{"id":"https://openalex.org/W2028994274","doi":"https://doi.org/10.1055/s-2007-979933","title":"Effects of Continuous and Pulsatile Administration of Pituitary Rat Thyrotropin and Recombinant Human Thyrotropin in a Chronically Cannulated Rat","display_name":"Effects of Continuous and Pulsatile Administration of Pituitary Rat Thyrotropin and Recombinant Human Thyrotropin in a Chronically Cannulated Rat","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W2028994274","doi":"https://doi.org/10.1055/s-2007-979933","mag":"2028994274","pmid":"https://pubmed.ncbi.nlm.nih.gov/7750899"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-979933","doi":"https://doi.org/10.1055/s-2007-979933","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-979933","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030146202","display_name":"Holger Leitolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Leitolf","raw_affiliation_strings":["Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031319152","display_name":"Mariusz W. Szkudlinski","orcid":"https://orcid.org/0000-0002-5656-2104","observed_orcids":["https://orcid.org/0000-0002-5656-2104"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Szkudlinski","raw_affiliation_strings":["Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110338423","display_name":"C Hoang-Vu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Hoang-Vu","raw_affiliation_strings":["Abteilung Klinische Endokrinologie, Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung Klinische Endokrinologie, Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032350044","display_name":"NAGESWARA RAO THOTAKURA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Thotakura","raw_affiliation_strings":["Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109289328","display_name":"A. von zur M\u00fchlen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. von zur M\u00fchlen","raw_affiliation_strings":["Abteilung Klinische Endokrinologie, Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung Klinische Endokrinologie, Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015947439","display_name":"Georg E. Brabant","orcid":"https://orcid.org/0000-0001-8532-7632","observed_orcids":["https://orcid.org/0000-0001-8532-7632","https://orcid.org/0000-0002-0923-7763"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Brabant","raw_affiliation_strings":["Abteilung Klinische Endokrinologie, Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung Klinische Endokrinologie, Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108610151","display_name":"B D Weintraub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Weintraub","raw_affiliation_strings":["Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3151,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78984811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"27","issue":"04","first_page":"173","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/recombinant-human-thyrotropin","display_name":"recombinant human thyrotropin","score":0.8880000114440918},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.8019999861717224},{"id":"https://openalex.org/keywords/thyroid-hormone-secretion","display_name":"thyroid hormone secretion","score":0.7789999842643738},{"id":"https://openalex.org/keywords/thyroid-stimulation","display_name":"thyroid stimulation","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.8492193222045898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8411186933517456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8122684955596924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6055981516838074},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5838027000427246},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.49495643377304077},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.47029659152030945},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4635232090950012},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.4550895690917969}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004326","descriptor_name":"Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2007-979933","doi":"https://doi.org/10.1055/s-2007-979933","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-979933","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},{"id":"pmid:7750899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7750899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047277961","https://openalex.org/W2057661082","https://openalex.org/W2009564666","https://openalex.org/W2128232060","https://openalex.org/W2036220966","https://openalex.org/W1987582255","https://openalex.org/W1967426802","https://openalex.org/W2092613703","https://openalex.org/W2025690640","https://openalex.org/W2055941401"],"abstract_inverted_index":{"Pulsatile":[0],"secretion":[1],"of":[2,27,32,45,48,72,120,130,146,152,173,177,203,211,216,287,291,300,310],"thyrotropin":[3,49],"(TSH)":[4],"is":[5],"a":[6,24,68,117,142,166,223,261,268],"well":[7],"characterized":[8],"phenomenon":[9],"in":[10,36,181,189,229,249,267,271,274,297],"the":[11,37,73,178,230,235,250],"human,":[12],"yet":[13],"only":[14],"limited":[15],"data":[16,282],"are":[17],"available":[18],"from":[19],"animal":[20],"studies.":[21],"We":[22],"propose":[23],"combined":[25],"model":[26],"chronic":[28],"catheterization":[29],"and":[30,116,122,136,139,200,207,225,240],"suppression":[31],"endogenous":[33],"TSH":[34,75,94,112,125,175,288],"release":[35,312],"rat":[38,74],"allowing":[39],"us":[40],"to":[41,92,141,158,170,183,219,234,276,296],"apply":[42],"quantified":[43],"pulses":[44],"different":[46],"preparations":[47],"intravenously":[50],"with":[51,54,61,110,294],"minimal":[52],"interference":[53],"endogenously":[55],"produced":[56],"hormone.":[57],"Sprague-Dawley":[58],"rats":[59],"treated":[60],"drinking":[62],"water":[63],"containing":[64],"3,5,3\u2032-triiodothyronine":[65],"(T3)":[66],"showed":[67,222],"significant":[69],"6-fold":[70,226],"decrease":[71,270],"(rTSH)":[76],"level":[77,100],"after":[78,134,150,198,208,238,257,278],"four":[79,137,191],"days.":[80],"Free":[81],"thyroxine":[82],"(FT4)":[83],"levels":[84,273],"were":[85,127,132,196],"9-fold":[86],"below":[87],"unsuppressed":[88],"levels;":[89],"FT4":[90,131,162,217,272],"response":[91,228],"exogenous":[93],"application":[95,286],"above":[96],"this":[97,311],"suppressed":[98],"baseline":[99],"was":[101,154,246],"selected":[102],"as":[103,169],"an":[104,306],"endpoint.":[105],"Infusion":[106],"studies":[107],"compared":[108,133,233],"pulsatile":[109,174,231,264,285],"continuous":[111,184,236,279],"administration.":[113],"A":[114],"low":[115,212,239,253],"high":[118,144,204,241,258],"dose":[119],"rTSH":[121,147,205,220,242],"recombinant":[123],"human":[124],"(rec-hTSH)":[126],"administered.":[128],"Levels":[129],"two":[135],"days":[138,202,210],"responsiveness":[140],"standard":[143],"bolus":[145,262],"6":[148],"h":[149],"end":[151],"infusion":[153,206,265],"assessed.":[155],"With":[156],"regard":[157,295],"its":[159],"potency":[160],"for":[161],"release,":[163],"differences":[164],"indicating":[165],"general":[167],"trend":[168],"superior":[171,292],"efficiency":[172,293],"stimulation":[176,185,299],"thyroid":[179,301],"gland":[180],"comparison":[182,275],"could":[186],"be":[187,290],"observed":[188,248],"all":[190],"experiments.":[192],"More":[193],"pronounced":[194],"effects":[195],"seen":[197],"2":[199],"4":[201,209],"rec-hTSH":[213,254,259],"infusion.":[214,255],"Comparison":[215],"responses":[218],"boli":[221],"2-":[224],"higher":[227],"group":[232,237],"infusion,":[243,260],"respectively.":[244],"This":[245],"not":[247],"animals":[251],"receiving":[252],"However,":[256],"following":[263],"resulted":[266],"lesser":[269],"that":[277,284],"application.":[280],"Our":[281],"suggest":[283],"might":[289],"vivo":[298],"hormone":[302],"secretion,":[303],"hence":[304],"suggesting":[305],"underlying":[307],"physiological":[308],"significance":[309],"pattern.":[313]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}