{"id":"https://openalex.org/W2029106536","doi":"https://doi.org/10.1016/0002-9378(89)90540-1","title":"Immunoregulatory activity in supernatants from cultures of normal human trophoblast cells of the first trimester","display_name":"Immunoregulatory activity in supernatants from cultures of normal human trophoblast cells of the first trimester","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W2029106536","doi":"https://doi.org/10.1016/0002-9378(89)90540-1","mag":"2029106536","pmid":"https://pubmed.ncbi.nlm.nih.gov/2475020"},"language":"en","primary_location":{"id":"doi:10.1016/0002-9378(89)90540-1","doi":"https://doi.org/10.1016/0002-9378(89)90540-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0002-9378(89)90540-1","pdf_url":"https://doi.org/10.1016/0002-9378(89)90540-1","source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/0002-9378(89)90540-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109320361","display_name":"Mrinal K. Sanyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mrinal K. Sanyal","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510","From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035483978","display_name":"C. Brami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Charles J. Brami","raw_affiliation_strings":["From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079520841","display_name":"Paul Bischof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Paul Bischof","raw_affiliation_strings":["The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068061148","display_name":"Edwina Simmons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Edwina Simmons","raw_affiliation_strings":["From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062683181","display_name":"Eytan R. Barnea","orcid":"https://orcid.org/0000-0003-4677-4370","observed_orcids":["https://orcid.org/0000-0003-4677-4370"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Eytan R. Barnea","raw_affiliation_strings":["From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John M. Dwyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"John M. Dwyer","raw_affiliation_strings":["From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030184373","display_name":"Frederick Nicholas Naftolin","orcid":"https://orcid.org/0000-0002-9447-6266","observed_orcids":["https://orcid.org/0000-0002-9447-6266"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Frederick Naftolin","raw_affiliation_strings":["From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Obstetrics and Gynecology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"The Department of Obstetrics and Gynecology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109320361"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5410,"currency":"USD","value_usd":5410},"apc_paid":{"value":5410,"currency":"USD","value_usd":5410},"fwci":0.5999,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.65351582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"161","issue":"2","first_page":"446","last_page":"453"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trophoblast","display_name":"trophoblast","score":0.8669999837875366},{"id":"https://openalex.org/keywords/first-trimester-placenta","display_name":"first trimester placenta","score":0.6970000267028809},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8560000061988831},{"id":"https://openalex.org/keywords/papp-a","display_name":"PAPP-A","score":0.9800000190734863},{"id":"https://openalex.org/keywords/suppressor-lymphocytes","display_name":"suppressor lymphocytes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/bewo-cells","display_name":"BeWo cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fetal-allograft-tolerance","display_name":"fetal allograft tolerance","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.924338698387146},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.497513085603714},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.49091464281082153},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4663611650466919},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4658798575401306},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4489714503288269},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4470342695713043},{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.4405992329120636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43582767248153687},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4314901530742645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.406482070684433},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.37954187393188477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3532223105430603},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.3078290820121765},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2975728213787079},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011266","descriptor_name":"Pregnancy-Associated Plasma Protein-A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018997","descriptor_name":"Chorionic Gonadotropin, beta Subunit, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0002-9378(89)90540-1","doi":"https://doi.org/10.1016/0002-9378(89)90540-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0002-9378(89)90540-1","pdf_url":"https://doi.org/10.1016/0002-9378(89)90540-1","source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},{"id":"pmid:2475020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2475020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of obstetrics and gynecology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0002-9378(89)90540-1","doi":"https://doi.org/10.1016/0002-9378(89)90540-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0002-9378(89)90540-1","pdf_url":"https://doi.org/10.1016/0002-9378(89)90540-1","source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4518458713","display_name":null,"funder_award_id":"HD-14587","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7709760903","display_name":null,"funder_award_id":"RR 5358","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2029106536.pdf","grobid_xml":"https://content.openalex.org/works/W2029106536.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1509916102","https://openalex.org/W1591370994","https://openalex.org/W1606088136","https://openalex.org/W1941412517","https://openalex.org/W1964259693","https://openalex.org/W1967368175","https://openalex.org/W1984891135","https://openalex.org/W1991293315","https://openalex.org/W1995586078","https://openalex.org/W2041364299","https://openalex.org/W2041459582","https://openalex.org/W2107446636","https://openalex.org/W2407085937","https://openalex.org/W2408999936","https://openalex.org/W2411405470","https://openalex.org/W2742372713","https://openalex.org/W2990355827"],"related_works":["https://openalex.org/W1556106767","https://openalex.org/W1976059227","https://openalex.org/W2088997223","https://openalex.org/W1590522129","https://openalex.org/W2010399527","https://openalex.org/W298225430","https://openalex.org/W2030720141","https://openalex.org/W2033622915","https://openalex.org/W2104123200","https://openalex.org/W2044322289"],"abstract_inverted_index":{"Supernatants":[0],"from":[1,9,170],"isolated":[2],"trophoblast":[3,47,71,119,145,166,220],"cell":[4,149],"cultures":[5],"(trophoblastic":[6],"fluid)":[7],"derived":[8],"first-trimester":[10,171],"human":[11,43],"placentas":[12,169],"were":[13],"assessed":[14],"for":[15,59,190],"immunoregulatory":[16,127,228],"activity.":[17],"Trophoblastic":[18],"fluid":[19,57,103,212],"at":[20,105],"different":[21],"days":[22],"of":[23,30,42,68,88,93,113,129,141,156,164,168,178,181,195,201,205,230],"culture":[24,56,66,86,122,139,150,162],"consistently":[25],"inhibited":[26],"the":[27,55,60,65,85,125,130,138,147,176,199,219,226,231],"blast":[28],"transformation":[29],"allogenic":[31],"lymphocytes.":[32,183],"This":[33,184],"suppressor":[34,182],"effect":[35,128,134,185],"had":[36,152],"no":[37],"apparent":[38],"correlation":[39],"with":[40],"biosynthesis":[41],"chorionic":[44],"gonadotropin":[45],"by":[46,118,218],"cells,":[48],"since":[49],"this":[50],"hormone":[51],"was":[52,82,135],"secreted":[53,217],"into":[54],"only":[58],"initial":[61],"3":[62],"days.":[63,90],"However,":[64],"fluids":[67,140,151],"such":[69,215],"purified":[70],"cells":[72,120,167,221],"contained":[73],"an":[74],"immunosuppressive":[75,133,196],"factor,":[76],"pregnancy-associated":[77,94,114,157,206],"plasma":[78,95,115,158,207],"protein":[79,96,116,159,208],"A,":[80],"which":[81],"measurable":[83],"throughout":[84],"period":[87],"8":[89],"The":[91,161],"presence":[92,200],"A":[97,117,209],"in":[98,101,121,137,174,210,225],"significant":[99],"amounts":[100],"trophoblastic":[102,211],"collected":[104],"daily":[106],"intervals":[107],"indicated":[108],"a":[109,179],"continuous":[110],"secretion":[111],"ability":[112],"parallel":[123],"to":[124],"suppressive":[126],"fluid.":[131],"Such":[132],"absent":[136],"control":[142],"BeWo":[143,148],"malignant":[144],"cells;":[146],"markedly":[153],"reduced":[154],"levels":[155,204],"A.":[160],"supernatant":[163],"normal":[165],"pregnancy":[172],"activated":[173],"vitro":[175],"generation":[177],"population":[180],"is":[186],"generally":[187],"considered":[188],"responsible":[189],"immunologic":[191],"tolerance.":[192],"Therefore":[193],"demonstration":[194],"effects":[197],"and":[198],"relatively":[202],"high":[203],"indicate":[213],"that":[214],"proteins":[216],"may":[222],"be":[223],"important":[224],"local":[227],"processes":[229],"fetal":[232],"allograft.":[233]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
