{"id":"https://openalex.org/W2028949865","doi":"https://doi.org/10.1016/j.exppara.2014.06.017","title":"Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection","display_name":"Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection","publication_year":2014,"publication_date":"2014-07-02","ids":{"openalex":"https://openalex.org/W2028949865","doi":"https://doi.org/10.1016/j.exppara.2014.06.017","mag":"2028949865","pmid":"https://pubmed.ncbi.nlm.nih.gov/24996067"},"language":"en","primary_location":{"id":"doi:10.1016/j.exppara.2014.06.017","doi":"https://doi.org/10.1016/j.exppara.2014.06.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.exppara.2014.06.017","pdf_url":null,"source":{"id":"https://openalex.org/S102868315","display_name":"Experimental Parasitology","issn_l":"0014-4894","issn":["0014-4894","1090-2449"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103179897","display_name":"Yan-Rong Yu","orcid":"https://orcid.org/0000-0002-1025-9409","observed_orcids":["https://orcid.org/0000-0002-1025-9409"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan-Rong Yu","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: yuyr@bjmu.edu.cn","Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: yuyr@bjmu.edu.cn","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102129021","display_name":"Mingjun Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116534","display_name":"Shandong Entry-Exit Inspection and Quarantine Bureau","ror":"https://ror.org/01tqkhn82","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210116534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Jun Deng","raw_affiliation_strings":["Technical Center of Shandong Entry-Exit Inspection and Quarantine Bureau, Qingdao 266002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technical Center of Shandong Entry-Exit Inspection and Quarantine Bureau, Qingdao 266002, China","institution_ids":["https://openalex.org/I4210116534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044621476","display_name":"Weiwei Lu","orcid":"https://orcid.org/0000-0002-1982-390X","observed_orcids":["https://orcid.org/0000-0002-1982-390X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Wei Lu","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714818","display_name":"Jinsheng Zhang","orcid":"https://orcid.org/0009-0008-5752-0871","observed_orcids":["https://orcid.org/0009-0008-5752-0871"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Sheng Zhang","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037072011","display_name":"Mo-Zhi Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mo-Zhi Jia","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052994285","display_name":"Jie Sheng Huang","orcid":"https://orcid.org/0000-0003-3842-6181","observed_orcids":["https://orcid.org/0000-0003-3842-6181"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Huang","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035978001","display_name":"Yongfen Qi","orcid":"https://orcid.org/0000-0001-6514-0491","observed_orcids":["https://orcid.org/0000-0001-6514-0491"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong-Fen Qi","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Laboratory of Bioactive Molecule, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: yongfenqi@163.com","Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China","Laboratory of Bioactive Molecule, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Laboratory of Bioactive Molecule, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: yongfenqi@163.com","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Laboratory of Bioactive Molecule, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035978001","https://openalex.org/A5103179897"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":{"value":3470,"currency":"USD","value_usd":3470},"apc_paid":null,"fwci":1.1455,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.77114135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"145","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.06270000338554382,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichinella-spiralis","display_name":"Trichinella spiralis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/trichinellosis","display_name":"trichinellosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9860000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/intestinal-infection","display_name":"intestinal infection","score":0.6899999976158142},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9359999895095825},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.7889999747276306},{"id":"https://openalex.org/keywords/caspase-12","display_name":"caspase-12","score":0.9229999780654907},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/helminth-infection","display_name":"helminthiasis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2781320125","wikidata":"https://www.wikidata.org/wiki/Q730937","display_name":"Trichinella spiralis","level":3,"score":0.9114348888397217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8609753847122192},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8371418118476868},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7021095752716064},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5802760720252991},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.5774067044258118},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.5111194252967834},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.4517192840576172},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.42251697182655334},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4214402139186859},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41083475947380066},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3514895439147949},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32693424820899963},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2698749005794525},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15538573265075684},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13185444474220276},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.12793570756912231},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014235","descriptor_name":"Trichinellosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017160","descriptor_name":"Trichinella spiralis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053454","descriptor_name":"Caspase 12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.exppara.2014.06.017","doi":"https://doi.org/10.1016/j.exppara.2014.06.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.exppara.2014.06.017","pdf_url":null,"source":{"id":"https://openalex.org/S102868315","display_name":"Experimental Parasitology","issn_l":"0014-4894","issn":["0014-4894","1090-2449"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Parasitology","raw_type":"journal-article"},{"id":"pmid:24996067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24996067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental parasitology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6387724903","display_name":"Toll\u6837\u53d7\u4f53\u5bf9\u65cb\u6bdb\u866b\u65b0\u751f\u5e7c\u866b\u7684\u514d\u75ab\u8c03\u8282\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"30901247","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1559569303","https://openalex.org/W1765185969","https://openalex.org/W1956548801","https://openalex.org/W1967217097","https://openalex.org/W1989382448","https://openalex.org/W1994516121","https://openalex.org/W1995675850","https://openalex.org/W2008711121","https://openalex.org/W2025534153","https://openalex.org/W2028726386","https://openalex.org/W2044392443","https://openalex.org/W2049870850","https://openalex.org/W2069364842","https://openalex.org/W2077604052","https://openalex.org/W2080238599","https://openalex.org/W2085933321","https://openalex.org/W2093087623","https://openalex.org/W2100326161","https://openalex.org/W2103463718","https://openalex.org/W2103532831","https://openalex.org/W2116287730","https://openalex.org/W2133644385","https://openalex.org/W2144153346","https://openalex.org/W2321408000","https://openalex.org/W2472185160"],"related_works":["https://openalex.org/W4214931811","https://openalex.org/W2472185160","https://openalex.org/W2359377080","https://openalex.org/W2364238683","https://openalex.org/W7047429751","https://openalex.org/W4399671796","https://openalex.org/W2307350866","https://openalex.org/W4411194272","https://openalex.org/W1559569303","https://openalex.org/W2021297727"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}