{"id":"https://openalex.org/W2029345398","doi":"https://doi.org/10.1371/journal.pone.0021319","title":"Role of TMPRSS2-ERG Gene Fusion in Negative Regulation of PSMA Expression","display_name":"Role of TMPRSS2-ERG Gene Fusion in Negative Regulation of PSMA Expression","publication_year":2011,"publication_date":"2011-06-24","ids":{"openalex":"https://openalex.org/W2029345398","doi":"https://doi.org/10.1371/journal.pone.0021319","mag":"2029345398","pmid":"https://pubmed.ncbi.nlm.nih.gov/21731703","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123299"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0021319","doi":"https://doi.org/10.1371/journal.pone.0021319","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021319","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021319&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021319&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110329935","display_name":"Lihong Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihong Yin","raw_affiliation_strings":["Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102449435","display_name":"Pravin Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405285950","display_name":"Glickman Urological Institute","ror":"https://ror.org/00rxngd38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405285950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pravin Rao","raw_affiliation_strings":["Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405285950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111957341","display_name":"Paul J. Elson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Elson","raw_affiliation_strings":["Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101961991","display_name":"Jianghua Wang","orcid":"https://orcid.org/0000-0003-3532-3769","observed_orcids":["https://orcid.org/0000-0003-3532-3769"]},"institutions":[{"id":"https://openalex.org/I1299501804","display_name":"Michael E. DeBakey VA Medical Center","ror":"https://ror.org/052qqbc08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299501804","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianghua Wang","raw_affiliation_strings":["Department of Pathology and Immunology, Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center (VAMC), Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center (VAMC), Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1299501804","https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066263660","display_name":"Michael Ittmann","orcid":"https://orcid.org/0000-0003-4802-0978","observed_orcids":["https://orcid.org/0000-0003-4802-0978"]},"institutions":[{"id":"https://openalex.org/I1299501804","display_name":"Michael E. DeBakey VA Medical Center","ror":"https://ror.org/052qqbc08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299501804","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Ittmann","raw_affiliation_strings":["Department of Pathology and Immunology, Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center (VAMC), Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center (VAMC), Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1299501804","https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108357558","display_name":"Warren D.W. Heston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405285950","display_name":"Glickman Urological Institute","ror":"https://ror.org/00rxngd38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405285950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Warren D. W. Heston","raw_affiliation_strings":["Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, United States of America","Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405285950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108357558"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405285950"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.3893,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.80618479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"6","first_page":"e21319","last_page":"e21319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tmprss2-erg-fusion","display_name":"TMPRSS2-ERG fusion","score":0.9610000252723694},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.9710000157356262},{"id":"https://openalex.org/keywords/androgen-receptor-signaling","display_name":"androgen receptor signaling","score":0.640999972820282},{"id":"https://openalex.org/keywords/androgen-stimulation","display_name":"androgen stimulation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7720000147819519},{"id":"https://openalex.org/keywords/erg","display_name":"ERG","score":0.6079999804496765},{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/vcap-cells","display_name":"VCaP cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/flutamide","display_name":"flutamide","score":0.9480000138282776},{"id":"https://openalex.org/keywords/r1881","display_name":"R1881","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2778042024","wikidata":"https://www.wikidata.org/wiki/Q18032025","display_name":"TMPRSS2","level":5,"score":0.9629496932029724},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8022363185882568},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.7248099446296692},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5531522035598755},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.48565423488616943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4714813232421875},{"id":"https://openalex.org/C103796816","wikidata":"https://www.wikidata.org/wiki/Q185153","display_name":"Erg","level":3,"score":0.45913416147232056},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4569670557975769},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4372327923774719},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.43258580565452576},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4219207167625427},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3317691385746002},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2526450753211975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22530490159988403},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1728110909461975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15882116556167603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13221541047096252},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09436458349227905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05768159031867981},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.041297584772109985},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015741","descriptor_name":"Metribolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050939","descriptor_name":"Gene Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0021319","doi":"https://doi.org/10.1371/journal.pone.0021319","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021319","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021319&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2139630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123299","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3123299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21731703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21731703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.793.2627","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.793.2627","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7b/98/pone.0021319.PMC3123299.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f24ea26601104012a03f439d93a93088","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f24ea26601104012a03f439d93a93088","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 6, p e21319 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0021319","doi":"https://doi.org/10.1371/journal.pone.0021319","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021319","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021319&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2242330843","display_name":"PSMA, a Nutritional Target for Prostate Cancer Prevention","funder_award_id":"R01CA101069","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338485","display_name":"DOD Prostate Cancer Research Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2029345398.pdf","grobid_xml":"https://content.openalex.org/works/W2029345398.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1523096697","https://openalex.org/W1558144205","https://openalex.org/W1849365998","https://openalex.org/W1968405341","https://openalex.org/W1977388865","https://openalex.org/W1977550629","https://openalex.org/W1983011005","https://openalex.org/W1985307249","https://openalex.org/W2006508473","https://openalex.org/W2006619657","https://openalex.org/W2015437876","https://openalex.org/W2016973566","https://openalex.org/W2049205984","https://openalex.org/W2061891797","https://openalex.org/W2064293531","https://openalex.org/W2072451168","https://openalex.org/W2073038515","https://openalex.org/W2079298594","https://openalex.org/W2082462837","https://openalex.org/W2087207490","https://openalex.org/W2096800294","https://openalex.org/W2097226696","https://openalex.org/W2097629605","https://openalex.org/W2101103881","https://openalex.org/W2119752676","https://openalex.org/W2121158863","https://openalex.org/W2123985787","https://openalex.org/W2129583552","https://openalex.org/W2131456094","https://openalex.org/W2133328863","https://openalex.org/W2134247556","https://openalex.org/W2160671186"],"related_works":["https://openalex.org/W2314575732","https://openalex.org/W2064221081","https://openalex.org/W2049198834","https://openalex.org/W2118672983","https://openalex.org/W2073945055","https://openalex.org/W2069720660","https://openalex.org/W2141077390","https://openalex.org/W2133328863","https://openalex.org/W2409919698","https://openalex.org/W2015437876"],"abstract_inverted_index":{"Prostate":[0],"specific":[1],"membrane":[2],"antigen":[3],"(PSMA)":[4],"is":[5,14,22,34,64],"overexpressed":[6],"in":[7,29,41,53,109,118,127,140,149,156,168,174,212],"prostatic":[8],"adenocarcinoma":[9],"(CaP),":[10],"and":[11,91,159],"its":[12],"expression":[13,48,69,139,154],"negatively":[15],"regulated":[16,72],"by":[17,73,147,219],"androgen":[18,102,133,163],"stimulation.":[19],"However,":[20],"it":[21,122],"still":[23],"unclear":[24],"which":[25,87,94],"factors":[26],"are":[27],"involved":[28],"this":[30,62],"downregulation.":[31],"TMPRSS2-ERG":[32,51,75,89,104,166,195,220],"fusion":[33,52,54,196],"the":[35,50,74,96,132,157,175,202],"most":[36],"common":[37],"known":[38],"gene":[39,76,221],"rearrangement":[40],"prostate":[42,56],"carcinoma.":[43],"Androgen":[44],"stimulation":[45],"can":[46,70,197],"increase":[47],"of":[49,61,101,161,179,210],"positive":[55,82],"cancer":[57],"cells.":[58,111,129,143],"The":[59],"purpose":[60],"investigation":[63],"to":[65],"determine":[66],"whether":[67],"PSMA":[68,81,112,138,153,172,199,211],"be":[71],"fusion.":[77,97,222],"We":[78],"employed":[79],"two":[80],"cell":[83],"lines:":[84],"VCaP":[85,110,119,142,150,214],"cells,":[86,93,120],"harbor":[88],"fusion,":[90],"LNCaP":[92,128,169],"lack":[95],"After":[98],"24":[99],"hours":[100],"treatment,":[103],"mRNA":[105,113],"level":[106,114],"was":[107,115],"increased":[108],"dramatically":[116],"decreased":[117],"while":[121,181],"only":[123],"has":[124],"moderate":[125],"change":[126],"Treatment":[130],"with":[131],"antagonist":[134],"flutamide":[135],"partially":[136,217],"restored":[137],"androgen-treated":[141,213],"Knocking":[144],"down":[145],"ERG":[146,185],"siRNA":[148],"cells":[151,170,215],"enhances":[152],"both":[155,173],"presence":[158,176],"absence":[160,178],"synthetic":[162],"R1881.":[164],"Overexpressing":[165],"fusions":[167],"downregulated":[171],"or":[177],"R1881,":[180],"overexpressing":[182],"wild":[183],"type":[184],"did":[186],"not.":[187],"Using":[188],"PSMA-based":[189],"luciferase":[190],"reporter":[191],"assays,":[192],"we":[193],"found":[194],"inhibit":[198],"activity":[200],"at":[201],"transcriptional":[203],"level.":[204],"Our":[205],"data":[206],"indicated":[207],"that":[208],"downregulation":[209],"appears":[216],"mediated":[218]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
