{"id":"https://openalex.org/W2029329604","doi":"https://doi.org/10.1210/endo.139.3.5839","title":"Telomerase Activity in Normal Adult Brown Norway Rat Seminal Vesicle: Regional Distribution and Age-Dependent Changes","display_name":"Telomerase Activity in Normal Adult Brown Norway Rat Seminal Vesicle: Regional Distribution and Age-Dependent Changes","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W2029329604","doi":"https://doi.org/10.1210/endo.139.3.5839","mag":"2029329604","pmid":"https://pubmed.ncbi.nlm.nih.gov/9492040"},"language":"en","primary_location":{"id":"doi:10.1210/endo.139.3.5839","doi":"https://doi.org/10.1210/endo.139.3.5839","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.139.3.5839","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102004613","display_name":"Partha P. Banerjee","orcid":"https://orcid.org/0000-0001-9544-5640","observed_orcids":["https://orcid.org/0000-0001-9544-5640"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Partha P. Banerjee","raw_affiliation_strings":["Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111930336","display_name":"Subhadra Banerjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subhadra Banerjee","raw_affiliation_strings":["Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113501997","display_name":"Barry R. Zirkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry R. Zirkin","raw_affiliation_strings":["Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112858789","display_name":"Terry R. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry R. Brown","raw_affiliation_strings":["Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.3234,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.48937206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"139","issue":"3","first_page":"1075","last_page":"1081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/seminal-vesicle","display_name":"seminal vesicle","score":0.996999979019165},{"id":"https://openalex.org/keywords/brown-norway-rats","display_name":"Brown Norway rats","score":0.8880000114440918},{"id":"https://openalex.org/keywords/regional-distribution","display_name":"regional distribution","score":0.8370000123977661},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/telomeric-repeat-amplification-protocol","display_name":"telomeric repeat amplification protocol","score":0.7799999713897705},{"id":"https://openalex.org/keywords/seminal-vesicle-secretion","display_name":"seminal vesicle fluid","score":0.8330000042915344},{"id":"https://openalex.org/keywords/androgen-replacement","display_name":"androgen replacement","score":0.722000002861023},{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.7979999780654907},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.7289999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9290632009506226},{"id":"https://openalex.org/C2781171107","wikidata":"https://www.wikidata.org/wiki/Q217259","display_name":"Seminal vesicle","level":4,"score":0.8911662101745605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7332543134689331},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.6706668138504028},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5812457203865051},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5245571136474609},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5192151665687561},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.49187350273132324},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4254891276359558},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40211808681488037},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3224484622478485},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.2631446123123169},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11354359984397888},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08781391382217407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06525638699531555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012669","descriptor_name":"Seminal Vesicles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/endo.139.3.5839","doi":"https://doi.org/10.1210/endo.139.3.5839","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.139.3.5839","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/en.139.3.1075","doi":"https://doi.org/10.1210/en.139.3.1075","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.139.3.1075","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:9492040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9492040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5883103850","display_name":"AGING AND MALE REPRODUCTIVE TRACT STRUCTURE/FUNCTION","funder_award_id":"P01AG008321","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W178736140","https://openalex.org/W183820920","https://openalex.org/W1516272650","https://openalex.org/W1540861788","https://openalex.org/W1543500873","https://openalex.org/W1613006671","https://openalex.org/W1655330976","https://openalex.org/W1972303536","https://openalex.org/W1975718597","https://openalex.org/W1979314408","https://openalex.org/W1983673827","https://openalex.org/W1995250048","https://openalex.org/W1996384141","https://openalex.org/W1998663807","https://openalex.org/W2000971601","https://openalex.org/W2005356516","https://openalex.org/W2010474967","https://openalex.org/W2014231393","https://openalex.org/W2015037479","https://openalex.org/W2021758398","https://openalex.org/W2022507419","https://openalex.org/W2029675195","https://openalex.org/W2036189250","https://openalex.org/W2037749974","https://openalex.org/W2045702252","https://openalex.org/W2046651431","https://openalex.org/W2050275508","https://openalex.org/W2058197513","https://openalex.org/W2062086731","https://openalex.org/W2064208421","https://openalex.org/W2077449437","https://openalex.org/W2078484854","https://openalex.org/W2078786713","https://openalex.org/W2082682054","https://openalex.org/W2122740168","https://openalex.org/W2128635872","https://openalex.org/W2134532805","https://openalex.org/W2143063758","https://openalex.org/W2148805136","https://openalex.org/W2309542863","https://openalex.org/W2410259601","https://openalex.org/W3216099233","https://openalex.org/W6607188092"],"related_works":["https://openalex.org/W2082682054","https://openalex.org/W4239954929","https://openalex.org/W7044570407","https://openalex.org/W2078484854","https://openalex.org/W2101325274","https://openalex.org/W7097076056","https://openalex.org/W2334827502","https://openalex.org/W2085805978","https://openalex.org/W2107232580","https://openalex.org/W2127037617"],"abstract_inverted_index":{"Telomerase":[0],"activity":[1,124,134,155,183],"is":[2,92,171,192,210,222],"essential":[3],"for":[4,173,213],"protection":[5],"of":[6,17,32,56,87,150,202,219],"cells":[7,46,88,221],"against":[8],"the":[9,28,60,66,69,74,95,139,148,174,185,196,203,211,214,225,237],"telomere":[10],"erosion":[11],"that":[12,47,84,132,170,181,208],"occurs":[13],"with":[14,89,189],"each":[15],"round":[16],"cell":[18,63,249],"replication,":[19],"and":[20,53,191,199,230],"thus":[21],"appears":[22],"to":[23,76,121,166,239,243],"play":[24],"a":[25,49,85,108,217],"role":[26],"in":[27,94,125,138,147,184,241],"indefinite":[29],"replication":[30],"potential":[31,91,238],"some,":[33],"but":[34,145],"not":[35],"all,":[36],"eukaryotic":[37],"cells.":[38],"In":[39,103,159,177],"this":[40,104,232],"regard,":[41],"some":[42,168],"tissues":[43],"contain":[44,167],"stem":[45],"have":[48],"long":[50],"proliferative":[51],"life-span":[52],"are":[54],"capable":[55],"regenerating":[57,90],"or":[58],"renewing":[59],"somatic":[61],"epithelial":[62],"population":[64,218],"within":[65,195,224],"tissue.":[67],"Because":[68],"adult":[70,96,141,226],"seminal":[71,97,127,143,151,161,186,228],"vesicle":[72,152,162,187],"exhibits":[73],"ability":[75],"regenerate":[77,240],"during":[78],"androgen-replacement":[79],"after":[80],"castration,":[81],"we":[82,106,179],"hypothesized":[83],"pool":[86],"present":[93,137,223],"vesicle,":[98,144,229],"which":[99],"expresses":[100],"telomerase":[101,112,123,133,154,182],"activity.":[102],"study,":[105],"used":[107],"highly":[109],"sensitive":[110],"PCR-based":[111],"assay":[113],"[the":[114],"telomeric":[115],"repeat":[116],"amplification":[117],"protocol":[118],"(TRAP)":[119],"assay]":[120],"detect":[122],"rat":[126,142,215,227],"vesicle.":[128],"Our":[129],"results":[130,206],"show":[131],"is,":[135],"indeed,":[136],"normal":[140],"that,":[146],"presence":[149],"fluid,":[153],"cannot":[156],"be":[157],"detected.":[158],"fact,":[160],"fluid":[163],"was":[164],"found":[165,180],"factor(s)":[169],"inhibitory":[172],"TRAP":[175],"assay.":[176],"addition,":[178],"changes":[188],"age":[190],"regionally":[193],"distributed":[194],"distal,":[197],"intermediate,":[198],"proximal":[200],"segments":[201],"duct.":[204],"These":[205],"suggest":[207],"as":[209],"case":[212],"prostate,":[216],"telomerase-positive":[220],"thereby,":[231],"organ":[233],"retains":[234],"throughout":[235],"life":[236],"response":[242],"androgen":[244],"replacement":[245],"following":[246],"castration-induced":[247],"apoptotic":[248],"death.":[250]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}