{"id":"https://openalex.org/W2028838248","doi":"https://doi.org/10.1194/jlr.d300037-jlr200","title":"Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay","display_name":"Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W2028838248","doi":"https://doi.org/10.1194/jlr.d300037-jlr200","mag":"2028838248","pmid":"https://pubmed.ncbi.nlm.nih.gov/14617738"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.d300037-jlr200","doi":"https://doi.org/10.1194/jlr.d300037-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.d300037-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520319106/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jlr.org/article/S0022227520319106/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015516537","display_name":"Aaron T. Lada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron T. Lada","raw_affiliation_strings":["Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Davis","raw_affiliation_strings":["Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032697738","display_name":"Carol R. Kent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Kent","raw_affiliation_strings":["Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Chapman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Chapman","raw_affiliation_strings":["College of Pharmacy, University of South Carolina, Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of South Carolina, Columbia, SC","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007441298","display_name":"Hiroshi Tomoda","orcid":"https://orcid.org/0000-0002-1241-8901","observed_orcids":["https://orcid.org/0000-0002-1241-8901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Tomoda","raw_affiliation_strings":["The Kitasato Institute, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Kitasato Institute, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045164227","display_name":"Satoshi \u014cmura","orcid":"https://orcid.org/0000-0002-9187-2044","observed_orcids":["https://orcid.org/0000-0002-9187-2044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Omura","raw_affiliation_strings":["The Kitasato Institute, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Kitasato Institute, Tokyo, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108472089","display_name":"Lawrence L. Rudel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence L. Rudel","raw_affiliation_strings":["Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108472089"],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.2928,"has_fulltext":true,"cited_by_count":134,"citation_normalized_percentile":{"value":0.87904968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"45","issue":"2","first_page":"378","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acat1","display_name":"ACAT1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/acat2","display_name":"ACAT2","score":1.0},{"id":"https://openalex.org/keywords/acyl-coa-cholesterol-acyltransferase","display_name":"acyl-CoA:cholesterol acyltransferase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cholesteryl-ester-synthesis","display_name":"cholesteryl ester synthesis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7049999833106995},{"id":"https://openalex.org/keywords/enterocytes","display_name":"enterocytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lipoprotein-cholesterol","display_name":"lipoprotein cholesterol","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.8727108240127563},{"id":"https://openalex.org/C2776448209","wikidata":"https://www.wikidata.org/wiki/Q415555","display_name":"Cholesteryl ester","level":4,"score":0.6068311333656311},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5949456691741943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.585317850112915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5468652844429016},{"id":"https://openalex.org/C2779685201","wikidata":"https://www.wikidata.org/wiki/Q2699537","display_name":"Acyl-CoA","level":3,"score":0.5266851186752319},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.4492444396018982},{"id":"https://openalex.org/C2775970874","wikidata":"https://www.wikidata.org/wiki/Q2609152","display_name":"Acyltransferase","level":3,"score":0.44703003764152527},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4161701798439026},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3421916961669922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31478753685951233},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2967628836631775}],"mesh":[{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009327","descriptor_name":"4-Chloro-7-nitrobenzofurazan","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009327","descriptor_name":"4-Chloro-7-nitrobenzofurazan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1194/jlr.d300037-jlr200","doi":"https://doi.org/10.1194/jlr.d300037-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.d300037-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520319106/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:14617738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14617738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:582755e203b848e19251f0313653c6ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/582755e203b848e19251f0313653c6ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 45, Iss 2, Pp 378-386 (2004)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.d300037-jlr200","doi":"https://doi.org/10.1194/jlr.d300037-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.d300037-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520319106/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2927051671","display_name":"NUTRITION AND LIPOPROTEIN METABOLISM IN ATHEROSCLEROSIS","funder_award_id":"R01HL024736","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8993664908","display_name":"Lipoprotein Metabolism in Atherosclerosis","funder_award_id":"P01HL049373","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028838248.pdf","grobid_xml":"https://content.openalex.org/works/W2028838248.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1490548175","https://openalex.org/W1508733793","https://openalex.org/W1775749144","https://openalex.org/W1832765217","https://openalex.org/W1967018843","https://openalex.org/W1967630525","https://openalex.org/W1972519777","https://openalex.org/W1983130452","https://openalex.org/W1990662818","https://openalex.org/W1991594636","https://openalex.org/W2001718927","https://openalex.org/W2017145860","https://openalex.org/W2022923134","https://openalex.org/W2035187068","https://openalex.org/W2068345120","https://openalex.org/W2090346215","https://openalex.org/W2106508078","https://openalex.org/W2115904158","https://openalex.org/W2133097088","https://openalex.org/W2151750517","https://openalex.org/W2158964347","https://openalex.org/W2167670101","https://openalex.org/W2184912837","https://openalex.org/W2401004764","https://openalex.org/W2513050187"],"related_works":["https://openalex.org/W2169792817","https://openalex.org/W1968301126","https://openalex.org/W1832765217","https://openalex.org/W2006831721","https://openalex.org/W3201656624","https://openalex.org/W2090346215","https://openalex.org/W2158964347","https://openalex.org/W7095567904","https://openalex.org/W1979830788","https://openalex.org/W2020585666"],"abstract_inverted_index":{"Acyl":[0],"CoA:cholesterol":[1],"acyltransferase":[2],"1":[3],"(ACAT1)":[4],"and":[5,21,28,43,61,115,138,154,162,177],"ACAT2":[6,22,44,95,155,172,190],"are":[7,23,38],"enzymes":[8],"responsible":[9],"for":[10,56,158],"the":[11,26,30,79,84,100,105,169,179,198],"formation":[12],"of":[13,59,64,108,122,149,152,164,189,200],"cholesteryl":[14],"esters":[15],"in":[16,25,83,160,197],"tissues.":[17],"While":[18],"both":[19],"ACAT1":[20,42,60,93,135,153],"present":[24],"liver":[27],"intestine,":[29],"cells":[31,88],"containing":[32],"either":[33,92],"enzyme":[34],"within":[35],"these":[36,165],"tissues":[37],"distinct,":[39],"suggesting":[40],"that":[41,143,171,184],"have":[45,130],"separate":[46],"functions.":[47],"In":[48],"this":[49],"study,":[50],"NBD-cholesterol":[51,74],"was":[52,81,112,116,141],"used":[53],"to":[54,104,129,175,193],"screen":[55],"specific":[57],"inhibitors":[58],"ACAT2.":[62,146],"Incubation":[63],"AC29":[65,87],"cells,":[66],"which":[67],"do":[68],"not":[69],"contain":[70],"ACAT":[71,123],"activity,":[72],"with":[73,91,98,118],"showed":[75],"weak":[76],"fluorescence":[77],"when":[78],"compound":[80,140],"localized":[82,103],"membrane.":[85],"When":[86],"stably":[89],"transfected":[90],"or":[94],"were":[96,127],"incubated":[97],"NBD-cholesterol,":[99],"fluorescent":[101,114],"signal":[102],"nonpolar":[106],"core":[107],"cytoplasmic":[109],"lipid":[110],"droplets":[111],"strongly":[113],"correlated":[117],"two":[119,166,181],"independent":[120],"measures":[121],"activity.":[124],"Several":[125],"compounds":[126],"found":[128],"greater":[131],"inhibitory":[132],"activity":[133],"toward":[134],"than":[136],"ACAT2,":[137],"one":[139],"identified":[142],"specifically":[144],"inhibits":[145],"The":[147],"demonstration":[148],"selective":[150,187],"inhibition":[151,188],"provides":[156],"evidence":[157],"uniqueness":[159],"structure":[161],"function":[163],"enzymes.":[167],"To":[168],"extent":[170],"is":[173],"confined":[174],"hepatocytes":[176],"enterocytes,":[178],"only":[180],"cell":[182],"types":[183],"secrete":[185],"lipoproteins,":[186],"may":[191],"prove":[192],"be":[194],"most":[195],"beneficial":[196],"reduction":[199],"plasma":[201],"lipoprotein":[202],"cholesterol":[203],"concentrations.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
