{"id":"https://openalex.org/W2029282156","doi":"https://doi.org/10.1016/s0168-8278(09)60209-9","title":"207 SAFETY OF RIFAXIMIN IN PATIENTS WITH HEPATIC ENCEPHALOPATHY: RESULTS OF A RANDOMIZED, PHASE 3, PLACEBO-CONTROLLED CLINICAL TRIAL","display_name":"207 SAFETY OF RIFAXIMIN IN PATIENTS WITH HEPATIC ENCEPHALOPATHY: RESULTS OF A RANDOMIZED, PHASE 3, PLACEBO-CONTROLLED CLINICAL TRIAL","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2029282156","doi":"https://doi.org/10.1016/s0168-8278(09)60209-9","mag":"2029282156"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8278(09)60209-9","doi":"https://doi.org/10.1016/s0168-8278(09)60209-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0168-8278(09)60209-9","pdf_url":"https://doi.org/10.1016/s0168-8278(09)60209-9","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/s0168-8278(09)60209-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111604419","display_name":"Kathleen A. Mullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["DK","GB","US"],"is_corresponding":false,"raw_author_name":"K. Mullen","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH,","Centre for Hepatology, Royal Free Campus, University College London","Department of Clinical Physiology 239, Hvidovre Hospital, University of Copenhagen, Hvidovre,","Medical School, University College London, London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH,","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Centre for Hepatology, Royal Free Campus, University College London","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Clinical Physiology 239, Hvidovre Hospital, University of Copenhagen, Hvidovre,","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801942218"]},{"raw_affiliation_string":"Medical School, University College London, London,","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051869692","display_name":"Samuel Harold Sigal","orcid":"https://orcid.org/0000-0003-1092-8083","observed_orcids":["https://orcid.org/0000-0003-1092-8083"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["DK","GB","US"],"is_corresponding":false,"raw_author_name":"S. Sigal","raw_affiliation_strings":["Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK","Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen,","Weill Medical College of Cornell University, New York, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK","institution_ids":["https://openalex.org/I28290843"]},{"raw_affiliation_string":"Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen,","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Weill Medical College of Cornell University, New York, New York,","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Sheikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"M. Sheikh","raw_affiliation_strings":["Department of Medical Gastroenterology 439, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark","University of California San Francisco, Fresno, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Gastroenterology 439, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801942218"]},{"raw_affiliation_string":"University of California San Francisco, Fresno, CA,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113608207","display_name":"Nathan M. Bass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Bass","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042613443","display_name":"Fred F Poordad","orcid":"https://orcid.org/0000-0002-1503-1569","observed_orcids":["https://orcid.org/0000-0002-1503-1569"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Poordad","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA,","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109960584","display_name":"Kunal Merchant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270783","display_name":"Salix Pharmaceuticals (United States)","ror":"https://ror.org/01akhf054","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Merchant","raw_affiliation_strings":["Salix Pharmaceuticals, Inc, Morrisville, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salix Pharmaceuticals, Inc, Morrisville, NC, USA","institution_ids":["https://openalex.org/I4405270783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076116251","display_name":"Shirley Chien-Chieh Huang","orcid":"https://orcid.org/0000-0001-8196-911X","observed_orcids":["https://orcid.org/0000-0001-8196-911X"]},"institutions":[{"id":"https://openalex.org/I4405270783","display_name":"Salix Pharmaceuticals (United States)","ror":"https://ror.org/01akhf054","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Huang","raw_affiliation_strings":["Salix Pharmaceuticals, Inc, Morrisville, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salix Pharmaceuticals, Inc, Morrisville, NC, USA","institution_ids":["https://openalex.org/I4405270783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035839631","display_name":"Anita Shaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270783","display_name":"Salix Pharmaceuticals (United States)","ror":"https://ror.org/01akhf054","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Shaw","raw_affiliation_strings":["Salix Pharmaceuticals, Inc, Morrisville, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salix Pharmaceuticals, Inc, Morrisville, NC, USA","institution_ids":["https://openalex.org/I4405270783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027756028","display_name":"Enoch B. Bortey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270783","display_name":"Salix Pharmaceuticals (United States)","ror":"https://ror.org/01akhf054","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Bortey","raw_affiliation_strings":["Salix Pharmaceuticals, Inc, Morrisville, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salix Pharmaceuticals, Inc, Morrisville, NC, USA","institution_ids":["https://openalex.org/I4405270783"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110094633","display_name":"William P. Forbes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270783","display_name":"Salix Pharmaceuticals (United States)","ror":"https://ror.org/01akhf054","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Forbes","raw_affiliation_strings":["Salix Pharmaceuticals, Inc, Morrisville, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salix Pharmaceuticals, Inc, Morrisville, NC, USA","institution_ids":["https://openalex.org/I4405270783"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.6108,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73621669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"50","issue":null,"first_page":"S84","last_page":"S85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifaximin","display_name":"rifaximin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9750000238418579},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.8669999837875366},{"id":"https://openalex.org/keywords/liver-stiffness","display_name":"liver stiffness","score":0.8109999895095825},{"id":"https://openalex.org/keywords/transient-elastography","display_name":"transient elastography","score":0.8790000081062317},{"id":"https://openalex.org/keywords/valsalva-maneuver","display_name":"Valsalva maneuver","score":0.859000027179718},{"id":"https://openalex.org/keywords/venous-pressure","display_name":"venous pressure","score":0.7910000085830688},{"id":"https://openalex.org/keywords/diuretic-therapy","display_name":"diuretic therapy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/esophageal-varices","display_name":"esophageal varices","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2778889925","wikidata":"https://www.wikidata.org/wiki/Q416073","display_name":"Rifaximin","level":3,"score":0.9779121279716492},{"id":"https://openalex.org/C2780325230","wikidata":"https://www.wikidata.org/wiki/Q642548","display_name":"Hepatic encephalopathy","level":3,"score":0.8339124917984009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7124418020248413},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7028167843818665},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5663052797317505},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5045732259750366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4813274145126343},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40311405062675476},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.12339633703231812},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08739307522773743},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.05057680606842041},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.04679471254348755},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.032278597354888916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0168-8278(09)60209-9","doi":"https://doi.org/10.1016/s0168-8278(09)60209-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0168-8278(09)60209-9","pdf_url":"https://doi.org/10.1016/s0168-8278(09)60209-9","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0168-8278(09)60209-9","doi":"https://doi.org/10.1016/s0168-8278(09)60209-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0168-8278(09)60209-9","pdf_url":"https://doi.org/10.1016/s0168-8278(09)60209-9","source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2029282156.pdf","grobid_xml":"https://content.openalex.org/works/W2029282156.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075439560","https://openalex.org/W2010421601","https://openalex.org/W2332442467","https://openalex.org/W2081814295","https://openalex.org/W2913298133","https://openalex.org/W2026086106","https://openalex.org/W2788836091","https://openalex.org/W2065185265","https://openalex.org/W2171209257","https://openalex.org/W3033703140"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}