{"id":"https://openalex.org/W2028828868","doi":"https://doi.org/10.1093/annhyg/32.inhaled_particles_vi.1017","title":"The Induction of Nuclear Abnormalities in the Alveolar Macrophages of Mouse Lung After Inhalation of 239PuO2","display_name":"The Induction of Nuclear Abnormalities in the Alveolar Macrophages of Mouse Lung After Inhalation of 239PuO2","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2028828868","doi":"https://doi.org/10.1093/annhyg/32.inhaled_particles_vi.1017","mag":"2028828868"},"language":"en","primary_location":{"id":"doi:10.1093/annhyg/32.inhaled_particles_vi.1017","doi":"https://doi.org/10.1093/annhyg/32.inhaled_particles_vi.1017","is_oa":false,"landing_page_url":"https://doi.org/10.1093/annhyg/32.inhaled_particles_vi.1017","pdf_url":null,"source":{"id":"https://openalex.org/S206992039","display_name":"The Annals of Occupational Hygiene","issn_l":"0003-4878","issn":["0003-4878","1475-3162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Occupational Hygiene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043528095","display_name":"S. R. Moores","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092957","display_name":"Research Complex at Harwell","ror":"https://ror.org/00gqx0331","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210092957"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. R. Moores","raw_affiliation_strings":["Inhalation Toxicology Group, B. 551, AERE Harwell, Oxon., UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalation Toxicology Group, B. 551, AERE Harwell, Oxon., UK","institution_ids":["https://openalex.org/I4210092957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113631880","display_name":"R. J. E. Talbot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092957","display_name":"Research Complex at Harwell","ror":"https://ror.org/00gqx0331","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210092957"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. J. Talbot","raw_affiliation_strings":["Inhalation Toxicology Group, B. 551, AERE Harwell, Oxon., UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalation Toxicology Group, B. 551, AERE Harwell, Oxon., UK","institution_ids":["https://openalex.org/I4210092957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111618370","display_name":"Lynn G. Nicholls","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092957","display_name":"Research Complex at Harwell","ror":"https://ror.org/00gqx0331","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210092957"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Nicholls","raw_affiliation_strings":["Inhalation Toxicology Group, B. 551, AERE Harwell, Oxon., UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalation Toxicology Group, B. 551, AERE Harwell, Oxon., UK","institution_ids":["https://openalex.org/I4210092957"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101414705","display_name":"Amy Elizabeth Morgan","orcid":"https://orcid.org/0000-0001-7557-6651","observed_orcids":["https://orcid.org/0000-0001-7557-6651"]},"institutions":[{"id":"https://openalex.org/I4210092957","display_name":"Research Complex at Harwell","ror":"https://ror.org/00gqx0331","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210092957"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Morgan","raw_affiliation_strings":["Inhalation Toxicology Group, B. 551, AERE Harwell, Oxon., UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalation Toxicology Group, B. 551, AERE Harwell, Oxon., UK","institution_ids":["https://openalex.org/I4210092957"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210092957"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.21756849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10946","display_name":"Radioactivity and Radon Measurements","score":0.5175999999046326,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10946","display_name":"Radioactivity and Radon Measurements","score":0.5175999999046326,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.4424000084400177,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plutonium-dioxide","display_name":"plutonium dioxide","score":0.8399999737739563},{"id":"https://openalex.org/keywords/inhaled-plutonium","display_name":"inhaled plutonium","score":0.5699999928474426},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9549999833106995},{"id":"https://openalex.org/keywords/radiation-induced-chromosome-damage","display_name":"radiation-induced chromosome damage","score":0.5559999942779541},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.40799999237060547},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.47699999809265137},{"id":"https://openalex.org/keywords/cba-h-mice","display_name":"CBA/H mice","score":0.6669999957084656},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.7888259887695312},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6545948386192322},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.517164409160614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4665246903896332},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33862027525901794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2610394060611725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18465480208396912},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1297050416469574}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/annhyg/32.inhaled_particles_vi.1017","doi":"https://doi.org/10.1093/annhyg/32.inhaled_particles_vi.1017","is_oa":false,"landing_page_url":"https://doi.org/10.1093/annhyg/32.inhaled_particles_vi.1017","pdf_url":null,"source":{"id":"https://openalex.org/S206992039","display_name":"The Annals of Occupational Hygiene","issn_l":"0003-4878","issn":["0003-4878","1475-3162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Occupational Hygiene","raw_type":"journal-article"},{"id":"pmh:oai:open-archive.highwire.org:annhyg:32/inhaled_particles_VI/1017","doi":null,"is_oa":false,"landing_page_url":"http://annhyg.oxfordjournals.org/cgi/content/short/32/inhaled_particles_VI/1017","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W126450993","https://openalex.org/W1971777877","https://openalex.org/W2000729969","https://openalex.org/W2027831677","https://openalex.org/W2044988032","https://openalex.org/W2062096952","https://openalex.org/W2081723025","https://openalex.org/W4300652411"],"related_works":["https://openalex.org/W2159467637","https://openalex.org/W1999725191","https://openalex.org/W2087426716","https://openalex.org/W155045550","https://openalex.org/W7101122148","https://openalex.org/W2060429941","https://openalex.org/W2033192837","https://openalex.org/W289499361","https://openalex.org/W2016024575","https://openalex.org/W2172323760"],"abstract_inverted_index":{"Effects":[0],"of":[1,8,11,25,32,46,54,83,106,112,119],"inhaled":[2],"239PuO2":[3,113],"on":[4],"the":[5,9,52,55,58,63,102,150],"free-cell":[6],"population":[7],"lungs":[10],"CBA/H":[12],"mice":[13],"have":[14],"been":[15],"studied":[16],"using":[17,39],"broncho-alveolar":[18],"lavage":[19],"following":[20,91],"initial":[21],"alveolar":[22,34],"depositions":[23],"(IADs)":[24],"209":[26],"to":[27,61,71,122,128],"2800":[28],"Bq.":[29],"The":[30,44,81,132],"numbers":[31],"pulmonary":[33],"macrophages":[35],"(PAM)":[36],"were":[37,65,101],"quantified":[38],"a":[40,96,110,116],"radioactive":[41],"tracer":[42],"technique.":[43],"number":[45,82],"PAM":[47,85,100],"declined":[48],"soon":[49],"after":[50,78],"exposure;":[51],"extent":[53],"depression":[56],"and":[57,86],"time":[59],"taken":[60],"reach":[62],"nadir":[64],"both":[66],"dose-dependent.":[67],"Numbers":[68],"eventually":[69],"returned":[70],"normal":[72],"but,":[73],"with":[74,88],"high":[75],"IADs,":[76],"only":[77],"3":[79],"months.":[80],"binucleate":[84],"those":[87],"micronuclei":[89],"increased":[90],"relatively":[92],"low":[93],"IADs":[94],"in":[95,140,143],"dose-dependent":[97],"manner.":[98],"Micronucleate":[99],"most":[103],"sensitive":[104],"indicator":[105],"cellular":[107],"damage":[108,121],"as":[109],"result":[111],"inhalation,":[114],"providing":[115],"short-term":[117],"assessment":[118],"radiation":[120],"lung":[123,130],"cells":[124],"at":[125],"doses":[126],"known":[127],"produce":[129],"tumours.":[131],"results":[133],"also":[134],"provide":[135],"further":[136],"evidence":[137],"that":[138],"mitosis":[139],"PAM,":[141],"or":[142],"their":[144],"precursor":[145],"cells,":[146],"does":[147],"occur":[148],"within":[149],"lung.":[151]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}