{"id":"https://openalex.org/W2028890606","doi":"https://doi.org/10.1212/wnl.48.4.934","title":"Sex of parent transmission effect in Tourette's syndrome","display_name":"Sex of parent transmission effect in Tourette's syndrome","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2028890606","doi":"https://doi.org/10.1212/wnl.48.4.934","mag":"2028890606","pmid":"https://pubmed.ncbi.nlm.nih.gov/9109880"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.48.4.934","doi":"https://doi.org/10.1212/wnl.48.4.934","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.48.4.934","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088068647","display_name":"Valsamma Eapen","orcid":"https://orcid.org/0000-0001-6296-8306","observed_orcids":["https://orcid.org/0000-0001-6296-8306"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Valsamma Eapen","raw_affiliation_strings":["From the Academic Department of Psychiatry, University College London Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Academic Department of Psychiatry, University College London Medical School, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041313527","display_name":"Jane O\u2019Neill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane O'Neill","raw_affiliation_strings":["From the Academic Department of Psychiatry, University College London Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Academic Department of Psychiatry, University College London Medical School, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080773436","display_name":"Hugh Gurling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hugh M. D Gurling","raw_affiliation_strings":["From the Academic Department of Psychiatry, University College London Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Academic Department of Psychiatry, University College London Medical School, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108126082","display_name":"Mary May Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mary M. Robertson","raw_affiliation_strings":["From the Academic Department of Psychiatry, University College London Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Academic Department of Psychiatry, University College London Medical School, London, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":10.0144,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.98408131,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"48","issue":"4","first_page":"934","last_page":"936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.949999988079071},{"id":"https://openalex.org/keywords/parent-of-origin-effects","display_name":"parent-of-origin effects","score":0.8740000128746033},{"id":"https://openalex.org/keywords/matrilineal-inheritance","display_name":"matrilineal inheritance","score":0.7919999957084656},{"id":"https://openalex.org/keywords/patrilineal-inheritance","display_name":"patrilineal inheritance","score":0.996999979019165},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.9419999718666077},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/obsessive-compulsive-behavior","display_name":"obsessive-compulsive behavior","score":0.9549999833106995},{"id":"https://openalex.org/keywords/first-degree-relatives","display_name":"first-degree relatives","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8416386246681213},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.7944036722183228},{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.7265415787696838},{"id":"https://openalex.org/C69218264","wikidata":"https://www.wikidata.org/wiki/Q579704","display_name":"Non-Mendelian inheritance","level":4,"score":0.5297597050666809},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.4866696000099182},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4863319993019104},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.48536217212677},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47893911600112915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47574469447135925},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.45053809881210327},{"id":"https://openalex.org/C2909352501","wikidata":"https://www.wikidata.org/wiki/Q20998670","display_name":"Variable Expression","level":3,"score":0.4455799460411072},{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.4429362714290619},{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.4196358919143677},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35333821177482605},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25951725244522095},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25418031215667725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20497307181358337},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.20001420378684998},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12626659870147705},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11793377995491028},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11792409420013428},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.10293638706207275},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005220","descriptor_name":"Fathers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018392","descriptor_name":"Genomic Imprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1212/wnl.48.4.934","doi":"https://doi.org/10.1212/wnl.48.4.934","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.48.4.934","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:9109880","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9109880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:89031","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/89031/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology , 48 (4) pp. 934-937. (1997)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047276367","https://openalex.org/W1979222528","https://openalex.org/W7133560828","https://openalex.org/W7037922037","https://openalex.org/W1965689992","https://openalex.org/W2022801832","https://openalex.org/W2522176543","https://openalex.org/W6939458393","https://openalex.org/W2142185958","https://openalex.org/W2090210495"],"abstract_inverted_index":{"Parent":[0],"of":[1,13,16,55,67,73,97,104,112,144,176,202],"origin":[2,145],"effects":[3],"caused":[4],"by":[5,91,156],"genomic":[6],"imprinting":[7],"may":[8,166],"influence":[9],"the":[10,53,65,71,77,98,105,122,128,148,169,174,199],"phenotypic":[11,48,100],"expression":[12],"a":[14,133,142,183],"number":[15],"heritable":[17],"human":[18],"disorders.":[19],"To":[20],"test":[21],"this":[22],"phenomenon":[23],"in":[24,52,64,121,179],"Tourette's":[25],"syndrome":[26],"(TS),":[27],"we":[28],"studied":[29],"437":[30,78],"first":[31],"degree":[32],"relatives":[33],"systematically":[34],"ascertained":[35],"through":[36],"57":[37],"probands.":[38],"We":[39,116],"compared":[40],"age":[41,44,123,136],"at":[42,45,124,137],"onset,":[43],"diagnosis,":[46],"and":[47,60,84,102,181,192],"expressions":[49,101],"as":[50,89],"observed":[51],"diagnosis":[54,125],"TS,":[56,180],"chronic":[57],"motor":[58],"tics,":[59],"obsessive":[61],"compulsive":[62],"behavior":[63],"offspring":[66,72,131],"affected":[68,74],"males":[69],"with":[70],"females.":[75],"Of":[76],"subjects,":[79],"16.7%":[80],"had":[81,86],"matrilineal":[82],"inheritance":[83],"13.9%":[85],"patrilineal":[87],"inheritance,":[88],"determined":[90],"family":[92,187],"history":[93],"methodology.":[94],"Chi-square":[95],"analysis":[96],"different":[99],"sex":[103],"transmitting":[106],"parent":[107,143],"failed":[108],"to":[109,141,185],"provide":[110],"evidence":[111],"significant":[113,119],"group":[114],"differences.":[115],"found":[117],"no":[118],"differences":[120],"either.":[126],"However,":[127],"maternally":[129,191],"transmitted":[130,194],"showed":[132],"significantly":[134],"earlier":[135],"onset.":[138],"This":[139],"points":[140],"effect":[146],"on":[147],"putative":[149],"TS":[150],"gene":[151],"that":[152],"could":[153],"be":[154],"explained":[155],"meiotic":[157],"events":[158],"or":[159],"even":[160],"intrauterine":[161],"environmental":[162],"influences.":[163],"These":[164],"findings":[165],"help":[167],"explain":[168],"hitherto":[170],"conflicting":[171],"reports":[172],"about":[173],"nature":[175],"genetic":[177],"transmission":[178],"suggest":[182],"need":[184],"re-examine":[186],"data":[188],"separately":[189],"for":[190],"paternally":[193],"cases,":[195],"taking":[196],"into":[197],"account":[198],"possible":[200],"role":[201],"imprinting.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
