{"id":"https://openalex.org/W2028920396","doi":"https://doi.org/10.1507/endocrj.44.247","title":"Cloning and Characterization of the 4.2kb Region of the Rat Thyrotropin Receptor Promoter.","display_name":"Cloning and Characterization of the 4.2kb Region of the Rat Thyrotropin Receptor Promoter.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2028920396","doi":"https://doi.org/10.1507/endocrj.44.247","mag":"2028920396","pmid":"https://pubmed.ncbi.nlm.nih.gov/9228460"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj.44.247","doi":"https://doi.org/10.1507/endocrj.44.247","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.44.247","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/44/2/44_2_247/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj1993/44/2/44_2_247/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076555403","display_name":"Shoichiro Ikuyama","orcid":"https://orcid.org/0000-0001-5514-2303","observed_orcids":["https://orcid.org/0000-0001-5514-2303"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHOICHIRO IKUYAMA","raw_affiliation_strings":["Third Department of Internal Medicine, Kyushu University Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Kyushu University Faculty of Medicine","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090303297","display_name":"Kenji Ohe","orcid":"https://orcid.org/0000-0002-1958-7572","observed_orcids":["https://orcid.org/0000-0002-1958-7572"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KENJI OHE","raw_affiliation_strings":["Third Department of Internal Medicine, Kyushu University Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Kyushu University Faculty of Medicine","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110010291","display_name":"Ryoichi Takayanagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"RYOICHI TAKAYANAGI","raw_affiliation_strings":["Third Department of Internal Medicine, Kyushu University Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Kyushu University Faculty of Medicine","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113498743","display_name":"Leonard D. Kohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LEONARD D. KOHN","raw_affiliation_strings":["Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113564437","display_name":"Hajime Nawata","orcid":"https://orcid.org/0009-0005-4166-9493","observed_orcids":["https://orcid.org/0009-0005-4166-9493"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HAJIME NAWATA","raw_affiliation_strings":["Third Department of Internal Medicine, Kyushu University Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Kyushu University Faculty of Medicine","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8517,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71865281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"44","issue":"2","first_page":"247","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tsh-receptor","display_name":"TSH receptor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tsh-receptor-gene","display_name":"TSH receptor gene","score":0.7649999856948853},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.6809999942779541},{"id":"https://openalex.org/keywords/5-flanking-region","display_name":"5'-flanking region","score":0.9449999928474426},{"id":"https://openalex.org/keywords/minimal-promoter","display_name":"minimal promoter","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ttf-1","display_name":"TTF-1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/frtl-5-cells","display_name":"FRTL-5 cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5509999990463257},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.8038253784179688},{"id":"https://openalex.org/C2777608072","wikidata":"https://www.wikidata.org/wiki/Q4862366","display_name":"Thyrotropin receptor","level":4,"score":0.7871494889259338},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5019285678863525},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4654313921928406},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4168921709060669},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.400893896818161},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37672412395477295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37337544560432434},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3635069727897644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3537863492965698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30317264795303345},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13139215111732483},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1269034743309021},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.08711689710617065},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.07506376504898071},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.05165219306945801},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074482","descriptor_name":"Thyroid Nuclear Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001482","descriptor_name":"Base Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011989","descriptor_name":"Receptors, Thyrotropin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011989","descriptor_name":"Receptors, Thyrotropin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1507/endocrj.44.247","doi":"https://doi.org/10.1507/endocrj.44.247","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.44.247","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/44/2/44_2_247/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},{"id":"pmid:9228460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9228460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1507/endocrj.44.247","doi":"https://doi.org/10.1507/endocrj.44.247","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.44.247","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/44/2/44_2_247/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028920396.pdf","grobid_xml":"https://content.openalex.org/works/W2028920396.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W19760443","https://openalex.org/W106000010","https://openalex.org/W1496124518","https://openalex.org/W1543679567","https://openalex.org/W1569465625","https://openalex.org/W1588729104","https://openalex.org/W1806360748","https://openalex.org/W1900380445","https://openalex.org/W1964926569","https://openalex.org/W1967557581","https://openalex.org/W1976457107","https://openalex.org/W1980751679","https://openalex.org/W1983302968","https://openalex.org/W1983450941","https://openalex.org/W1996816226","https://openalex.org/W2015502095","https://openalex.org/W2032169084","https://openalex.org/W2032462421","https://openalex.org/W2057129205","https://openalex.org/W2070022384","https://openalex.org/W2088199489","https://openalex.org/W2094542229","https://openalex.org/W2098069596","https://openalex.org/W2142832192","https://openalex.org/W2167652132","https://openalex.org/W2205740461","https://openalex.org/W2314225431"],"related_works":["https://openalex.org/W2070022384","https://openalex.org/W1980751679","https://openalex.org/W2142832192","https://openalex.org/W1967557581","https://openalex.org/W1973861488","https://openalex.org/W2024887041","https://openalex.org/W2059262984","https://openalex.org/W2094542229","https://openalex.org/W1588998681","https://openalex.org/W2055053601"],"abstract_inverted_index":{"We":[0,44],"previously":[1,71,167,305],"identified":[2,306],"an":[3,32],"approximately":[4],"200":[5],"bp":[6,130,173,215,228,240,256],"\"minimal":[7],"promoter\"":[8],"of":[9,35,141,149,192,203,209,263,278,289,298,311],"the":[10,20,24,36,77,83,128,133,147,150,171,188,201,207,213,224,234,250,258,264,273,279,287,290,296,299,308,312],"rat":[11,47],"TSH":[12,204],"receptor":[13],"(TSHR)":[14],"gene":[15,95,281,291],"which":[16,55,158,303],"is":[17],"essential":[18],"for":[19,260,286,307],"promoter":[21,38,78,86,107,123,135,151,198,265,301],"activity.":[22,139,266],"In":[23,175],"present":[25],"study,":[26],"we":[27,70,166,304],"have":[28],"cloned":[29],"and":[30,50,87,100,111,132,226,238,246,254],"characterized":[31],"upstream":[33,276],"region":[34,152,235,251,277,302],"TSHR":[37,280],"to":[39,91,155,223,243],"disclose":[40],"additional":[41],"functional":[42],"element(s).":[43],"screened":[45],"a":[46,52,57,92,182],"genomic":[48],"library":[49],"obtained":[51],"DNA":[53],"fragment":[54,63],"contained":[56],"4.2":[58,84,274],"kb":[59,66,85,275],"5'-flanking":[60],"region.":[61],"This":[62,230],"was":[64,125],"2.5":[65],"longer":[67,134],"than":[68,205],"that":[69,233,249,272],"studied":[72],"(1.7":[73],"kb).":[74],"To":[75],"assess":[76],"activity,":[79],"chimeric":[80,183],"plasmids":[81,104],"containing":[82],"its":[88],"5'-deletions":[89],"ligated":[90],"chloramphenicol":[93],"acetyltransferase":[94],"were":[96,185],"transfected":[97],"into":[98],"thyroid":[99,113,142],"non-thyroid":[101],"cells.":[102,120],"These":[103,267],"expressed":[105,126,136,196,217],"significant":[106],"activity":[108,124,148,199,220],"in":[109,117,187,200,206,211],"FRTL-5":[110,177],"FRT":[112],"cells,":[114],"but":[115,169,293],"not":[116,170,269],"BRL":[118],"liver":[119],"The":[121],"strongest":[122],"by":[127,221],"-199":[129,156],"promoter,":[131],"rather":[137],"decreased":[138],"Co-expression":[140],"transcription":[143],"factor-1":[144],"(TTF-1)":[145],"increased":[146],"from":[153],"-3187":[154,214,237,255],"bp,":[157],"encompassed":[159],"one":[160],"or":[161,190],"two":[162],"TTF-1":[163],"binding":[164],"sites":[165],"identified,":[168],"-4206":[172,227,253],"promoter.":[174],"addition,":[176],"stable":[178],"transfectants":[179,195],"each":[180],"having":[181],"construct":[184],"cultured":[186],"presence":[189,208],"absence":[191,202],"TSH.":[193],"All":[194],"higher":[197,219],"TSH,":[210],"particular,":[212],"plasmid":[216],"significantly":[218],"comparison":[222],"-2617":[225,239],"constructs.":[229],"result":[231],"indicates":[232],"between":[236,252],"may":[241],"contribute":[242],"TSH/cAMP-induced":[244],"suppression":[245,262],"also":[247,294],"suggests":[248],"involves":[257],"element(s)":[259],"constitutive":[261],"results":[268],"only":[270],"suggest":[271],"possibly":[282],"contains":[283],"some":[284],"elements":[285],"regulation":[288],"expression,":[292],"emphasize":[295],"importance":[297],"minimal":[300],"efficient":[309],"expression":[310],"gene.":[313]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
