{"id":"https://openalex.org/W2029304579","doi":"https://doi.org/10.4161/cc.9.18.12993","title":"apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53","display_name":"apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53","publication_year":2010,"publication_date":"2010-09-15","ids":{"openalex":"https://openalex.org/W2029304579","doi":"https://doi.org/10.4161/cc.9.18.12993","mag":"2029304579","pmid":"https://pubmed.ncbi.nlm.nih.gov/20890106"},"language":"en","primary_location":{"id":"doi:10.4161/cc.9.18.12993","doi":"https://doi.org/10.4161/cc.9.18.12993","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.18.12993","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.18.12993?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.18.12993?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057180441","display_name":"Osnat Ashur\u2010Fabian","orcid":"https://orcid.org/0000-0001-8624-3182","observed_orcids":["https://orcid.org/0000-0001-8624-3182"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Osnat Ashur-Fabian","raw_affiliation_strings":["Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","Sheba Medical Center at Tel Hashomer","Tel-Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083143249","display_name":"Adi Har\u2010Zahav","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Adi Har-Zahav","raw_affiliation_strings":["Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","Sheba Medical Center at Tel Hashomer","Tel-Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070045481","display_name":"Aviv Shaish","orcid":"https://orcid.org/0000-0003-0203-9569","observed_orcids":["https://orcid.org/0000-0003-0203-9569"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aviv Shaish","raw_affiliation_strings":["Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","the Bert W. Strassburger Lipid Center ; Sheba Medical Center ; tel-Hashomer , Israel;","Sheba Medical Center at Tel Hashomer","Tel Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"the Bert W. Strassburger Lipid Center ; Sheba Medical Center ; tel-Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017612439","display_name":"Hila Wiener Amram","orcid":"https://orcid.org/0000-0002-3315-2030","observed_orcids":["https://orcid.org/0000-0002-3315-2030"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hila Wiener Amram","raw_affiliation_strings":["Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","Sheba Medical Center at Tel Hashomer","Tel-Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010952997","display_name":"Ofer Margalit","orcid":"https://orcid.org/0000-0003-0319-9038","observed_orcids":["https://orcid.org/0000-0003-0319-9038"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ofer Margalit","raw_affiliation_strings":["Sackler Faculty of Medicine , Tel Aviv University , Israel","Sheba Medical Center at Tel Hashomer","Tel-Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Faculty of Medicine , Tel Aviv University , Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111858484","display_name":"Orly Weizer\u2010Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Orly Weizer-Stern","raw_affiliation_strings":["Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","Sheba Medical Center at Tel Hashomer","Tel-Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076668330","display_name":"Dan Dominissini","orcid":"https://orcid.org/0000-0003-1121-5130","observed_orcids":["https://orcid.org/0000-0003-1121-5130"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dan Dominissini","raw_affiliation_strings":["Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","Sheba Medical Center at Tel Hashomer","Tel-Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075176331","display_name":"Dror Harats","orcid":"https://orcid.org/0009-0009-6456-6752","observed_orcids":["https://orcid.org/0009-0009-6456-6752"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dror Harats","raw_affiliation_strings":["Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","the Bert W. Strassburger Lipid Center ; Sheba Medical Center ; tel-Hashomer , Israel;","Sheba Medical Center at Tel Hashomer","Tel Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"the Bert W. Strassburger Lipid Center ; Sheba Medical Center ; tel-Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082558562","display_name":"Ninette Amariglio","orcid":"https://orcid.org/0000-0002-2079-6718","observed_orcids":["https://orcid.org/0000-0002-2079-6718"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ninette Amariglio","raw_affiliation_strings":["Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","Sheba Medical Center at Tel Hashomer","Tel-Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sheba Medical Center at Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071994598","display_name":"Gideon Rechavi","orcid":"https://orcid.org/0000-0002-4594-1811","observed_orcids":["https://orcid.org/0000-0002-4594-1811"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gideon Rechavi","raw_affiliation_strings":["Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","Cancer Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center ; Sheba Medical Center ; tel Hashomer , Israel;","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler School of Medicine ; tel Aviv University ; tel Aviv , Israel;","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Cancer Research Center","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057180441"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"],"apc_list":null,"apc_paid":null,"fwci":3.2476,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.92374771,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"18","first_page":"3785","last_page":"3794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.996999979019165},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9829999804496765},{"id":"https://openalex.org/keywords/apobec1","display_name":"APOBEC1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rna-editing","display_name":"RNA editing","score":0.6639999747276306},{"id":"https://openalex.org/keywords/p53-response-element","display_name":"p53 response elements","score":0.9110000133514404},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9900000095367432},{"id":"https://openalex.org/keywords/atherogenic-lipoproteins","display_name":"atherogenic lipoproteins","score":0.9279999732971191},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/intestinal-gene-expression","display_name":"intestinal gene expression","score":0.5509999990463257},{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8339084386825562},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.7867273092269897},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6369507312774658},{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.5937574505805969},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5594783425331116},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49214547872543335},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.4902975857257843},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.47726911306381226},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4699839651584625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3280455470085144},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3004879355430603},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.27326273918151855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1882058084011078},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.1122814416885376},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071479","descriptor_name":"APOBEC-1 Deaminase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/cc.9.18.12993","doi":"https://doi.org/10.4161/cc.9.18.12993","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.18.12993","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.18.12993?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:20890106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20890106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cc.9.18.12993","doi":"https://doi.org/10.4161/cc.9.18.12993","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.18.12993","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.18.12993?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308625","display_name":"Flight Attendant Medical Research Institute","ror":"https://ror.org/00ybhm522"},{"id":"https://openalex.org/F4320322250","display_name":"Israel Cancer Association","ror":"https://ror.org/03yxd7304"},{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"},{"id":"https://openalex.org/F4320325464","display_name":"Wolfson Family Charitable Trust","ror":"https://ror.org/03h1she57"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2029304579.pdf","grobid_xml":"https://content.openalex.org/works/W2029304579.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W114697155","https://openalex.org/W1596495551","https://openalex.org/W1606722513","https://openalex.org/W1639110856","https://openalex.org/W1844787848","https://openalex.org/W1964719993","https://openalex.org/W1964852585","https://openalex.org/W1979262539","https://openalex.org/W1979319210","https://openalex.org/W1980262173","https://openalex.org/W1986245375","https://openalex.org/W1987378840","https://openalex.org/W1991421363","https://openalex.org/W1993238204","https://openalex.org/W2002971066","https://openalex.org/W2009845042","https://openalex.org/W2011912935","https://openalex.org/W2017488005","https://openalex.org/W2021517975","https://openalex.org/W2042075518","https://openalex.org/W2046288058","https://openalex.org/W2048797704","https://openalex.org/W2059021008","https://openalex.org/W2060275129","https://openalex.org/W2063669247","https://openalex.org/W2063919394","https://openalex.org/W2074222004","https://openalex.org/W2082374255","https://openalex.org/W2088905535","https://openalex.org/W2089714862","https://openalex.org/W2094957670","https://openalex.org/W2095771807","https://openalex.org/W2104585933","https://openalex.org/W2116009473","https://openalex.org/W2120203140","https://openalex.org/W2122574397","https://openalex.org/W2123747922","https://openalex.org/W2145946420","https://openalex.org/W2167830683","https://openalex.org/W2319146208","https://openalex.org/W2328936309"],"related_works":["https://openalex.org/W2127953736","https://openalex.org/W2063919394","https://openalex.org/W2142252299","https://openalex.org/W2065417886","https://openalex.org/W2101037254","https://openalex.org/W1987378840","https://openalex.org/W2337901591","https://openalex.org/W2129988804","https://openalex.org/W2014680643","https://openalex.org/W1986265010"],"abstract_inverted_index":{"p53":[0,45,92,116,137,157,177,194],"is":[1],"an":[2,154],"established":[3],"tumor":[4],"suppressor":[5],"gene":[6],"activating":[7],"the":[8,50,139,151,159,164,179],"transcription":[9,140,165],"of":[10,97,141,156,166,182],"multiple":[11],"target":[12],"genes.":[13],"Apolipoprotein":[14],"B":[15,36],"(apo":[16],"B),":[17],"a":[18,30,90,172,186],"dietary":[19],"lipid":[20,144],"transporter,":[21],"occurs":[22],"as":[23],"apo":[24,35],"B-100":[25],"and":[26,55,61,68,99,101,120,185],"apoB-48,":[27],"created":[28],"by":[29,34,62,82],"premature":[31],"stop":[32],"codon":[33],"mRNA-editing":[37],"enzyme":[38],"complex":[39],"1":[40],"(apobec1).":[41],"We":[42,147],"have":[43,134],"identified":[44,135],"response":[46],"elements":[47],"(p53RE)":[48],"in":[49,71,158,178,192],"genes":[51,78,191],"encoding":[52],"for":[53,150,176,189],"apoB":[54,98,103,122],"apobec1,":[56],"cloned":[57],"these":[58,77,190],"novel":[59],"p53RE":[60],"performing":[63],"functionality,":[64],"chromatin":[65],"immunoprecipitation":[66],"(ChIP)":[67],"expression":[69,96,127],"assays":[70],"cancer":[72],"cell":[73],"lines,":[74],"confirmed":[75],"that":[76,136],"are":[79],"transcriptionally":[80],"regulated":[81],"p53.":[83],"In":[84,108,130],"C57bl/6":[85],"mice":[86,113],"treated":[87],"with":[88],"adriamycin,":[89],"potent":[91],"inducer,":[93],"intestinal/liver":[94],"mRNA":[95,126],"apobec1":[100,125],"liver":[102,119],"editing":[104,161],"levels":[105],"were":[106],"elevated.":[107,129],"irradiated":[109],"wild":[110],"type":[111],"C57bl6":[112],"but":[114,123],"not":[115,124],"knockout":[117],"mice,":[118],"intestine":[121],"was":[128],"this":[131],"work,":[132],"we":[133],"regulates":[138],"two":[142],"central":[143],"metabolism":[145],"players.":[146],"further":[148],"show,":[149],"first":[152],"time,":[153],"involvement":[155],"RNA":[160],"process,":[162],"through":[163],"apobec1.":[167],"Our":[168],"findings":[169],"may":[170],"reveal":[171],"previously":[173],"unknown":[174],"role":[175,188],"direct":[180],"regulation":[181],"atherogenic":[183],"lipoproteins":[184],"possible":[187],"classical":[193],"activities.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}