{"id":"https://openalex.org/W2029177281","doi":"https://doi.org/10.1002/glia.20365","title":"Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: Heterogeneity of the quiescent phenotype","display_name":"Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: Heterogeneity of the quiescent phenotype","publication_year":2006,"publication_date":"2006-07-03","ids":{"openalex":"https://openalex.org/W2029177281","doi":"https://doi.org/10.1002/glia.20365","mag":"2029177281","pmid":"https://pubmed.ncbi.nlm.nih.gov/16819765"},"language":"en","primary_location":{"id":"doi:10.1002/glia.20365","doi":"https://doi.org/10.1002/glia.20365","is_oa":true,"landing_page_url":"https://doi.org/10.1002/glia.20365","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/glia.20365","source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/glia.20365","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087001955","display_name":"Vivianne L. Tawfik","orcid":"https://orcid.org/0000-0002-4422-2014","observed_orcids":["https://orcid.org/0000-0002-4422-2014"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivianne L. Tawfik","raw_affiliation_strings":["Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03756, USA","Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire","Neuroscience Center at Dartmouth, Lebanon, New Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03756, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Neuroscience Center at Dartmouth, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018040308","display_name":"Michael L. LaCroix\u2010Fralish","orcid":"https://orcid.org/0000-0002-8850-5972","observed_orcids":["https://orcid.org/0000-0002-8850-5972"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Lacroix\u2010Fralish","raw_affiliation_strings":["Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire","Neuroscience Center at Dartmouth, Lebanon, New Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Neuroscience Center at Dartmouth, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077098416","display_name":"Kathryn K. Bercury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn K. Bercury","raw_affiliation_strings":["Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire","Neuroscience Center at Dartmouth, Lebanon, New Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I1289422878"]},{"raw_affiliation_string":"Neuroscience Center at Dartmouth, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030970056","display_name":"Nancy Nutile\u2010McMenemy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Nutile\u2010Mcmenemy","raw_affiliation_strings":["Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire","Neuroscience Center at Dartmouth, Lebanon, New Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I1289422878"]},{"raw_affiliation_string":"Neuroscience Center at Dartmouth, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023448259","display_name":"Brent T. Harris","orcid":"https://orcid.org/0000-0002-9746-4906","observed_orcids":["https://orcid.org/0000-0002-9746-4906"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brent T. Harris","raw_affiliation_strings":["Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire","Neuroscience Center at Dartmouth, Lebanon, New Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I1289422878"]},{"raw_affiliation_string":"Neuroscience Center at Dartmouth, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033359819","display_name":"Joyce A. DeLeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joyce A. Deleo","raw_affiliation_strings":["Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire","Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire","Neuroscience Center at Dartmouth, Lebanon, New Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I1289422878"]},{"raw_affiliation_string":"Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Neuroscience Center at Dartmouth, Lebanon, New Hampshire","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033359819"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":2.2105,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.86776808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"54","issue":"3","first_page":"193","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propentofylline","display_name":"propentofylline","score":0.9980000257492065},{"id":"https://openalex.org/keywords/astrocyte-differentiation","display_name":"astrocyte differentiation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.6320000290870667},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.9300000071525574},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.7509999871253967},{"id":"https://openalex.org/keywords/reactive-astrocytes","display_name":"reactive astrocytes","score":0.871999979019165},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chemokine-secretion","display_name":"chemokine secretion","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8960000276565552},{"id":"https://openalex.org/keywords/astrocyte-phenotype","display_name":"astrocyte phenotype","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.8619288802146912},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7597111463546753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.608389139175415},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.5867629051208496},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4844250977039337},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4839823246002197},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4678877890110016},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46292659640312195},{"id":"https://openalex.org/C2779319286","wikidata":"https://www.wikidata.org/wiki/Q415744","display_name":"Riluzole","level":4,"score":0.41436532139778137},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29626160860061646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20899206399917603},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19309523701667786},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14178219437599182},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.13263431191444397},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08392283320426941},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.074439138174057}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/glia.20365","doi":"https://doi.org/10.1002/glia.20365","is_oa":true,"landing_page_url":"https://doi.org/10.1002/glia.20365","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/glia.20365","source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmid:16819765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16819765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/glia.20365","doi":"https://doi.org/10.1002/glia.20365","is_oa":true,"landing_page_url":"https://doi.org/10.1002/glia.20365","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/glia.20365","source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5793309572","display_name":"Alternatives to Opioids for Chronic Pain: Part IV","funder_award_id":"R01DA011276","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2029177281.pdf","grobid_xml":"https://content.openalex.org/works/W2029177281.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W62247276","https://openalex.org/W1588361932","https://openalex.org/W1964119066","https://openalex.org/W1964953009","https://openalex.org/W1965933264","https://openalex.org/W1966936071","https://openalex.org/W1969400861","https://openalex.org/W1970900916","https://openalex.org/W1976219259","https://openalex.org/W1981014302","https://openalex.org/W1983197885","https://openalex.org/W1983845775","https://openalex.org/W1991701465","https://openalex.org/W1992206444","https://openalex.org/W2006050476","https://openalex.org/W2007872436","https://openalex.org/W2010067410","https://openalex.org/W2015356286","https://openalex.org/W2022671065","https://openalex.org/W2036020592","https://openalex.org/W2037253766","https://openalex.org/W2043974564","https://openalex.org/W2046770212","https://openalex.org/W2055197670","https://openalex.org/W2067358754","https://openalex.org/W2068675229","https://openalex.org/W2092088681","https://openalex.org/W2092358916","https://openalex.org/W2094673798","https://openalex.org/W2094920761","https://openalex.org/W2095267065","https://openalex.org/W2107277218","https://openalex.org/W2116903459","https://openalex.org/W2126112217","https://openalex.org/W2128744963","https://openalex.org/W2158453961","https://openalex.org/W2160316566","https://openalex.org/W2160644313","https://openalex.org/W2162026041","https://openalex.org/W2170019750","https://openalex.org/W2170604570","https://openalex.org/W2403978899","https://openalex.org/W2429572096","https://openalex.org/W4210979710"],"related_works":["https://openalex.org/W2094902133","https://openalex.org/W2130302629","https://openalex.org/W2429572096","https://openalex.org/W1821568019","https://openalex.org/W2049221366","https://openalex.org/W3031625765","https://openalex.org/W1506745232","https://openalex.org/W2389299115","https://openalex.org/W2116053253","https://openalex.org/W2074462624"],"abstract_inverted_index":{"Reactive":[0],"astrocytes":[1,22,100,173,217,234],"display":[2,102],"decreased":[3],"glutamate":[4,14,53,158,170,242],"transporters,":[5],"such":[6],"as":[7,10,113,115],"GLT-1,":[8],"and":[9,25,52,70,109,118,130,145,148,212,244],"a":[11,67,91,103,110,139,164,236],"result":[12],"synaptic":[13],"clearance":[15,243],"is":[16,189,230],"impaired.":[17],"In":[18],"addition,":[19],"these":[20,151],"activated":[21,64],"are":[23],"immunocompetent":[24],"release":[26,200,215],"algesic":[27],"mediators":[28],"that":[29,123,136,181,228,247],"can":[30],"sensitize":[31],"neurons":[32],"in":[33,150,157,172],"the":[34,40,50,154,193],"spinal":[35],"cord.":[36],"Currently,":[37],"we":[38],"evaluated":[39],"effect":[41,194],"of":[42,56,94,143,195,232],"propentofylline":[43],"(PPF),":[44],"an":[45,63],"experimental":[46],"antiallodynic":[47],"agent,":[48],"on":[49,197],"phenotype":[51,65],"transporter":[54],"expression":[55],"astrocytes.":[57,152],"Primary":[58],"astrocyte":[59],"cultures,":[60],"which":[61],"represent":[62],"with":[66,81,106,125,167,175],"polygonal":[68],"morphology":[69],"low":[71],"GLT-1":[72,95,117,144,190],"expression,":[73],"were":[74],"treated":[75,174],"for":[76,241],"3":[77],"or":[78,84,88,177],"7":[79],"days":[80],"10,":[82],"100,":[83],"1,000":[85,178],"microM":[86,179],"PPF":[87,97,137,180,196,204,229],"dibutyryl-cAMP":[89],"(db-cAMP),":[90],"known":[92],"inducer":[93],"expression.":[96,224],"dose-dependently":[98],"induced":[99,248],"to":[101,122,162,184,207,235],"mature":[104,238],"phenotype,":[105,239],"elongated":[107],"processes":[108],"stellate":[111],"shape,":[112],"well":[114],"increased":[116],"GLAST":[119,146],"immunoreactivity,":[120],"similar":[121],"seen":[124],"db-cAMP.":[126,250],"Real":[127],"time":[128],"RT-PCR":[129],"Western":[131],"blot":[132],"analysis":[133],"clearly":[134],"demonstrated":[135],"caused":[138],"potent":[140],"dose-dependent":[141],"induction":[142],"mRNA":[147],"protein":[149],"Importantly,":[153],"observed":[155],"increase":[156],"transporters":[159],"was":[160,182,201,205],"found":[161],"have":[163],"functional":[165],"effect,":[166],"significantly":[168,220],"enhanced":[169,221],"uptake":[171],"100":[176],"sensitive":[183],"dihydrokainate":[185],"inhibition,":[186],"suggesting":[187],"it":[188],"mediated.":[191],"Finally,":[192],"lipopolysaccharide-induced":[198],"chemokine":[199,223],"investigated.":[202],"Interestingly,":[203],"able":[206],"dampen":[208],"both":[209],"MCP-1":[210],"(CCL2)":[211],"MIP-2":[213],"(CXCL2)":[214],"from":[216,246],"while":[218],"db-cAMP":[219],"this":[222],"These":[225],"findings":[226],"suggest":[227],"capable":[231],"differentiating":[233],"homeostatic,":[237],"competent":[240],"distinct":[245],"by":[249]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
