{"id":"https://openalex.org/W2029314510","doi":"https://doi.org/10.1139/y95-047","title":"Myocardial lipoprotein lipase activity: regulation by diabetes and fructose-induced hypertriglyceridemia","display_name":"Myocardial lipoprotein lipase activity: regulation by diabetes and fructose-induced hypertriglyceridemia","publication_year":1995,"publication_date":"1995-03-01","ids":{"openalex":"https://openalex.org/W2029314510","doi":"https://doi.org/10.1139/y95-047","mag":"2029314510","pmid":"https://pubmed.ncbi.nlm.nih.gov/7648516"},"language":"en","primary_location":{"id":"doi:10.1139/y95-047","doi":"https://doi.org/10.1139/y95-047","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y95-047","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100388544","display_name":"Limin Liu","orcid":"https://orcid.org/0000-0003-2527-7201","observed_orcids":["https://orcid.org/0000-0003-2527-7201"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Limin Liu","raw_affiliation_strings":["Medical Research Council Signal Transduction Group, Faculty of Medicine, University of Calgary, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Signal Transduction Group, Faculty of Medicine, University of Calgary, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111369897","display_name":"David L. Severson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Severson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6003,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70304606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"73","issue":"3","first_page":"369","last_page":"377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6610000133514404},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lysophosphatidylcholine","display_name":"lysophosphatidylcholine","score":0.906000018119812},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.9291002750396729},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.8544948101043701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8259444236755371},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7905086874961853},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5483142733573914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.538394033908844},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5253552794456482},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.4501285254955292},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.44665074348449707},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4444856643676758},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.42883947491645813},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.33968600630760193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3185845613479614},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2607766389846802},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2260940670967102},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17856106162071228},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.1443888247013092}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008244","descriptor_name":"Lysophosphatidylcholines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1139/y95-047","doi":"https://doi.org/10.1139/y95-047","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y95-047","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:7648516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7648516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of physiology and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065298546","https://openalex.org/W2004751707","https://openalex.org/W2058568346","https://openalex.org/W2083371341","https://openalex.org/W88536851","https://openalex.org/W2156536857","https://openalex.org/W186888532","https://openalex.org/W1993057072","https://openalex.org/W2138814207","https://openalex.org/W2344711573"],"abstract_inverted_index":{"The":[0,34,70],"decrease":[1,90],"in":[2,10,28,40,64,84,91,95,100,113,163,167,193,211,228],"myocardial":[3,114],"lipoprotein":[4],"lipase":[5],"(LPL)":[6],"activity":[7,54,94,99,116,145,166,192,214],"observed":[8],"previously":[9],"acute,":[11],"severe":[12],"models":[13],"of":[14,36,75,131,143,176,183,187,196],"insulin-deficient":[15],"diabetes":[16],"may":[17],"be":[18],"a":[19,25,76,88,140,180],"compensatory":[20],"response":[21],"to":[22,32,47,120,203],"hypertriglyceridemia":[23],"and":[24,58,60,87],"sustained":[26],"increase":[27],"fatty":[29],"acid":[30],"delivery":[31],"cardiomyocytes.":[33],"administration":[35],"fructose":[37,123],"(10%":[38],"solution":[39],"the":[41,110,147,156,160,174,184,194,209,226],"drinking":[42],"water":[43],"for":[44,223],"4":[45],"days)":[46],"rats":[48,198],"produced":[49],"hypertriglyceridemia,":[50,86,121],"but":[51,149],"heparin-releasable":[52,61,92,164,212],"LPL":[53,62,93,98,115,128,144,165,191,213,219],"from":[55,102,155],"perfused":[56,96,168],"hearts":[57,105,133,170],"total":[59],"activities":[63],"isolated":[65],"cardiomyocytes":[66,101],"were":[67],"not":[68,107,118,126,173,200,216],"reduced.":[69,108],"acute":[71],"(4":[72],"day)":[73],"induction":[74],"mild":[77],"diabetic":[78,103,169,197,229],"state":[79],"(60":[80],"mg/kg":[81],"streptozotocin)":[82],"resulted":[83],"modest":[85],"selective":[89,161],"hearts;":[97],"rat":[104,132],"was":[106,153,199,220],"Therefore,":[109],"diabetes-induced":[111],"fall":[112],"is":[117,171,215],"secondary":[119],"since":[122],"treatment":[124],"did":[125],"change":[127],"activity.":[129],"Perfusion":[130],"with":[134],"100":[135],"microM":[136],"lysophosphatidylcholine":[137],"(LPC)":[138],"released":[139],"small":[141],"amount":[142],"into":[146],"perfusate,":[148],"only":[150],"if":[151],"albumin":[152],"omitted":[154],"perfusion":[157],"solution.":[158],"Thus,":[159],"reduction":[162,210],"probably":[172],"consequence":[175],"displacement":[177],"by":[178,225],"LPC,":[179],"lipolytic":[181],"product":[182],"LPL-catalyzed":[185],"degradation":[186],"triacylglycerol-rich":[188],"lipoproteins.":[189],"Circulating":[190],"plasma":[195,205],"decreased":[201],"relative":[202],"control":[204],"enzyme":[206],"activity;":[207],"therefore,":[208],"because":[217],"circulating":[218],"less":[221],"available":[222],"uptake":[224],"endothelium":[227],"hearts.":[230]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
