{"id":"https://openalex.org/W2029068605","doi":"https://doi.org/10.1371/journal.pone.0047744","title":"Genetic KCa3.1-Deficiency Produces Locomotor Hyperactivity and Alterations in Cerebral Monoamine Levels","display_name":"Genetic KCa3.1-Deficiency Produces Locomotor Hyperactivity and Alterations in Cerebral Monoamine Levels","publication_year":2012,"publication_date":"2012-10-15","ids":{"openalex":"https://openalex.org/W2029068605","doi":"https://doi.org/10.1371/journal.pone.0047744","mag":"2029068605","pmid":"https://pubmed.ncbi.nlm.nih.gov/23077667","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3471871"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0047744","doi":"https://doi.org/10.1371/journal.pone.0047744","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0047744","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0047744&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0047744&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018056521","display_name":"Kate Lykke Lambertsen","orcid":"https://orcid.org/0000-0001-9276-4902","observed_orcids":["https://orcid.org/0000-0001-9276-4902"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kate Lykke Lambertsen","raw_affiliation_strings":["Department of Neurobiology Research, University of Southern Demark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, University of Southern Demark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078615730","display_name":"Jan Bert Gramsbergen","orcid":"https://orcid.org/0000-0002-2032-5123","observed_orcids":["https://orcid.org/0000-0002-2032-5123"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jan Bert Gramsbergen","raw_affiliation_strings":["Department of Neurobiology Research, University of Southern Demark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, University of Southern Demark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025937162","display_name":"Mithula Sivasaravanaparan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mithula Sivasaravanaparan","raw_affiliation_strings":["Department of Neurobiology Research, University of Southern Demark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, University of Southern Demark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044105481","display_name":"Nicholas Ditzel","orcid":"https://orcid.org/0000-0003-0675-8915","observed_orcids":["https://orcid.org/0000-0003-0675-8915"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nicholas Ditzel","raw_affiliation_strings":["KMEB, Molecular Endocrinology, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KMEB, Molecular Endocrinology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102238672","display_name":"Linda Sevelsted M\u00f8ller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Linda Maria Sevelsted-M\u00f8ller","raw_affiliation_strings":["Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052324021","display_name":"Aida Oliv\u00e1n\u2010Viguera","orcid":"https://orcid.org/0000-0001-5348-924X","observed_orcids":["https://orcid.org/0000-0001-5348-924X"]},"institutions":[{"id":"https://openalex.org/I4210085944","display_name":"Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo","ror":"https://ror.org/007bpwb04","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210085944"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aida Oliv\u00e1n-Viguera","raw_affiliation_strings":["Aragon Institute of Health Sciences I+CS and ARAID, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aragon Institute of Health Sciences I+CS and ARAID, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210085944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012127212","display_name":"Maj Rabjerg","orcid":"https://orcid.org/0000-0002-6266-7906","observed_orcids":["https://orcid.org/0000-0002-6266-7906"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maj Rabjerg","raw_affiliation_strings":["Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026660883","display_name":"Heike Wulff","orcid":"https://orcid.org/0000-0003-4437-5763","observed_orcids":["https://orcid.org/0000-0003-4437-5763"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heike Wulff","raw_affiliation_strings":["Department of Pharmacology, University of California Davis, Davis, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California Davis, Davis, California, United States of America","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061674579","display_name":"Ralf K\u00f6hler","orcid":"https://orcid.org/0000-0001-9563-2913","observed_orcids":["https://orcid.org/0000-0001-9563-2913"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I4210085944","display_name":"Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo","ror":"https://ror.org/007bpwb04","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210085944"]}],"countries":["DK","ES"],"is_corresponding":true,"raw_author_name":"Ralf K\u00f6hler","raw_affiliation_strings":["Aragon Institute of Health Sciences I+CS and ARAID, Zaragoza, Spain","Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aragon Institute of Health Sciences I+CS and ARAID, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210085944"]},{"raw_affiliation_string":"Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061674579"],"corresponding_institution_ids":["https://openalex.org/I177969490","https://openalex.org/I4210085944"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.6057,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.82461681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"10","first_page":"e47744","last_page":"e47744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kca3-1","display_name":"KCa3.1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ska-31","display_name":"SKA-31","score":0.8230000138282776},{"id":"https://openalex.org/keywords/genetic-deficiency","display_name":"genetic deficiency","score":0.4819999933242798},{"id":"https://openalex.org/keywords/locomotor-hyperactivity","display_name":"locomotor hyperactivity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/serotonin-turnover","display_name":"serotonin turnover","score":0.9769999980926514},{"id":"https://openalex.org/keywords/noradrenaline-turnover","display_name":"noradrenaline turnover","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.5730000138282776},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/monoaminergic-neurotransmission","display_name":"monoaminergic neurotransmission","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.7411554455757141},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37849724292755127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35242289304733276},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3302130103111267},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.323735773563385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3008996248245239},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.2725818455219269},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051660","descriptor_name":"Intermediate-Conductance Calcium-Activated Potassium Channels","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D051660","descriptor_name":"Intermediate-Conductance Calcium-Activated Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051660","descriptor_name":"Intermediate-Conductance Calcium-Activated Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0047744","doi":"https://doi.org/10.1371/journal.pone.0047744","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0047744","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0047744&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3471871","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3471871","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23077667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23077667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8954d4c7","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8954d4c7","pdf_url":"https://escholarship.org/content/qt8954d4c7/qt8954d4c7.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE, vol 7, iss 10","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.796.8103","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.796.8103","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/cb/f1/pone.0047744.PMC3471871.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0fad14b82d2e47bda172ff3266e8e9bb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0fad14b82d2e47bda172ff3266e8e9bb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 10, p e47744 (2012)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8954d4c7","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8954d4c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS one, vol 7, iss 10","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/118655","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Genetic_KCa3_1_Deficiency_Produces_Locomotor_Hyperactivity_and_Alterations_in_Cerebral_Monoamine_Levels/118655","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/1bc8bb86-581e-4608-8184-2a25094211a8","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/1bc8bb86-581e-4608-8184-2a25094211a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lambertsen, K L, Gramsbergen, J B, Sivasaravanaparan, M, Ditzel, N, M\u00f8ller, L M S, Oliv\u00e1n-Viguera, A, Rabjerg, M, Wulff, H & K\u00f6hler, R 2012, 'Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels', PLOS ONE, vol. 7, no. 10, pp. e47744. https://doi.org/10.1371/journal.pone.0047744","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0047744","doi":"https://doi.org/10.1371/journal.pone.0047744","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0047744","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0047744&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4848096987","display_name":"The microglial potassium channels Kv1.3 and KCa3.1 as therapeutic targets for neu","funder_award_id":"R01GM076063","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G88439039","display_name":"Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs","funder_award_id":"R21NS072585","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321504","display_name":"Carlsbergfondet","ror":"https://ror.org/01kpjmx04"},{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2029068605.pdf","grobid_xml":"https://content.openalex.org/works/W2029068605.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1541948917","https://openalex.org/W1976461271","https://openalex.org/W1977475418","https://openalex.org/W1978356252","https://openalex.org/W1993271363","https://openalex.org/W1994434757","https://openalex.org/W1996333163","https://openalex.org/W2006786639","https://openalex.org/W2006957980","https://openalex.org/W2009396930","https://openalex.org/W2011588834","https://openalex.org/W2011801743","https://openalex.org/W2020477012","https://openalex.org/W2021935429","https://openalex.org/W2027841061","https://openalex.org/W2028851302","https://openalex.org/W2032019404","https://openalex.org/W2033841097","https://openalex.org/W2033908484","https://openalex.org/W2035551416","https://openalex.org/W2037587275","https://openalex.org/W2042670053","https://openalex.org/W2044495359","https://openalex.org/W2051040059","https://openalex.org/W2053546226","https://openalex.org/W2060331633","https://openalex.org/W2078261825","https://openalex.org/W2080794328","https://openalex.org/W2083048709","https://openalex.org/W2090851491","https://openalex.org/W2099017042","https://openalex.org/W2106607972","https://openalex.org/W2109279225","https://openalex.org/W2114130324","https://openalex.org/W2115263803","https://openalex.org/W2118584840","https://openalex.org/W2122289819","https://openalex.org/W2125546821","https://openalex.org/W2127961228","https://openalex.org/W2137435338","https://openalex.org/W2156578605","https://openalex.org/W2157952220","https://openalex.org/W2162084860","https://openalex.org/W2168251051","https://openalex.org/W2235476089","https://openalex.org/W2276578412"],"related_works":["https://openalex.org/W2122289819","https://openalex.org/W2120162713","https://openalex.org/W1998781002","https://openalex.org/W2018823145","https://openalex.org/W2028273247","https://openalex.org/W2285413752","https://openalex.org/W2069466416","https://openalex.org/W1968370453","https://openalex.org/W1971104810","https://openalex.org/W1567469337"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,231],"calmodulin/calcium-activated":[2],"K(+)":[3],"channel":[4],"KCa3.1":[5,46,222],"is":[6,34],"expressed":[7],"in":[8,53,84,114,127,157,161,171,184,194,198,210,229],"red":[9],"and":[10,15,17,20,32,49,75,96,118,138,154,188,206,226],"white":[11],"blood":[12],"cells,":[13],"epithelia":[14],"endothelia,":[16],"possibly":[18],"central":[19],"peripheral":[21],"neurons.":[22],"However,":[23],"our":[24],"knowledge":[25],"about":[26],"its":[27],"contribution":[28],"to":[29,224,240],"neurological":[30],"functions":[31,98],"behavior":[33,48,156,225],"incomplete.":[35],"Here,":[36],"we":[37],"investigated":[38],"whether":[39],"genetic":[40],"deficiency":[41],"or":[42],"pharmacological":[43,246],"activation":[44],"of":[45,73,80,110,145,148,173,176,221,234,251],"change":[47],"cerebral":[50],"monoamine":[51,208],"levels":[52,140,209],"mice.":[54,200,230],"METHODOLOGY/PRINCIPAL":[55],"FINDINGS:":[56],"In":[57,101],"the":[58,85,94,128,149,174,238,249],"open":[59],"field":[60],"test,":[61],"KCa3.1-deficiency":[62,202],"increased":[63,126],"horizontal":[64],"activity,":[65],"as":[66,244],"KCa3.1(-/-)":[67,102,162,179,199],"mice":[68,180],"travelled":[69],"longer":[70],"distances":[71],"(\u2248145%":[72],"KCa3.1(+/+))":[74],"at":[76],"higher":[77],"speed":[78],"(\u22481.5-fold":[79],"KCa3.1(+/+)).":[81],"Working":[82],"memory":[83],"Y-maze":[86],"was":[87],"reduced":[88,113,152,190],"by":[89],"KCa3.1-deficiency.":[90],"Motor":[91],"coordination":[92],"on":[93],"rotarod":[95],"neuromuscular":[97],"were":[99,112,125,134,141,181],"unchanged.":[100],"mice,":[103,163],"HPLC":[104],"analysis":[105],"revealed":[106],"that":[107],"turn-over":[108,123,132],"rates":[109,124,133],"serotonin":[111],"frontal":[115,129],"cortex,":[116],"striatum":[117],"brain":[119,212],"stem,":[120],"while":[121,164],"noradrenalin":[122],"cortex.":[130],"Dopamine":[131],"unaltered.":[135,142],"Plasma":[136],"catecholamine":[137],"corticosterone":[139],"Intraperitoneal":[143],"injections":[144],"10":[146],"mg/kg":[147,166],"KCa3.1/KCa2-activator":[150],"SKA-31":[151,167,236],"rearing":[153],"turning":[155],"KCa3.1(+/+)":[158,195],"but":[159,196],"not":[160,197],"30":[165],"caused":[168],"strong":[169],"sedation":[170],"50%":[172],"animals":[175],"either":[177],"genotypes.":[178],"hyperactive":[182],"(\u2248+60%)":[183],"their":[185],"home":[186],"cage":[187],"SKA-31-administration":[189],"nocturnal":[191],"physical":[192],"activity":[193],"CONCLUSIONS/SIGNIFICANCE:":[201],"causes":[203],"locomotor":[204],"hyperactivity":[205,253],"altered":[207],"selected":[211],"regions,":[213],"suggesting":[214],"a":[215],"so":[216],"far":[217],"unknown":[218],"functional":[219],"link":[220],"channels":[223,243],"monoaminergic":[227],"neurotransmission":[228],"tranquilizing":[232],"effects":[233],"low-dose":[235],"raise":[237],"possibility":[239],"use":[241],"KCa3.1/KCa2":[242],"novel":[245],"targets":[247],"for":[248],"treatment":[250],"neuropsychiatric":[252],"disorders.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
