{"id":"https://openalex.org/W2028916286","doi":"https://doi.org/10.1523/jneurosci.2179-11.2011","title":"Behavioral Evidence for a Glucose Polymer Taste Receptor That Is Independent of the T1R2+3 Heterodimer in a Mouse Model","display_name":"Behavioral Evidence for a Glucose Polymer Taste Receptor That Is Independent of the T1R2+3 Heterodimer in a Mouse Model","publication_year":2011,"publication_date":"2011-09-21","ids":{"openalex":"https://openalex.org/W2028916286","doi":"https://doi.org/10.1523/jneurosci.2179-11.2011","mag":"2028916286","pmid":"https://pubmed.ncbi.nlm.nih.gov/21940444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3251913"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2179-11.2011","doi":"https://doi.org/10.1523/jneurosci.2179-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2179-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/38/13527.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/31/38/13527.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084351452","display_name":"Yada Treesukosol","orcid":"https://orcid.org/0000-0002-2640-6813","observed_orcids":["https://orcid.org/0000-0002-2640-6813"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yada Treesukosol","raw_affiliation_strings":["Department of Psychology, Florida State University, Tallahassee, Florida 32306-4301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Florida State University, Tallahassee, Florida 32306-4301, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043949307","display_name":"Kimberly Smith","orcid":"https://orcid.org/0000-0001-7414-9164","observed_orcids":["https://orcid.org/0000-0001-7414-9164"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly R. Smith","raw_affiliation_strings":["Department of Psychology and Program in Neuroscience, Florida State University, 1107 West Call Street, Tallahassee FL 32306-4301","Florida State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Program in Neuroscience, Florida State University, 1107 West Call Street, Tallahassee FL 32306-4301","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Florida State University","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091542363","display_name":"Alan C. Spector","orcid":"https://orcid.org/0000-0001-6817-6334","observed_orcids":["https://orcid.org/0000-0001-6817-6334"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan C. Spector","raw_affiliation_strings":["Department of Psychology and","Program in Neuroscience , Florida State University , Tallahassee , Florida 32306-4301","Florida State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and","institution_ids":[]},{"raw_affiliation_string":"Program in Neuroscience , Florida State University , Tallahassee , Florida 32306-4301","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Florida State University","institution_ids":["https://openalex.org/I103163165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I103163165"],"apc_list":null,"apc_paid":null,"fwci":5.1833,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.95305864,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"38","first_page":"13527","last_page":"13534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-polymers","display_name":"glucose polymers","score":0.7870000004768372},{"id":"https://openalex.org/keywords/taste-receptors","display_name":"taste receptors","score":0.7379999756813049},{"id":"https://openalex.org/keywords/t1r2","display_name":"T1R2","score":0.878000020980835},{"id":"https://openalex.org/keywords/t1r3","display_name":"T1R3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sweet-taste","display_name":"sweet taste","score":0.8199999928474426},{"id":"https://openalex.org/keywords/maltose","display_name":"maltose","score":0.628000020980835},{"id":"https://openalex.org/keywords/maltotriose","display_name":"maltotriose","score":1.0},{"id":"https://openalex.org/keywords/polycose","display_name":"Polycose","score":0.6890000104904175},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2780095022","wikidata":"https://www.wikidata.org/wiki/Q249208","display_name":"Maltotriose","level":4,"score":0.8203800916671753},{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.6765217781066895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6621896028518677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6276581287384033},{"id":"https://openalex.org/C2778197599","wikidata":"https://www.wikidata.org/wiki/Q170002","display_name":"Maltose","level":3,"score":0.6141470074653625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6098829507827759},{"id":"https://openalex.org/C178006227","wikidata":"https://www.wikidata.org/wiki/Q3454532","display_name":"Taste receptor","level":3,"score":0.585495114326477},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5673413872718811},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.5558004379272461},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3116205632686615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1912456452846527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16643062233924866},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.14860859513282776}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005936","descriptor_name":"Glucans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008320","descriptor_name":"Maltose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014312","descriptor_name":"Trisaccharides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.2179-11.2011","doi":"https://doi.org/10.1523/jneurosci.2179-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2179-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/38/13527.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:21940444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21940444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3251913","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3251913/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"mag:2189156461","doi":null,"is_oa":false,"landing_page_url":"https://www.jneurosci.org/content/31/38/13527.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2179-11.2011","doi":"https://doi.org/10.1523/jneurosci.2179-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2179-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/38/13527.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G825644333","display_name":"Psychophysical Evaluation of Taste Function","funder_award_id":"R01DC004574","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028916286.pdf","grobid_xml":"https://content.openalex.org/works/W2028916286.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W5603278","https://openalex.org/W1502937202","https://openalex.org/W1517221659","https://openalex.org/W1952062595","https://openalex.org/W1969201146","https://openalex.org/W1970250202","https://openalex.org/W1971425351","https://openalex.org/W1974490071","https://openalex.org/W1977343242","https://openalex.org/W1977860649","https://openalex.org/W1979241403","https://openalex.org/W1984918107","https://openalex.org/W1988836054","https://openalex.org/W1995303077","https://openalex.org/W1996564534","https://openalex.org/W1999103842","https://openalex.org/W1999403348","https://openalex.org/W2005668723","https://openalex.org/W2005683173","https://openalex.org/W2013707143","https://openalex.org/W2021279482","https://openalex.org/W2023939486","https://openalex.org/W2024471498","https://openalex.org/W2025072060","https://openalex.org/W2038573621","https://openalex.org/W2050321525","https://openalex.org/W2051613659","https://openalex.org/W2055015473","https://openalex.org/W2066479963","https://openalex.org/W2072827176","https://openalex.org/W2073115006","https://openalex.org/W2090663354","https://openalex.org/W2099666647","https://openalex.org/W2103465415","https://openalex.org/W2108542203","https://openalex.org/W2117836426","https://openalex.org/W2118268566","https://openalex.org/W2119368681","https://openalex.org/W2121596623","https://openalex.org/W2122060463","https://openalex.org/W2123799875","https://openalex.org/W2147945544","https://openalex.org/W2151677451","https://openalex.org/W2153000623","https://openalex.org/W2156645196","https://openalex.org/W2166037462","https://openalex.org/W2264657430","https://openalex.org/W4246772450","https://openalex.org/W4249590403","https://openalex.org/W4253646161"],"related_works":["https://openalex.org/W2166037462","https://openalex.org/W7112627910","https://openalex.org/W2561394447","https://openalex.org/W2136304815","https://openalex.org/W2156645196","https://openalex.org/W2740331959","https://openalex.org/W2089303539","https://openalex.org/W3025760709","https://openalex.org/W2080168588","https://openalex.org/W2172083490"],"abstract_inverted_index":{"Although":[0],"it":[1],"is":[2,23],"clear":[3],"that":[4,26,42,229],"the":[5,9,16,126,130,136,140,152,170,200,248],"heterodimer":[6],"formed":[7],"by":[8,34],"T1R2":[10,44,141,207],"and":[11,47,58,92,142,193],"T1R3":[12,48,143,209],"proteins":[13],"serves":[14],"as":[15,85],"primary":[17],"taste":[18,37,67,244],"receptor":[19,245],"for":[20,90,183],"sweeteners,":[21],"there":[22],"growing":[24],"evidence":[25,228],"responses":[27],"to":[28,55,76,99,117,135,167,216],"glucose":[29,122,221,230,240],"polymers":[30],"may":[31],"be":[32],"mediated":[33],"a":[35,65,86,119,218,243],"different":[36],"receptor.":[38,223],"Here":[39],"we":[40],"report":[41],"although":[43],"knock-out":[45],"(KO)":[46],"KO":[49,110,145,155,159],"mice":[50,111,146,204],"displayed":[51,112,163],"severely":[52],"impaired":[53],"responding":[54,166],"glucose,":[56,191],"maltose,":[57,192],"maltotriose":[59,93,194],"in":[60,125,133,151,169,196,202],"an":[61,233],"initial":[62],"session":[63],"of":[64,88,121,190,247],"brief-access":[66],"test":[68,172],"(5":[69],"s":[70],"trials,":[71],"25":[72],"min":[73],"sessions)":[74],"relative":[75],"wild-type":[77],"(WT)":[78],"mice,":[79,160,185],"they":[80],"subsequently":[81],"increased":[82],"their":[83],"licking":[84,116],"function":[87],"concentration":[89],"maltose":[91],"with":[94,104,139,213,232],"continued":[95],"testing,":[96],"presumably":[97],"due":[98],"associating":[100],"weak":[101],"oral":[102],"cues":[103],"positive":[105],"post-ingestive":[106],"consequences.":[107],"Interestingly,":[108],"these":[109],"relatively":[113],"normal":[114],"concentration-dependent":[115,165],"Polycose,":[118],"mixture":[120],"polymers,":[123,231],"even":[124],"first":[127,171],"session.":[128],"Importantly,":[129],"experience-dependent":[131],"increase":[132],"responsiveness":[134],"sugars":[137],"observed":[138],"single":[144],"was":[147],"not":[148],"statistically":[149],"significant":[150,164],"T1R2/3":[153],"double":[154,158],"mice.":[156],"The":[157],"however,":[161],"still":[162],"Polycose":[168,197],"session,":[173],"albeit":[174],"lick":[175],"rates":[176],"were":[177,198],"slightly":[178],"lower":[179],"than":[180,238],"those":[181],"seen":[182],"WT":[184,203],"perhaps":[186],"because":[187,206],"small":[188],"amounts":[189],"found":[195],"enhancing":[199],"signal":[201],"or":[205,208],"can":[210],"possibly":[211],"heteromerize":[212],"another":[214],"protein":[215],"form":[217],"fully":[219],"functional":[220],"polymer":[222],"These":[224],"findings":[225],"provide":[226],"behavioral":[227],"optimal":[234],"chain":[235],"length":[236],"greater":[237],"three":[239],"moieties,":[241],"stimulate":[242],"independent":[246],"T1R2+3":[249],"heterodimer.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}