":[3],"altered":[4],"in":[5,38,51,57,79,163,168,173],"Alzheimer's":[6,52],"disease":[7,53],"brain":[8],"tissues,":[9],"including":[10],"the":[11,15,35,43,66,73,80,88,127,136],"PI3K/Akt":[12],"pathway.":[13],"However,":[14],"pathological":[16],"relevance":[17],"of":[18,42,65,72,91,99,115,126,152,175],"such":[19],"alterations":[20],"is":[21,49,107,121],"poorly":[22],"understood.":[23],"In":[24],"vitro":[25],"studies":[26],"yield":[27],"results":[28],"that":[29,63,104,139,158],"seem":[30],"to":[31,70,109,135],"be":[32,144],"consistent":[33],"with":[34,170],"conventional":[36],"perception":[37],"which":[39,162],"an":[40,171],"up-regulation":[41],"cell":[44],"survival":[45],"pathway,":[46,48],"PI3K":[47,67,116,119,128,153],"protective":[50],"pathogenesis.":[54],"The":[55],"current":[56],"vivo":[58],"genetic":[59,147],"approach,":[60],"however,":[61],"reveals":[62],"inhibition":[64,114,151],"pathway":[68],"leads":[69],"rescuing":[71],"beta-amyloid":[74],"peptide":[75],"(Abeta)-induced":[76],"memory":[77,93,141,166],"loss":[78,94,142,167],"Drosophila":[81],"brain.":[82],"We":[83,102],"began":[84],"our":[85],"inquiry":[86],"into":[87],"molecular":[89],"basis":[90],"this":[92],"by":[95,124],"studying":[96],"Abeta42-induced":[97,118,140],"enhancement":[98],"long-term":[100,105],"depression.":[101],"found":[103],"depression":[106],"restored":[108],"a":[110],"normal":[111],"level":[112],"through":[113,146],"activity.":[117],"hyperactivity":[120],"directly":[122],"confirmed":[123],"immunostaining":[125],"phosphorylation":[129],"targets,":[130],"phospholipids.":[131],"Such":[132],"observations":[133],"lead":[134],"following":[137],"demonstration":[138],"can":[143],"rescued":[145],"silencing":[148],"or":[149],"pharmacological":[150],"functions.":[154],"Our":[155],"data":[156],"suggest":[157],"Abeta42":[159,176],"stimulates":[160],"PI3K,":[161],"turn":[164],"causes":[165],"association":[169],"increase":[172],"accumulation":[174],"aggregates.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
