{"id":"https://openalex.org/W2029309152","doi":"https://doi.org/10.1046/j.1365-2443.1996.07007.x","title":"Clamp loading, unloading and intrinsic stability of the PCNA, \u03b2 and gp45 sliding clamps of human, E. coli and T4 replicases","display_name":"Clamp loading, unloading and intrinsic stability of the PCNA, \u03b2 and gp45 sliding clamps of human, E. coli and T4 replicases","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2029309152","doi":"https://doi.org/10.1046/j.1365-2443.1996.07007.x","mag":"2029309152","pmid":"https://pubmed.ncbi.nlm.nih.gov/9078370"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2443.1996.07007.x","doi":"https://doi.org/10.1046/j.1365-2443.1996.07007.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2443.1996.07007.x","pdf_url":null,"source":{"id":"https://openalex.org/S48908450","display_name":"Genes to Cells","issn_l":"1356-9597","issn":["1356-9597","1365-2443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003107288","display_name":"Nina Y. Yao","orcid":"https://orcid.org/0000-0002-4728-6531","observed_orcids":["https://orcid.org/0000-0002-4728-6531"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210146048","display_name":"Hearst Foundations","ror":"https://ror.org/03s96de24","country_code":"US","type":"other","lineage":["https://openalex.org/I4210146048"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina Yao","raw_affiliation_strings":["Microbiology Department, Howard Hughes Medical Institute, Cornell University Medical College, New York, NY 10021, USA","Microbiology Department and Hearst Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Howard Hughes Medical Institute, Cornell University Medical College, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Microbiology Department and Hearst Research Foundation","institution_ids":["https://openalex.org/I4210146048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108692553","display_name":"Jennifer Turner","orcid":"https://orcid.org/0000-0002-2427-4546","observed_orcids":["https://orcid.org/0000-0002-2427-4546"]},"institutions":[{"id":"https://openalex.org/I4210146048","display_name":"Hearst Foundations","ror":"https://ror.org/03s96de24","country_code":"US","type":"other","lineage":["https://openalex.org/I4210146048"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Turner","raw_affiliation_strings":["Microbiology Department and Hearst Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department and Hearst Research Foundation","institution_ids":["https://openalex.org/I4210146048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026830739","display_name":"Zvi Kelman","orcid":"https://orcid.org/0000-0003-4774-3963","observed_orcids":["https://orcid.org/0000-0003-4774-3963"]},"institutions":[{"id":"https://openalex.org/I4210146048","display_name":"Hearst Foundations","ror":"https://ror.org/03s96de24","country_code":"US","type":"other","lineage":["https://openalex.org/I4210146048"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zvi Kelman","raw_affiliation_strings":["Microbiology Department and Hearst Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department and Hearst Research Foundation","institution_ids":["https://openalex.org/I4210146048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072633316","display_name":"P. Todd Stukenberg","orcid":"https://orcid.org/0000-0002-6788-2111","observed_orcids":["https://orcid.org/0000-0002-6788-2111"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Todd Stukenberg","raw_affiliation_strings":["Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Centre, 1275 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Centre, 1275 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067364412","display_name":"Frank B. Dean","orcid":"https://orcid.org/0000-0002-9416-4449","observed_orcids":["https://orcid.org/0000-0002-9416-4449"]},"institutions":[{"id":"https://openalex.org/I4210146048","display_name":"Hearst Foundations","ror":"https://ror.org/03s96de24","country_code":"US","type":"other","lineage":["https://openalex.org/I4210146048"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Dean","raw_affiliation_strings":["Microbiology Department and Hearst Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department and Hearst Research Foundation","institution_ids":["https://openalex.org/I4210146048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059390481","display_name":"David Shechter","orcid":"https://orcid.org/0000-0001-9388-6004","observed_orcids":["https://orcid.org/0000-0001-9388-6004"]},"institutions":[{"id":"https://openalex.org/I4210146048","display_name":"Hearst Foundations","ror":"https://ror.org/03s96de24","country_code":"US","type":"other","lineage":["https://openalex.org/I4210146048"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Shechter","raw_affiliation_strings":["Microbiology Department and Hearst Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department and Hearst Research Foundation","institution_ids":["https://openalex.org/I4210146048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031987061","display_name":"Zhen\u2010Qiang Pan","orcid":"https://orcid.org/0000-0001-9504-8768","observed_orcids":["https://orcid.org/0000-0001-9504-8768"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen\u2010Qiang Pan","raw_affiliation_strings":["Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Centre, 1275 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Centre, 1275 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114011472","display_name":"Jerard Hurwitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerard Hurwitz","raw_affiliation_strings":["Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Centre, 1275 York Avenue, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Centre, 1275 York Avenue, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051770888","display_name":"Mike E. O\u2019Donnell","orcid":"https://orcid.org/0000-0001-9002-4214","observed_orcids":["https://orcid.org/0000-0001-9002-4214","https://orcid.org/0000-0002-8928-8068"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike O'Donnell","raw_affiliation_strings":["Howard Hughes Medical Institute, Cornell University Medical College, 1300 York Avenue, New York, HY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Cornell University Medical College, 1300 York Avenue, New York, HY 10021, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":4.0422,"has_fulltext":false,"cited_by_count":214,"citation_normalized_percentile":{"value":0.94984351,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"101","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sliding-clamp","display_name":"sliding clamp","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.8840000033378601},{"id":"https://openalex.org/keywords/beta-sliding-clamp","display_name":"beta sliding clamp","score":0.7450000047683716},{"id":"https://openalex.org/keywords/clamp-loader","display_name":"clamp loader","score":0.7409999966621399},{"id":"https://openalex.org/keywords/dna-polymerase","display_name":"DNA polymerase","score":0.5130000114440918},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.652999997138977},{"id":"https://openalex.org/keywords/bacteriophage-t4","display_name":"bacteriophage T4","score":0.9449999928474426},{"id":"https://openalex.org/keywords/oligomeric-state","display_name":"oligomeric state","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C131140672","wikidata":"https://www.wikidata.org/wiki/Q2031164","display_name":"Processivity","level":4,"score":0.9345578551292419},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.8783701062202454},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.7488300800323486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6710001826286316},{"id":"https://openalex.org/C76535049","wikidata":"https://www.wikidata.org/wiki/Q3487941","display_name":"DNA polymerase delta","level":5,"score":0.6283325552940369},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.5975711941719055},{"id":"https://openalex.org/C2776161997","wikidata":"https://www.wikidata.org/wiki/Q846600","display_name":"Clamp","level":3,"score":0.5603564977645874},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.548757791519165},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5272965431213379},{"id":"https://openalex.org/C17133392","wikidata":"https://www.wikidata.org/wiki/Q5158263","display_name":"Concatemer","level":4,"score":0.5164608955383301},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5163403749465942},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4997837543487549},{"id":"https://openalex.org/C188036394","wikidata":"https://www.wikidata.org/wiki/Q14902224","display_name":"Replication factor C","level":5,"score":0.4897589683532715},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.4795365333557129},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4279506504535675},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38940006494522095},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.3115231990814209},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2989586591720581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15916430950164795},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.10553678870201111},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.09237802028656006},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.08223259449005127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07423833012580872},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C84111939","wikidata":"https://www.wikidata.org/wiki/Q5125465","display_name":"Clamping","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017122","descriptor_name":"Bacteriophage T4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2443.1996.07007.x","doi":"https://doi.org/10.1046/j.1365-2443.1996.07007.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2443.1996.07007.x","pdf_url":null,"source":{"id":"https://openalex.org/S48908450","display_name":"Genes to Cells","issn_l":"1356-9597","issn":["1356-9597","1365-2443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to Cells","raw_type":"journal-article"},{"id":"pmid:9078370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9078370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to cells : devoted to molecular & cellular mechanisms","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1443451985","display_name":null,"funder_award_id":"GM 38839","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1507551858","https://openalex.org/W1515794053","https://openalex.org/W1517952165","https://openalex.org/W1535209874","https://openalex.org/W1539813750","https://openalex.org/W1540214411","https://openalex.org/W1551254087","https://openalex.org/W1560122944","https://openalex.org/W1563822695","https://openalex.org/W1574197136","https://openalex.org/W1575153043","https://openalex.org/W1579564253","https://openalex.org/W1580231709","https://openalex.org/W1605120960","https://openalex.org/W1605482400","https://openalex.org/W1641219603","https://openalex.org/W1687302736","https://openalex.org/W1957748504","https://openalex.org/W1965743560","https://openalex.org/W1988018492","https://openalex.org/W1990822018","https://openalex.org/W1994245744","https://openalex.org/W1995246974","https://openalex.org/W2003282728","https://openalex.org/W2009412786","https://openalex.org/W2009509451","https://openalex.org/W2012863320","https://openalex.org/W2026307236","https://openalex.org/W2029775771","https://openalex.org/W2033224916","https://openalex.org/W2041249795","https://openalex.org/W2047577950","https://openalex.org/W2062424882","https://openalex.org/W2065014822","https://openalex.org/W2067045625","https://openalex.org/W2072962498","https://openalex.org/W2079718256","https://openalex.org/W2122748184","https://openalex.org/W2144634347","https://openalex.org/W2149707384","https://openalex.org/W2171367003"],"related_works":["https://openalex.org/W1997721375","https://openalex.org/W2008097245","https://openalex.org/W1993651081","https://openalex.org/W2043542498","https://openalex.org/W4230602081","https://openalex.org/W3176654297","https://openalex.org/W2093713323","https://openalex.org/W1557374814","https://openalex.org/W1972794006","https://openalex.org/W2056520996"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,55,82,126,188,218,268,291,321,345],"high":[2],"speed":[3],"and":[4,30,42,70,75,122,151,170,204,225,233,256,272,326,340,350],"processivity":[5,13,46],"of":[6,112,119,220,235,253,278,288,293,309,323,348,360],"replicative":[7],"DNA":[8,29,154,172,214,246,260,284,342],"polymerases":[9],"reside":[10],"in":[11,39,164,285,297],"a":[12,21,65,91,96,130,135,193,231],"factor":[14,335],"which":[15,179],"has":[16],"been":[17],"shown":[18],"to":[19,35,101,134,210,316,336],"be":[20,181],"ring-shaped":[22],"protein.":[23],"This":[24,108],"protein":[25,92],"(\"sliding":[26],"clamp')":[27],"encircles":[28],"tethers":[31],"the":[32,36,45,68,103,106,113,146,208,236,240,250,254,286,294,306,310,314,324,358],"catalytic":[33],"unit":[34],"template.":[37],"Although":[38],"eukaryotic,":[40],"prokaryotic":[41],"bacteriophage-T4":[43],"systems,":[44],"factors":[47],"are":[48,78],"ring-shaped,":[49],"they":[50,330],"assume":[51],"different":[52,295],"oligomeric":[53,186],"states.":[54],"Escherichia":[56],"coli":[57,121],"clamp":[58,83,97,116,148,191,224,242,269,312,346,354,361],"(the":[59],"beta":[60,160,257,327,351],"subunit)":[61],"is":[62,129,161,192,227],"active":[63,79,263],"as":[64,80,95,215,353],"dimer":[66],"while":[67],"eukaryotic":[69],"T4":[71,123,189,311],"phage":[72],"clamps":[73,258,282,296,328],"(PCNA":[74],"gp45,":[76],"respectively)":[77],"trimers.":[81],"can":[84],"not":[85],"assemble":[86,102],"itself":[87],"on":[88,171,213,259,303,319,339],"DNA.":[89,304,320],"Instead,":[90],"complex":[93],"known":[94],"loader":[98],"utilizes":[99],"ATP":[100],"ring":[104,128],"around":[105],"primer-template.":[107],"study":[109],"compares":[110],"properties":[111],"human":[114],"PCNA":[115,127,147,178,199,255,325,349],"with":[117,207,300],"those":[118],"E.":[120],"phage.":[124],"RESULTS:":[125],"stable":[131,163,196],"trimer":[132,197],"down":[133],"concentration":[136],"below":[137],"100":[138],"nM":[139],"(Kd":[140,166,200],"approximately":[141,157,174,201],"21":[142],"nM).":[143],"On":[144],"DNA,":[145,239],"slides":[149],"freely":[150],"dissociates":[152,244],"from":[153,238,245,283],"slowly":[155],"(t1/2":[156,173],"24":[158],"min).":[159],"more":[162],"solution":[165,298],"<":[167],"60":[168],"PM)":[169],"1":[175],"h)":[176],"than":[177,198],"may":[180],"explained":[182],"by":[183],"its":[184],"simpler":[185],"state.":[187],"gp45":[190,241,318],"much":[194],"less":[195],"250":[202],"nM)":[203],"requires":[205],"association":[206],"polymerase":[209,226,237],"stabilize":[211],"it":[212],"observed":[216],"previously.":[217],"consequence":[219],"this":[221],"cooperation":[222],"between":[223],"that":[228],"upon":[229],"finishing":[230],"template":[232],"dissociation":[234],"spontaneously":[243],"without":[247],"assistance.":[248],"However,":[249],"greater":[251],"stability":[252,292,302,308,322],"necessitates":[261],"an":[262,333],"process":[264],"for":[265,357],"their":[266,280,301],"removal.":[267],"loaders":[270,347],"(RFC":[271],"gamma":[273],"complex)":[274],"were":[275],"also":[276],"capable":[277],"unloading":[279,334],"respective":[281],"presence":[287],"ATP.":[289],"CONCLUSIONS:":[290],"correlates":[299],"Thus,":[305],"low":[307],"explains":[313],"inability":[315],"isolate":[317],"predicts":[329],"will":[331],"require":[332],"recycle":[337],"them":[338],"off":[341],"during":[343],"replication.":[344],"double":[352],"unloaders":[355],"presumably":[356],"purpose":[359],"recycling.":[362]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}