{"id":"https://openalex.org/W2029315847","doi":"https://doi.org/10.2165/00002018-200932040-00007","title":"Iatrogenic Effects of COX-2 Inhibitors in the US Population","display_name":"Iatrogenic Effects of COX-2 Inhibitors in the US Population","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2029315847","doi":"https://doi.org/10.2165/00002018-200932040-00007","mag":"2029315847","pmid":"https://pubmed.ncbi.nlm.nih.gov/19388724"},"language":"en","primary_location":{"id":"doi:10.2165/00002018-200932040-00007","doi":"https://doi.org/10.2165/00002018-200932040-00007","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00002018-200932040-00007","pdf_url":null,"source":{"id":"https://openalex.org/S49488433","display_name":"Drug Safety","issn_l":"0114-5916","issn":["0114-5916","1179-1942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Safety","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052479150","display_name":"Rhema Vaithianathan","orcid":"https://orcid.org/0000-0002-8899-5254","observed_orcids":["https://orcid.org/0000-0002-8899-5254"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Rhema Vaithianathan","raw_affiliation_strings":["Department of Economics, University of Auckland, Auckland, New Zealand. r.vaithianathan@auckland.ac.nz","Department of Economics , University of Auckland , Auckland , New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Economics, University of Auckland, Auckland, New Zealand. r.vaithianathan@auckland.ac.nz","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Department of Economics , University of Auckland , Auckland , New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062201103","display_name":"Peter Hockey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter M. Hockey","raw_affiliation_strings":["Division of General Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, USA","Brigham and Women's Hospital and Harvard Medical School;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School;","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas J. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115132","display_name":"Institute for Safe Medication Practices","ror":"https://ror.org/02358mx30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Moore","raw_affiliation_strings":["Institute for Safe Medication Practices, Alexandria, Virginia, USA","Institute for Safe Medication Practices"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Safe Medication Practices, Alexandria, Virginia, USA","institution_ids":["https://openalex.org/I4210115132"]},{"raw_affiliation_string":"Institute for Safe Medication Practices","institution_ids":["https://openalex.org/I4210115132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036110536","display_name":"David Westfall Bates","orcid":"https://orcid.org/0000-0001-6268-1540","observed_orcids":["https://orcid.org/0000-0001-6268-1540","https://orcid.org/0000-0003-4850-2360","https://orcid.org/0000-0002-3105-156X","https://orcid.org/0000-0001-7438-9491","https://orcid.org/0000-0001-5440-6039"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Bates","raw_affiliation_strings":["Division of General Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, USA","Brigham and Women's Hospital and Harvard Medical School;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School;","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5052479150"],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":2.0575,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.8459878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"4","first_page":"335","last_page":"343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.9399999976158142},{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-selective-nsaids","display_name":"non-selective NSAIDs","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7139999866485596},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9200000166893005},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.984000027179718},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.9819999933242798},{"id":"https://openalex.org/keywords/disease-burden","display_name":"disease burden","score":0.7379999756813049},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7009999752044678},{"id":"https://openalex.org/keywords/medical-expenditure-panel-survey","display_name":"Medical Expenditure Panel Survey","score":0.7770000100135803},{"id":"https://openalex.org/keywords/us-population","display_name":"United States population","score":0.5540000200271606},{"id":"https://openalex.org/keywords/economic-burden","display_name":"economic burden","score":0.3880000114440918},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.421999990940094},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9809644818305969},{"id":"https://openalex.org/C2778582115","wikidata":"https://www.wikidata.org/wiki/Q411412","display_name":"Rofecoxib","level":4,"score":0.944862961769104},{"id":"https://openalex.org/C2776467144","wikidata":"https://www.wikidata.org/wiki/Q408801","display_name":"Celecoxib","level":2,"score":0.76826012134552},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.7366576194763184},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6845906972885132},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6404650211334229},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6016097664833069},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.569279134273529},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5583265423774719},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3533410429954529},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3422034978866577},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.09887748956680298},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D005102","descriptor_name":"Health Expenditures","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019538","descriptor_name":"Health Care Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2165/00002018-200932040-00007","doi":"https://doi.org/10.2165/00002018-200932040-00007","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00002018-200932040-00007","pdf_url":null,"source":{"id":"https://openalex.org/S49488433","display_name":"Drug Safety","issn_l":"0114-5916","issn":["0114-5916","1179-1942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Safety","raw_type":"journal-article"},{"id":"pmid:19388724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19388724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug safety","raw_type":"Journal Article"},{"id":"mag:2189583888","doi":null,"is_oa":false,"landing_page_url":"http://danmurphydc.com/wordpress/wp-content/uploads/articles/2010/Article_34-10_hockeyCOX.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306176","display_name":"Commonwealth Fund","ror":"https://ror.org/049kzbj92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1964032994","https://openalex.org/W1971207139","https://openalex.org/W1978939634","https://openalex.org/W1979306581","https://openalex.org/W2010860405","https://openalex.org/W2010899039","https://openalex.org/W2055028654","https://openalex.org/W2058058357","https://openalex.org/W2067621583","https://openalex.org/W2081775022","https://openalex.org/W2089597863","https://openalex.org/W2110934108","https://openalex.org/W2118219459","https://openalex.org/W2134987486","https://openalex.org/W2148359829","https://openalex.org/W2158131645","https://openalex.org/W2160976181","https://openalex.org/W2165297900","https://openalex.org/W2241048607","https://openalex.org/W2330496155"],"related_works":["https://openalex.org/W2189583888","https://openalex.org/W2097780727","https://openalex.org/W2106974656","https://openalex.org/W1995528018","https://openalex.org/W1974967703","https://openalex.org/W2079003073","https://openalex.org/W2170109137","https://openalex.org/W2022603919","https://openalex.org/W2562615747","https://openalex.org/W2047616879"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
