{"id":"https://openalex.org/W2029083568","doi":"https://doi.org/10.1076/soph.18.3.116.29813","title":"Pars plana vitrectomy for refractory diabetic macular edema","display_name":"Pars plana vitrectomy for refractory diabetic macular edema","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2029083568","doi":"https://doi.org/10.1076/soph.18.3.116.29813","mag":"2029083568","pmid":"https://pubmed.ncbi.nlm.nih.gov/15513471"},"language":"en","primary_location":{"id":"doi:10.1076/soph.18.3.116.29813","doi":"https://doi.org/10.1076/soph.18.3.116.29813","is_oa":false,"landing_page_url":"https://doi.org/10.1076/soph.18.3.116.29813","pdf_url":null,"source":{"id":"https://openalex.org/S118649763","display_name":"Seminars in Ophthalmology","issn_l":"0882-0538","issn":["0882-0538","1744-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059405356","display_name":"R.A. Grigorian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben Grigorian","raw_affiliation_strings":["Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA","Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark 01701-1709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark 01701-1709, USA","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082151459","display_name":"Neelakshi Bhagat","orcid":"https://orcid.org/0000-0003-2187-3145","observed_orcids":["https://orcid.org/0000-0003-2187-3145"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelakshi Bhagat","raw_affiliation_strings":["Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036443714","display_name":"Paolo Lanzetta","orcid":"https://orcid.org/0000-0003-3746-141X","observed_orcids":["https://orcid.org/0000-0003-3746-141X"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo Lanzetta","raw_affiliation_strings":["Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071117547","display_name":"Arthur Tutela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Tutela","raw_affiliation_strings":["Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058961724","display_name":"Marco A. Zarbin","orcid":"https://orcid.org/0000-0002-7811-7132","observed_orcids":["https://orcid.org/0000-0002-7811-7132"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Zarbin","raw_affiliation_strings":["Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology and Visual Science, New Jersey Medical School, Newark, NJ, USA","institution_ids":["https://openalex.org/I4402554120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4402554120"],"apc_list":null,"apc_paid":null,"fwci":0.2301,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.25757576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"3","first_page":"116","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.09189999848604202,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pars-plana-vitrectomy","display_name":"pars plana vitrectomy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/refractory-diabetic-macular-edema","display_name":"refractory diabetic macular edema","score":0.9229999780654907},{"id":"https://openalex.org/keywords/internal-limiting-membrane-peeling","display_name":"internal limiting membrane peeling","score":0.9900000095367432},{"id":"https://openalex.org/keywords/laser-photocoagulation","display_name":"laser photocoagulation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/visual-acuity-outcomes","display_name":"visual acuity outcomes","score":0.6819999814033508},{"id":"https://openalex.org/keywords/retinal-edema","display_name":"retinal edema","score":0.699999988079071},{"id":"https://openalex.org/keywords/surgical-complications","display_name":"surgical complications","score":0.7369999885559082},{"id":"https://openalex.org/keywords/rubeosis-iridis","display_name":"rubeosis iridis","score":0.902999997138977},{"id":"https://openalex.org/keywords/macular-hole","display_name":"macular hole","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9579914808273315},{"id":"https://openalex.org/C2777063560","wikidata":"https://www.wikidata.org/wiki/Q3366043","display_name":"Pars plana","level":4,"score":0.9417201280593872},{"id":"https://openalex.org/C2781242345","wikidata":"https://www.wikidata.org/wiki/Q924295","display_name":"Vitrectomy","level":3,"score":0.9296393394470215},{"id":"https://openalex.org/C2985127711","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic macular edema","level":4,"score":0.8783438205718994},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7354769110679626},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7049353122711182},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5420911908149719},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.5325839519500732},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3598260283470154},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.1854584515094757},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D014821","descriptor_name":"Vitrectomy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014821","descriptor_name":"Vitrectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1076/soph.18.3.116.29813","doi":"https://doi.org/10.1076/soph.18.3.116.29813","is_oa":false,"landing_page_url":"https://doi.org/10.1076/soph.18.3.116.29813","pdf_url":null,"source":{"id":"https://openalex.org/S118649763","display_name":"Seminars in Ophthalmology","issn_l":"0882-0538","issn":["0882-0538","1744-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Ophthalmology","raw_type":"journal-article"},{"id":"doi:10.1080/08820530390899141","doi":"https://doi.org/10.1080/08820530390899141","is_oa":false,"landing_page_url":"https://doi.org/10.1080/08820530390899141","pdf_url":null,"source":{"id":"https://openalex.org/S118649763","display_name":"Seminars in Ophthalmology","issn_l":"0882-0538","issn":["0882-0538","1744-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Ophthalmology","raw_type":"journal-article"},{"id":"pmid:15513471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15513471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:alma.01RUT_INST:11665200070004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Pars-plana-vitrectomy-for-refractory-diabetic/991031666178304646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:air.uniud.it:11390/671124","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11390/671124","pdf_url":null,"source":{"id":"https://openalex.org/S4306401163","display_name":"Institutional Research Information System (University of Udine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129043915","host_organization_name":"University of Udine","host_organization_lineage":["https://openalex.org/I129043915"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320312354","display_name":"\u00d6gonfonden","ror":"https://ror.org/00n58s174"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W155801435","https://openalex.org/W206358272","https://openalex.org/W1480702754","https://openalex.org/W1514680602","https://openalex.org/W1828237247","https://openalex.org/W1964233473","https://openalex.org/W1965150721","https://openalex.org/W1966639390","https://openalex.org/W1972506234","https://openalex.org/W1988246313","https://openalex.org/W2000552582","https://openalex.org/W2001453091","https://openalex.org/W2012015161","https://openalex.org/W2016138786","https://openalex.org/W2024301850","https://openalex.org/W2028436295","https://openalex.org/W2032638607","https://openalex.org/W2039520399","https://openalex.org/W2039746455","https://openalex.org/W2040110751","https://openalex.org/W2043864349","https://openalex.org/W2045426295","https://openalex.org/W2046078823","https://openalex.org/W2049904087","https://openalex.org/W2057600912","https://openalex.org/W2060207361","https://openalex.org/W2061517280","https://openalex.org/W2078734403","https://openalex.org/W2080699440","https://openalex.org/W2082946025","https://openalex.org/W2091598664","https://openalex.org/W2107482685","https://openalex.org/W2112689098","https://openalex.org/W2112951629","https://openalex.org/W2413793785","https://openalex.org/W2546961712","https://openalex.org/W2594592726","https://openalex.org/W2771472252","https://openalex.org/W4233230329","https://openalex.org/W4240172601","https://openalex.org/W6821827789"],"related_works":["https://openalex.org/W4410721390","https://openalex.org/W2147409211","https://openalex.org/W3010912908","https://openalex.org/W1506619540","https://openalex.org/W2028752079","https://openalex.org/W4327576527","https://openalex.org/W4282025488","https://openalex.org/W3096067062","https://openalex.org/W1021201312","https://openalex.org/W2418424808"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,36],"aim":[2],"of":[3,11,24,41,59,79,89,99,108],"this":[4],"study":[5],"is":[6,62],"to":[7,64,157],"describe":[8],"the":[9,25,57,136],"results":[10],"pars":[12],"plana":[13,145],"vitrectomy":[14,146],"(PPV)":[15],"for":[16,56,152],"refractory":[17,156],"diabetic":[18,153],"macular":[19,122,154],"edema":[20,92,155],"(DME).":[21],"METHODS:":[22],"Review":[23],"relevant":[26],"peer-reviewed":[27],"scientific":[28],"literature":[29],"identified":[30],"using":[31],"Medline.":[32],"MAIN":[33],"OUTCOME":[34],"MEASURES:":[35],"anatomical":[37],"and":[38,124,135],"functional":[39],"outcome":[40],"surgery.":[42],"RESULTS:":[43],"Vitrectomy":[44],"with":[45,81,105],"or":[46,67,87,94],"without":[47],"internal":[48],"limiting":[49],"membrane":[50],"(ILM)":[51],"peeling":[52],"can":[53,147],"be":[54,148],"beneficial":[55],"treatment":[58,151],"DME":[60],"that":[61],"resistant":[63],"laser":[65,158],"photocoagulation":[66],"sub-Tenon's":[68,161],"steroid":[69,163],"injection.":[70,164],"Visual":[71],"improvement":[72,86],"has":[73],"been":[74,141],"reported":[75],"in":[76,96,103],"approximately":[77,82,97,106,114,119,125],"40-90%":[78],"patients,":[80],"85-100%":[83],"experiencing":[84],"either":[85],"stabilization":[88],"vision.":[90],"Retinal":[91],"decreases":[93],"resolves":[95],"70-100%":[98],"patients.":[100],"Complications":[101],"range":[102],"severity":[104],"5-20%":[107],"patients":[109],"developing":[110,116,121,127],"peripheral":[111],"retinal":[112,117],"breaks,":[113],"1-2%":[115],"detachment,":[118],"2%":[120],"hole,":[123],"10-60%":[126],"cataract.":[128],"Severe":[129],"complications":[130],"such":[131],"as":[132],"rubeosis":[133],"iridis":[134],"fibrinoid":[137],"syndrome":[138],"have":[139],"also":[140],"reported.":[142],"CONCLUSION:":[143],"Pars":[144],"an":[149],"effective":[150],"therapy":[159],"and/or":[160],"capsule":[162]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}