{"id":"https://openalex.org/W202937464","doi":"https://doi.org/10.18632/aging.100337","title":"Human embryo stem cells and DNA repair","display_name":"Human embryo stem cells and DNA repair","publication_year":2011,"publication_date":"2011-06-09","ids":{"openalex":"https://openalex.org/W202937464","doi":"https://doi.org/10.18632/aging.100337","mag":"202937464","pmid":"https://pubmed.ncbi.nlm.nih.gov/21685511","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3164364"},"language":"en","primary_location":{"id":"doi:10.18632/aging.100337","doi":"https://doi.org/10.18632/aging.100337","is_oa":false,"landing_page_url":"http://doi.org/10.18632/aging.100337","pdf_url":null,"source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3164364","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055277438","display_name":"Marco Durante","orcid":"https://orcid.org/0000-0002-4615-553X","observed_orcids":["https://orcid.org/0000-0002-4615-553X"]},"institutions":[{"id":"https://openalex.org/I169556180","display_name":"GSI Helmholtz Centre for Heavy Ion Research","ror":"https://ror.org/02k8cbn47","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I169556180"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marco Durante","raw_affiliation_strings":["GSII Helmholtzzentrum f\u00fcr Schwerionenforschung, Planckstra\u03b2e 1, Darmstadt 64291, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSII Helmholtzzentrum f\u00fcr Schwerionenforschung, Planckstra\u03b2e 1, Darmstadt 64291, Germany","institution_ids":["https://openalex.org/I169556180"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055277438"],"corresponding_institution_ids":["https://openalex.org/I169556180"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"6","first_page":"564","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9879999756813049},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.902999997138977},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9229999780654907},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9509999752044678},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.843999981880188},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.9100000262260437},{"id":"https://openalex.org/keywords/g1-phase","display_name":"G1 phase","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6240745186805725},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5708381533622742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5237241387367249},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44318950176239014},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4160705506801605},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.41115012764930725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3710462749004364},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3420279324054718}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.18632/aging.100337","doi":"https://doi.org/10.18632/aging.100337","is_oa":false,"landing_page_url":"http://doi.org/10.18632/aging.100337","pdf_url":null,"source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3164364","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3164364","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:21685511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21685511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Comment"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.5811","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.5811","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/93/13/Aging_(Albany_NY)_2011_Jun_9_3(6)_564.tar.gz","raw_type":"text"},{"id":"pmh:oai:repository.gsi.de:186596","doi":null,"is_oa":false,"landing_page_url":"http://repository.gsi.de/search?p=id:%22GSI-2016-01094%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401977","display_name":"GSI Repository (German Federal Government)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging 3(6), 564 (2011).","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.gsi.de:48316","doi":null,"is_oa":false,"landing_page_url":"https://repository.gsi.de/record/48316","pdf_url":null,"source":{"id":"https://openalex.org/S4306401977","display_name":"GSI Repository (German Federal Government)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging 3(6), 564 (2011).","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3164364","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3164364","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1269552450","https://openalex.org/W2030739911","https://openalex.org/W2079853060","https://openalex.org/W2086943348","https://openalex.org/W2086997734","https://openalex.org/W2151565099"],"related_works":["https://openalex.org/W7037346476","https://openalex.org/W2080274817","https://openalex.org/W2511351127","https://openalex.org/W2049217916","https://openalex.org/W1269552450","https://openalex.org/W2487376052","https://openalex.org/W2053549853","https://openalex.org/W62672690","https://openalex.org/W2033411843","https://openalex.org/W2162085319"],"abstract_inverted_index":{"Pluripotent":[0],"human":[1],"embryonic":[2],"stem":[3],"cells":[4,119],"(hESCs)":[5],"are":[6,114],"able":[7],"to":[8,23],"differentiate":[9],"in":[10,33,78,108,120],"all":[11,18],"different":[12],"specialized":[13],"tissues":[14],"[1].":[15],"Yet,":[16],"as":[17],"living":[19],"cells,":[20],"they":[21],"have":[22,99],"cope":[24],"with":[25],"endogenous":[26],"or":[27],"exogenous":[28],"DNA":[29,34,121],"damage.":[30],"Their":[31],"efficacy":[32],"repair":[35,51,67],"is":[36],"somewhat":[37],"controversial.":[38],"Clearly":[39],"hESCs":[40,79],"can":[41,104],"achieve":[42],"the":[43,54,72,94],"indispensable":[44],"genome":[45],"stability":[46],"either":[47],"by":[48,56],"more":[49,115],"effective":[50],"or,":[52],"on":[53],"contrary,":[55],"increasing":[57],"apoptosis":[58],"thus":[59],"eliminating":[60],"defective":[61],"cells.":[62],"Previous":[63],"papers":[64],"reported":[65],"increased":[66],"efficiency":[68],"and":[69,82,103],"involvement":[70],"of":[71,84,110],"errorfree":[73],"homologous":[74],"recombination":[75],"(HR)":[76],"pathway":[77],"[2,":[80],"3],":[81],"use":[83,106],"high-fidelity,":[85],"ATM-independent":[86],"nonhomologous":[87],"end-joining":[88],"(NHEJ)":[89],"[4].":[90],"Those":[91],"results":[92],"support":[93],"hypothesis":[95],"that":[96],"hESCs,":[97],"which":[98],"a":[100],"short":[101],"G1-phase":[102],"then":[105],"HR":[107],"most":[109],"their":[111],"cell-cycle":[112],"[4]":[113],"efficient":[116],"than":[117],"somatic":[118],"double-strand":[122],"break":[123],"(DSBs)":[124],"repair.":[125]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
